Nucleotide fragments capable of hybridizing specifically to rickettsia rDNA or rRNA and their use as probes or primers

ABSTRACT

The invention relates to oligonucleotide primers and probes that can specifically hybridize to the rDNA or rRNA of at least one species of the genus Rickettsia.

The present invention falls within the field of techniques for thedetection and/or identification of bacteria of the genus Rickettsia andmore particularly of those using a genetic marker.

Rickettsias are Gram-negative bacteria which belong to the orderRickettsiales and to the family Rickettsiaceae comprising especially thesubfamily Rickettsieae which is subdivided into three genera: Coxiella,of which the only known species is Coxiella burnetti; Rickettsia,including all the other species which are pathogenic to man and animals;and Rochalimea. The genus Rickettsia comprises three subgroups: thetyphus group to which R. typhi, responsible for endemic typhus, R.prowazekii, responsible for epidemic typhus, and R. canada belong; thescrub typhus group to which R. tsutsugamushi belongs; and the eruptivefever group to which R. rickettsii, R. siberica, R. conorii, R.australis, R. akari, R. montana and R. rhipicephali in particularbelong.

Rickettsias are intracellular parasitic bacteria which multiply in thenucleus and the cytoplasm of the host cells for the strains of theeruptive fever group and in the cytoplasm of these cells for the strainsof the other groups. The transmission of the bacteria to man occursthrough haematophagous insects such as ticks for R. tsutsugamushi(rickettsia of the eruptive fever group), lice for R. prowazekii or fleafor R. typhi, during a blood meal followed by dejecta at the site of thebite.

Epidemic typhus due to R. prowazekii characterized by high fever, severeheadaches and generalized rashes has nowadays become a rare disease.However, the risk still exists of an outbreak of an epidemic as long asthe required conditions are brought together, in particular when thepopulation is dense and hygienic conditions are lacking.

Scrub typhus or endemic typhus, caused by R. typhi, is widespreadworldwide. Rats are the carriers and their presence determines theappearance of the disease in man. The infection is characterized byheadaches, myalgia and fever but, most often, the disease is benign.

Some of the infections associated with rickettsias of the eruptive fevergroup, and especially the Rocky Mountains spotted fever caused by R.rickettsii, can have a fatal outcome for the patient or can at the veryleast be accompanied by severe complications such as myocarditis,phlebitis, syndrome of meningeal irritation, encephalitis, myelitis andcoma.

Scrub typhus is an acute febrile disease the causative agent of which isR. tsutsugamushi. The disease is characterized by a rise in temperatureand severe headaches, which may be associated with a pneumopathy duringthe first week of the disease. Moreover, the disease may affect thecentral nervous system, with clinical manifestations such as delirium,stupor and muscle fibrillation. The death rate varies from 1 to 60%depending on the geographical regions. It is particularly high inSouth-East Asia, Korea, Australia, Japan and India.

At the present time, no detection technique is, at the same time,specific, sensitive and rapid enough to diagnose an infection due tobacteria of the genus Rickettsia in a biological sample. Testing for theinfection is carried out essentially either by direct diagnosis, whichis very awkward to carry out because it presupposes the inoculation,using biological samples, of embyronated eggs or animals; or byserological diagnosis, which is often difficult because of the lack ofspecificity of the techniques used or because of the delayed appearanceof antibodies in the sera of patients.

The present invention relates to a technique for the diagnosis ofinfections caused by bacteria of the genus Rickettsia, and moreparticularly those caused by R. tsutsugamushi, using a genetic marker ina process of detection by hybridization of nucleic acids, combiningspecificity, sensitivity and speed.

More particularly, the ribosomal RNA of the bacteria is used as target.Indeed, this molecule is found in abundance in all the cells of allliving organisms. Moreover, it has a specific nucleotide sequence madeup of a succession of regions characterized by a variable rate ofevolution.

Bacterial ribosomes contain at least three distinct RNA moleculesreferenced 5S, 16S and 23S rRNA(s). Historically, these names werechosen with reference to their speed of sedimentation which reflects thesize of these RNA molecules. However, the real size of these ribosomalconstituents varies substantially, for a given type, from one cellularorganism to another. However, the terminology 5S, 16S and 23S rRNA isconfined to describing the RNA molecules which constitute the ribosomesin all bacteria.

The taxonomic value of the ribosomal 16S and 23S subunits of variousbacterial species has been demonstrated in hybridization processes forquantifying levels of homology between these species. Thus, Woese etal., Microbiological Reviews 47: 621-669 (1983) and Grayet et al.,Nucleic Acids Research 12: 5837-5852 (1984) show, by comparisons of 16SRNA sequences, that highly conserved regions are intercalated withregions of average and low homology, even in the case of close species.

To date, only six DNA sequences corresponding to the 16S ribosomal RNAs(rDNA) of bacteria belonging to the Rickettsiaceae family are describedin the literature: R. rickettsii, R. prowezekii, R. typhi, Coxiellaburnetti, Ehrlichia ristierii and Wolbachia persicae.

Somes zones of the DNA encoding the 16S subunit ribosomal RNA have nowbeen discovered which are conserved for various species belonging to thegenus Rickettsia. Moreover, there have now been discovered on the DNAencoding the 16S ribosomal RNA zones which are variable within the genusRickettsia. These results have made it possible to prepare probes of thetype which make it possible to discriminate between the genus Rickettsiaand genera which are taxonomically close, as well as probes specific forspecies belonging to the genus Rickettsia. These results have beenverified especially on the following species: R. tsutsugamushi, R.canada, R. conorii, R. akari, R. mooseri, R. australis, R. rhipicephali,R. montana, R. bellii, R. japonica, R. parkeri, R. helvetica, R.sibirica, R. massiliae, R. slovaca and R. africae.

Before presenting the invention, various terms used in the descriptionand the claims are defined below:

a nucleotide fragment or an oligonucleotide is a chain of nucleotideunits assembled together by phosphoric ester bonds, which ischaracterized by the informational sequence of the natural nucleicacids, capable of hybridizing to a nucleotide fragment underpredetermined conditions, it being possible for the chain to containmonomers of differing structures and to be obtained from a naturalnucleic acid molecule and/or by genetic recombination and/or by chemicalsynthesis,

a unit is derived from a monomer which may be a natural nucleotide of anucleic acid whose constituent elements are a sugar, a phosphate groupand a nitrogenous base; in DNA, the sugar is 2-deoxyribose; in RNA, thesugar is ribose; depending on whether DNA or RNA is involved, thenitrogenous base is chosen from adenine, guanine, uracil, cytosine,thymine; or alternatively the monomer is a nucleotide modified in atleast one of the three constituent components; by way of example, themodification may occur either at the level of the bases, with modifiedbases such as inosine, 5-methyldeoxycytidine, deoxyuridine,5-dimethylaminodeoxyuridine, 2,6-diaminopurine, 5-bromodeoxyuridine orany other modified base capable of hybridization, or at the level of thesugar, for example the replacement of at least one deoxyribose with apolyamide (P. E. Nielsen et al., Science, 254, 1497-1500 (1991)), oralternatively at the level of the phosphate group, for example itsreplacement by esters especially chosen from diphosphates, alkyl andaryl phosphonates and phosphorothioates,

"informational sequence" is understood to mean any orderly succession ofnucleotide type units, the chemical nature and the order in a referencedirection of which constitute information of the same quality as that ofthe natural nucleic acids,

hybridization is understood to mean the process during which, underappropriate conditions, two nucleotide fragments, having sufficientlycomplementary sequences, are capable of forming a double strand withstable and specific hydrogen bonds. A nucleotide fragment "capable ofhybridizing" with a polynucleotide is a fragment which can hybridizewith the said polynucleotide under hybridization conditions, which canbe determined in each case in a known manner. The hybridizationconditions are determined by the stringency, that is to say theharshness of the operating conditions. The higher the stringency, themore specific the hybridization. The stringency is defined especiallyaccording to the base composition of a probe/target duplex, as well asby the degree of mismatch between two nucleic acids. The stringency mayalso depend on the reaction parameters, such as the concentration andthe type of ionic species present in the hybridization solution, thenature and the concentration of the denaturing agents and/or thehybridization temperature. The stringency of the conditions under whicha hybridization reaction should be carried out will depend mainly on theprobes used. All these parameters are well known and the appropriateconditions can be determined by persons skilled in the art. In general,depending on the length of the probes used, the temperature for thehybridization reaction is between about 20 and 65° C., in particularbetween 35 and 65° C. in a saline solution at a concentration of about0.8 to 1M,

a probe is a nucleotide fragment comprising from 5 to 100 monomers,especially from 6 to 35 monomers, having a hybridization specificityunder determined conditions for forming a hybridization complex with anucleotide fragment having, in the present case, a nucleotide sequenceincluded in a ribosomal RNA, the DNA obtained by reverse transcriptionof the said ribosomal RNA and the DNA (called here ribosomal DNA orrDNA) of which the said ribosomal RNA is the product of transcription; aprobe may be used for diagnostic purposes (especially capture ordetection probes) or for therapeutic purposes,

a capture probe is immobilized or is capable of being immobilized on asolid support by any appropriate means, that is to say directly orindirectly, for example by covalent bonding or adsorption,

a detection probe may be labelled by means of a marker chosen fromradioactive isotopes, enzymes (especially a peroxidase, an alkalinephosphatase, or an enzyme capable of hydrolysing a chromogenic,fluorigenic or luminescent substrate), chromophoric chemical compounds,chromogenic, fluorigenic or luminescent compounds, nucleotide baseanalogues, and ligands such as biotin,

a primer is a probe comprising from 5 to 100 nucleotide units and havinga hybridization specificity under determined conditions for theinitiation of an enzymatic polymerization, for example in anamplification technique such as PCR (Polymerase Chain Reaction), in asequencing process, in a reverse transcription method, and the like,

homology characterizes the degree of similarity between two nucleotidefragments which are compared,

the probes and primers according to the invention are those whosesequences are identified below, as well as the analogues of these probesor primers which are those whose sequences exhibit at least 70%homology, and at least 5 consecutive nucleotide units of informationalsequence identical therewith. Such sequences are called here "homologoussequences".

The probes according to the invention which are used for diagnosticpurposes can be used in any known hybridization technique and especiallythe techniques for point deposition on filters called "DOT BLOTTING"(MANIATIS et al., Molecular Cloning, Cold Spring Harbor, 1982), thetechniques for DNA transfer called "SOUTHERN BLOTTING" (SOUTHERN. E. M.,J. Mol. Biol., 98, 503 (1975), the techniques for RNA transfer called"NORTHERN BLOTTING", or the SANDWICH techniques (DUNN A. R., HASSEL J.A., Cell, 12, 23 (1977)); the SANDWICH technique is used in particular,with a specific capture probe and/or a specific detection probe, itbeing understood that the capture probe and the detection probe shouldhave at least partly different nucleotide sequences.

Another application of the invention is a therapy probe for treatinginfections caused by bacteria of the genus Rickettsia, the said probebeing capable of hybridizing in vivo with the 16S ribosomal RNA of thesaid bacteria and/or with the genomic DNA to block the translationand/or transcription phenomena and/or replication.

Table 1 represents the rDNA sequences corresponding to the 16S rRNA ofvarious bacteria of the genus Rickettsia, the list of which appearsafter the experimental part below. The numbering of the nucleotidesequence of the DNA corresponding to the 16S ribosomal RNA of R.rickettsii, completely identified by Weisburg et al. (1989, Genbank(M21293)), was used as reference to define the fragments and to alignthem. The nucleotide sequences corresponding to the sequences shown inTable 1 appear as SEQ ID NOS: 23-53.

The subject of the present invention is especially a single-strandednucleotide fragment capable of hybridizing with Rickettsia rDNA or rRNAand not with non-Rickettsia rDNA or rRNA.

In particular, the single-stranded nucleotide fragment is not capable ofhybridizing specifically to the rDNA or rRNA of Cowdria ruminantium,Ehrlichia chaffeensis, Anaplasma marginale, Wolbachia pipientis,Ehrlichia risticii, Rochalimea quintana and Coxiella burnatti.

                                      TABLE 1                                     __________________________________________________________________________              10        20        30        40        50        60                  1                                                                             14                                                                            10                                                                            11                                                                            3                                                                             18                                                                            13                                                                            7                                                                             15                                                                            16                                                                            8                                                                             17                                                                            6                                                                             9                                                                             12                                                                            4                                                                             5                                                                             31                                                                            2                                                                             21                                                                            22                                                                            19                                                                           GA--------CAGAA---------------7                                                20                                                                           xx--------CA------------------2                                                23                                                                            26TTTACGTTTCTTATATTTGTTTTTTTGCATGAGTCCAAGCCATAAGTAATTATGGTTTTG60                                                       25                                   27                                                                            28                                                                            24CT----------------------------------------------------------2                                                        30                                   29                                                                           x-----------0                                                                  C                                                                              -        70        80        90       100       110       120                1                                                                            CCTGGCTCAGAACGAACGCTATCGGTATGCTTAACACATGC41                                    14                                                                           xx.......................................39                                    10                                                                           xxxxxxxx.................................33                                    11                                                                           .........................................41                                    3                                                                            xxxxxxxxxxxxx............................28                                    18                                                                           .........................................41                                    13                                                                           .........................................41                                    7                                                                            .........................................41                                    15                                                                           xx.......................................39                                    16                                                                           xxxxxxxxxxx..............................30                                    8                                                                            .........................................41                                    17                                                                           xxxx.....................................37                                    6                                                                            .........................................41                                    9                                                                            .........................................41                                    12                                                                           .............A...........................41                                    4                                                                            .........................................41                                    5                                                                            .........................................41                                    31                                                                           .........................25                                                    2                                                                            .........................................41                                    21                                                                           AGAGTTTGAT.........................................51                          22                                                                           .........................................41                                    19TCAAACTTGAGAGTTTGAT.........................................67                                                       20                                  AACTTGAGAGTTTGAT.........................................59                    23                                                                           ..................GG...C....C..........39                                      26TCAAACTTGAGAGTTTGAT....................GG...C.A.............120                                                      25                                  ...............GG...C.A..C..........36                                         27                                                                           AGAGTTTGAT....................GG...C.A.............51                          28                                                                           .......T.......GG...C.G..C..........37                                         24                                                                           GATTTGAGAGTTTGAT.....................G.....G.............59                    30                                                                           ...............GG...C.G.............36                                         29                                                                           xATTGAAGAGTTTGATT..........TT........G...C...............56                    C                                                                            ++++************CCCT*+CGG+A*GC*TAACACATGC                                       -       130       140       150       160       170       180                1AAGTCGAACGGACTAATT---GGGGCTT----GCTCCAA--TT-AGTTAGTGGCAGACGG91                                                        14..................---.......-                                              ---.......--..-................8                                              9                                     10..................---.......----.......--..-................83                                                       11..................---.......-                                              ---.......--..-................9                                              1                                     3..................---.......----......G--..-................78                                                        18..................---.......-                                              ---......G--..-................9                                              1                                     13..................---.......----......G--..-................91                                                       7..................T--.......--                                              --.......--..T................93      15..................T--.......----.......--..-................90                                                       16..........A.......TTT.......-                                              ---.......--..-................8                                              3                                     8..................---.......----....T..--..-................91                                                        17..................---.......-                                              ---.......--..-................8                                              7                                     6...........G......---.......----.......--..-................91                                                        9..................---..A....--                                              --.......--..-................91      12..................---.......----.T....G--..-................91                                                       4......G...........G--....T..--                                              --A...T..--..-................92      5......G.......G..---T....T..----T.....G--..-...G......GA....91                                                        31......G...........---.......-                                              ---.......--..-................7                                              5                                     2..................G--...-...----.......--..-................91                                                        21.....A............---.......-                                              ---.......--..-................1                                              01                                    22.................---TA......----....T..--..-................91                                                       19............T...C---TA.A...C-                                              ---...TT.G--..-.A.........A....1                                              17                                    20............T....---TA.A....----....T.G--..-.A..............109                                                      23..........A.T....GCT--.A.T..-                                              ---...TAGT--A.T.A.........A....9                                              1                                     26.............AGT.ATTTATA..--TTCG...ATG.GTA.CT...............178                                                      25.............A.T.GCTTATAA.C.T                                              TCG.T.AT..ATAATT...............9                                              6                                     27......... ...CGTA-TAC.CA....----...G.GT-G.ATG...............105                                                      28............G.T..A-TT.TA....-                                              ---...ATGG-TA.A.C..............9                                              1                                     24............A------TCA.....----GCT.G..GCC..GGTCCC...........109                                                      30.......G..C...-----------...T                                              TAG------------...G..C....A....7                                              3                                     29...........--C.GCGCAG..A.xC.T---x....TGGCGGCG-AG......G.....108                                                      CAAGTC***CG*******+  .+*+****                                                  ***++*:  ** *****G*GGC**ACGG                                                  -        190       200                                                      210       220       230                                                       240                                   1GTGAGTAACACGTGGGAATCTACCCATCAGTACGGAATAACTTTTAGAAATAAAAGCTAA151                                                       14.............................                                              ...............................1                                              49                                    10............................................................143                                                      11.............................                                              ...............................1                                              51                                    3...........................T................................138                                                       18...........................T.                                              ...............................1                                              51                                    13...........................T................................151                                                      7...........................T..                                              ..............................15                                              3                                     15...........................T................................150                                                      16...........................T.                                              ...............................1                                              43                                    8............................................................151                                                       17.............................                                              ...............................1                                              47                                    6............................................................151                                                       9.........G....................                                              ..............................15                                              1                                     12................................T...........................151                                                      4.....................G........                                              ..............................15                                              2                                     5.....................G......................................151                                                       31.............................                                              ...............................1                                              35                                    2.....................G......................................151                                                       21.....................C.......                                              ...............................1                                              61                                    22.....................G......................................151                                                      19.............................                                              ...............................1                                              77                                    20............................................................169                                                      23.....................G.......                                              ............A...........GT.....1                                              51                                    26........TG...A.......G..T.GT....T......G..A........G.T..G...238                                                      25........TG...A..........T.GT.                                              ...T......G.CA........G.TG.G...1                                              56                                    27........TG.A.A..........T.GT....T..G...G.CAC.......GGTG.G...165                                                      28........TGTA.A..........T.GT.                                              ...........T.G..G....CG.C.A....1                                              51                                    24...C.....G........CT.G..TGGT....G........CAG.G....C.TTG.GC..169                                                      30.........G..................T                                              C...........ACAG......TTGT.....1                                              33                                    29........TG...A..........TTGT...GG..G.....C.GGG....CTCGG.....168                                                      C..............................                                              ................................       -        250       260       270       280       290       300                                                        1TACCGTATATTCTCTG-----C--GGAGGA                                              AA-------GATTTATCGCTGATGGATGAG19                                              7                                     14................-----.--........-------.....................195                                                      10................-----.--.....                                              ...-------.....................1                                              89                                    11................-----.--........-------.......T.............197                                                      3................-----.--......                                              ..-------.....................18                                              4                                     18................-----.--........-------.....................197                                                      13................-----T--.....                                              ...-------.....................1                                              97                                    7................-----.--........-------.....................199                                                       15................-----.--.....                                              ...-------.....................1                                              96                                    16................-----.--........-------.....................189                                                      8...............A-----.--......                                              ..-------.....................19                                              7                                     17...............A-----.--........-------.....................193                                                      6...............A-----.--......                                              ..-------.....................19                                              7                                     9...............A-----.--........-------.G...................197                                                       12....A..........A-----T--.....                                              ...-------.....................1                                              97                                    4...............A-----.--........-------.....................198                                                       5...............A-----.--......                                              ..-------.....................19                                              7                                     31...............A-----.--A.......-------.....................181                                                      2...............A-----.--......                                              ..-------.....................19                                              7                                     21...............A-----.--........-------.....................207                                                      22...............A-----.--A....                                              ...-------...G.................1                                              97                                    19...............A-----.--........-------...................G.223                                                      20...............A-----.--.....                                              ...-------...................G.2                                              15                                    23........GCC....A-----TAA........-------.....................199                                                      26...T.....A..C...-----.--..G..                                              ...-------...........AT.A......2                                              84                                    25...T.....A..C...-----.--..G.....-------...........AT.A......202                                                      27...T.....A..C-..-----.--..G..                                              ...-------...........AT.A......2                                              10                                    28.........CG.C..A-----.--..G.....-------A......T...AT.A......197                                                      24C..C.....CG.C...-----A--..G..                                              ...--------......T...ATCA...AG.2                                              14                                    30.........CGTC.CT-----.T-..GA....-------.........GA.G........180                                                      29.........A.....TTGGAG.AAA.C..                                              GGGATCTTCG..CC.CGT...ATAA......2                                              28                                    C*AC**TAT*+*****:     *  *G+*G***       ****T***G***+**GAT**G                  -        310       320       330       340       350       360                                                        1CCCGCGTCAGATTAGGTAGTTGGTGAGGTA                                              ATGGCTCACCAAGCCGACGATCTGTAGCTG25                                              7                                     14............................................................255                                                      10.............................                                              ...............................2                                              49                                    11............................................................257                                                      3..............................                                              ..............................24                                              4                                     18............................................................257                                                      13.............................                                              ...............................2                                              57                                    7............................................................259                                                       15.............................                                              ...A...........................2                                              56                                    16............................................................249                                                      8..............................                                              ..............................25                                              7                                     17............................................................253                                                      6..............................                                              ..............................25                                              7                                     9............................................................257                                                       12.............................                                              ..C............................2                                              57                                    4...............................C............................258                                                       5........G.....................                                              .C.........................T..25                                              7                                     31...............................C............................241                                                      2..............................                                              ...............T..............25                                              7                                     21.............................................T..............267                                                      22.............................                                              ................A..............2                                              57                                    19............................................................283                                                      20.........................T...                                              ...............................2                                              75                                    23.......G................A...........T........TGT............259                                                      26..TA...T.......C........A....                                              .......T......G.A.T.....A......3                                              44                                    25..TA...T.......C........A...........T......G.T.T.....A......262                                                      27..TAT..........C.........G...                                              ......CT......G..GT............2                                              70                                    28..TATA.T.......C.........G......A..CT......GTA.T.....A......257                                                      24.......T.......C.........G...                                              ......CT......G.........A......2                                              74                                    30.......TG......C...............G...........G........CA......240                                                      29..TA....G......C.T.......G...                                              ......CT......G.........C......2                                              88                                    CCC*******GATTAG+T*GTTGGT**GGTAA**GC*+ACCAAG+*+**GATC**TAG*TG                  -        370       380       390       400       410       420                                                        1GTCTGAGAGGATGATCAGCCACACTGGGAC                                              TGAGACACGGCCCAGACTCCTACGGGA-GG31                                              6                                     14.........................................................-..314                                                      10.............................                                              ............................-..3                                              08                                    11.........................................................-..316                                                      3..............................                                              ...........................-..30                                              3                                     18.........................................................-..316                                                      13.............................                                              ............................-..3                                              16                                    7.........................................................-..318                                                       15.............................                                              ............................-..3                                              15                                    16.........................................................-..308                                                      8..............................                                              ...........................-..31                                              6                                     17.........................................................-..312                                                      6..............................                                              ...........................-..31                                              6                                     9.........................................................-..316                                                       12.............................                                              ............................-..3                                              16                                    4.........................................................-..317                                                       5..............................                                              ...........................-..31                                              6                                     31.........................................................-..300                                                      2..............................                                              ...........................-..31                                              6                                     21.........................................................-..326                                                      22.............................                                              ............................-..3                                              16                                    19.........................................................-..342                                                      20.............................                                              ............................-..3                                              34                                    23...........C..A.........................................G-..318                                                      26...........C...............A.                                              ......T....T................-..4                                              03                                    25...........C...............A.......T....T................-..321                                                      27...........................A.                                              ...........T................-..3                                              29                                    28A..........................A.......T....T................-..316                                                      24...........................A.                                              ...........T................-..3                                              33                                    30.........................................................-..299                                                      29...........C.................                                              .......x....................-..3                                              46                                    C*TCTGAGAGGA*GA*CAGCCACACTGG*ACTGAGA**CGG*CCAGACTCCTAGGG* GG                   -        430       440       450       460       470       480                                                        1CAGCAGTGGGGAATATTGGACAATGGGCGA                                              AAGCCTGATCCAGCAATACCGAGTGAGTGA37                                              6                                     14............................................................374                                                      10.............................                                              ...............................3                                              68                                    11............................................................376                                                      3..............................                                              ..............................36                                              3                                     18............................................................376                                                      13.............................                                              ...............................3                                              76                                    7............................................................378                                                       15.............................                                              ...............................3                                              75                                    16............ ...............................................368                                                      8..............................                                              ..............................37                                              6                                     17............................................................372                                                      6..............................                                              ..............................37                                              6                                     9............................................................376                                                       12.............................                                              ...............................3                                              76                                    4............................................................377                                                       5..............................                                              ..............................37                                              6                                     31............................................................360                                                      2..............................                                              ..............................37                                              6                                     21................................CGx.........................385                                                      22.............................                                              ...............................3                                              76                                    19............................................................402                                                      20.............................                                              ...............................3                                              94                                    23...............................................G...C........378                                                      26.............................                                              ...............T..G...C........4                                              63                                    25............................................T..G...C........381                                                      27.............................                                              C..............T..G...C........3                                              89                                    28............................................C..G...CA.......376                                                      24........A....................                                              ...............C......CA.......3                                              93                                    30...........................G.C..C...........C..G...C........359                                                      29...........................G.                                              ...C..............G...C...T....4                                              06                                    CCAGCAGTG*GAATATTGGAVAATGG*G*AA***TVFATCCAGC*AT+CCG+*TG*GTGA                   -        490       500       510       520       530       540                                                        1TGAAGGCCTTAGGGTTGTAAAGCTCTTTTA                                              GCAAGGAAGA------------TAAT----42                                              0                                     14........................................------------....----418                                                      10.............................                                              ...........------------....----4                                              12                                    11........................................------------....----420                                                      3..............................                                              ..........------------....----40                                              7                                     18........................................------------....----420                                                      13.............................                                              ...........------------....----4                                              20                                    7........................................------------....----422                                                       15.............................                                              ...........------------....----4                                              19                                    16........................................------------....----412                                                      8..............................                                              ..........------------....----42                                              0                                     17........................................------------....----416                                                      6..............................                                              ..........------------....----42                                              0                                     9.................................G......------------....----420                                                       12.............................                                              ...........------------....----4                                              20                                    4........C...............................------------....----421                                                       5........C.....................                                              ..........------------....----42                                              0                                     31........C...............................------------....----404                                                      2........C.....................                                              ..........------------....----42                                              0                                     21........................................------------....----429                                                      22.............................                                              ...........------------....----4                                              20                                    19........................................------------....----446                                                      20.............................                                              ...........------------....----4                                              38                                    23...............................T.G...T..------------....----422                                                      26A.........C..........A.......                                              .AT.G......------------....----5                                              07                                    25A.........C..........A......C.AT.G......------------....----425                                                      27G....................A......C                                              ..T.G......------------....----4                                              33                                    28A.........T....................TG.......------------....----420                                                      24........C.T..................                                              ..TGG......------------....----4                                              37                                    30........C...................C.C.GGT.....------------....----403                                                      29A.........C............A....C                                              G.TGG......AATTCTCAAGGG....ATCC4                                              66                                    C*GAAGGCC*T*GGGTTGTAAA*C*CTTT***+*+*GA*GA            TAAT                      -        550       560       570       580       590       600                                                        1                                   GACGTTACTTGCAGAAAAAGCCCCGGCTAACTCCGTGCCAGCAGCCGCGGT471                         14                                                                           ...................................................469                         10                                                                           ...................................................463                         11                                                                           ...................................................471                         3                                                                            ...................................................458                         18                                                                           ...................................................471                         13                                                                           ...................................................471                         7                                                                            ...................................................473                         15                                                                           ...................................................470                         16                                                                           ...................................................463                         8                                                                            ...................................................471                         17                                                                           ...................................................467                         6                                                                            ...................................................471                         9                                                                            ...................................................471                         12                                                                           ...................................................471                         4                                                                            ...................................................472                         5                                                                            ...................................................471                         31                                                                           ...................................................455                         2                                                                            ...................................................471                         21                                                                           ....................T....x.........................479                         22                                                                           ...................................................471                         19                                                                           ...................................................497                         20                                                                           ...................................................489                         23                                                                           ...AG...C.A........................................473                         26                                                                           ....G...C.AT........T......A.......................558                         25                                                                           ....G...C.AT....G...T......A.....T.................476                         27                                                                           ....G...C.A.....G...T......A.......................484                         28                                                                           ....G....CA.....G...T..T...........................471                         24                                                                           ....G...CCA.....G...T..............................488                         30                                                                           .......ACC.G....G...............T..................454                         29TxGGGCGTT........CCA.....G....A.T..........T................525                                                      C         GAC**TA*+*+*AGAA*AAG*                                              *C*G*C*AACT**GTGCCAGCAGCCGCGGT                                                  -        610       620                                                      630       640       650                                                       660                                   1AAGACGGAGGGGGCTAGCGTTGTTCGGAATTACTGGGCGTAAAGAGTGCG-TAGGCGGTT530                                                       14.............................                                              .....................-.........5                                              28                                    10..................................................-.........522                                                      11.............................                                              .....................-.........5                                              30                                    3..................................................-.........517                                                       18.............................                                              .....................-.........5                                              30                                    13..................................................-.........530                                                      7..............................                                              ....................-.........53                                              2                                     15..................................................-.........529                                                      16.............................                                              .....................-.........5                                              22                                    8..................................................-.........530                                                       17.............................                                              .....................-.........5                                              26                                    6..................................................-.........530                                                       9..............................                                              ....................-.........53                                              0                                     12..................................................-.........530                                                      4..............................                                              ....................-.........53                                              1                                     5..................................................-.........530                                                       31.............................                                              .....................-.........5                                              14                                    2..................................................-.........530                                                       21.............................                                              .....................-.........5                                              38                                    22..................................................-.........530                                                      19.............................                                              .....................-.........5                                              56                                    20..................................................-....T....548                                                      23.............................                                              ...............G.C...-.........5                                              32                                    26..T...........A.................T...........G.CA..-....T..AC617                                                      25..T...........A..............                                              ...T...........G.CA..-....T..AC5                                              35                                    27..T...........A.................T...........G.CAT.-.........543                                                      28..T......A...........A.......                                              ...T...........G.C...-.....T.G.5                                              30                                    24..T.........................................G.....-........C547                                                      30..T...A.....................T                                              ...............C.CAT.-.......A.5                                              13                                    29..T..A...A.T..A......AA.......C.............C.C...-....T..A.584                                                      CAA+AC**AG*G*GC*AGCGTT**TCGGA*T                                              *A*TGGGCGTAAAG+G+**G TAGG**G**                                                  -        670       680                                                      690       700       710                                                       720                                   1TAGTAAGTTGGAAGTGAAAGCCCGGGGCTT-AACCTCGGAATTGCTTTCAAAACTACTAA589                                                       14.............................                                              .-............................G5                                              87                                    10..............................-.............................581                                                      11.............................                                              .-.............................5                                              89                                    3..............................-.............................576                                                       18.............................                                              .-.............................5                                              89                                    13..............................-.............................589                                                      7...........G..................                                              -.............................59                                              1                                     15..............................-.............................588                                                      16.............................                                              .-.............................5                                              81                                    8..............................-.............................589                                                       17.............................                                              .-.............................5                                              85                                    6..............................-.............................589                                                       9..............................                                              -.............................58                                              9                                     12..............................-......A......................589                                                      4..............................                                              -.............................59                                              0                                     5..............................-.............................589                                                       31.............................                                              .-.............................5                                              73                                    2..............................-.............................589                                                       21.............................                                              .-.............................5                                              97                                    22..............................-.............................589                                                      19.............................                                              .-.............................6                                              15                                    20..............................-.............................607                                                      23..A......A.G.......T...A.....                                              .-....CT....C.....CT......GT..G5                                              91                                    26.........AA........TA..AAA...C-...T.T...GC......T..T...G...G676                                                      25.........AA........TA..AA....                                              .-...T.T...GCG.....T..T...G...G5                                              94                                    27.G.......AA.G......TA..A......-....CT..GGC......T..T...G.AGG602                                                      28..A......AA........T....A....                                              .-.....T...........T.......T...5                                              89                                    24CC.......A.GT......T..TT......-....CAA...C...A..T......GTGGG606                                                      30ATT.....CA..G......T...A.....                                              -C....CT....C...C..TG.T...GGATG5                                              72                                    29ATT.....C...T..........T.....-xxx...G........ACC.G.T...GGGT.640                                                      C***TAAGT*+***GTGAAA+*C*+**GCT*                                               **C**+*G****GC***+*A*ACT+***+                                                  -        730       740                                                      750       760       770                                                       780                                   1TCTAGAGTGTAGTAGGGGATGATGGAATTCCTAGTGTAGAGGTGAAATTCTTAGATATTA649                                                       14.............................                                              ...............................6                                              47                                    10............................................................641                                                      11.............................                                              ...............................6                                              49                                    3............................................................636                                                       18.............................                                              ...............................6                                              49                                    13............................................................649                                                      7..............................                                              ..............................65                                              1                                     15............................................................648                                                      16.............................                                              ...............................6                                              41                                    8............................................................649                                                       17.............................                                              ...............................6                                              45                                    6........A...................................................649                                                       9..............................                                              ..............................64                                              9                                     12............................................................649                                                      4..............................                                              ..............................65                                              0                                     5............................................................649                                                       31.............................                                              ...............................6                                              33                                    2............................................................649                                                       21.............................                                              ...............................6                                              57                                    22............................................................649                                                      19.............................                                              ...............................6                                              75                                    20............................................................667                                                      23G.......A.G....A..G..........                                              T.............A................6                                              51                                    26A......GTCGAG..A....AGC...........................G.........736                                                      25A......GTCGAA..A....AGC......                                              .....................G.........6                                              54                                    27A.......CCG.A..A....AGC...........................G.........662                                                      28.......AT.GAA..A....AGA......                                              ...GA.........A......G..A......6                                              49                                    24A..C..AC..GAG..A..GCA........TT.G......G........C.G.......C.666                                                      30...C......G.A..A..TGAG.......                                              ..G...........A......G........C6                                              32                                    29...T....A.G....A..GAAx.......T.CG......C........G.G.......CG699                                                      C*CT*GA**+*+**AG+GG**+**GGAATT*                                              ****TGTAG*GGT*AAAT*C+TA*ATAT**                                                  -        790       800                                                      810       820       830                                                       840                                   1GGAGGAACACCGGTGGCG--AAGGCGGTCATCTGGGCTACCACTGACGCTGATGCACGAA707                                                       14...........A......--.........                                              ...........A...................7                                              05                                    10..................--....................A...................699                                                      11..................--......A..                                              ...........A...................7                                              07                                    3..................--....................A...................694                                                       18..................--.........                                              ...........A...................7                                              07                                    13..................--....................A...................707                                                      7..................--..........                                              ..........A...................70                                              9                                     15..................--.........G..........A...................706                                                      16..................--.........                                              ...........A...................6                                              99                                    8..................--....................A...................707                                                       17..................--.........                                              ...........A...................7                                              03                                    6..................--....................A...................707                                                       9..................--..........                                              ........G.A...................70                                              7                                     12..................--......A.............A...................707                                                      4..................--..........                                              ..........A...................70                                              8                                     5..................--....................G...................707                                                       31..................--.........                                              ...........A...................6                                              91                                    2..................--....................A...................707                                                       21..................--.........                                              ......x....A.........x.........7                                              13                                    22..................--......A......A.....TA...................707                                                      19..................--.........                                              ...........A...................7                                              33                                    20..................--....................A..............x....724                                                      23.A.........A......--..A..T...                                              ........C.TT...........G..G....7                                              09                                    26..................--.......CT......CTCGAT......A....G.TG....794                                                      25...........A......--..A....CT                                              ......TTCGAT......A....G.TG....7                                              12                                    27...........A......--.......CTG.....T.CGGT...........G.TG....720                                                      28...........A......--......TCT                                              ......TTC.AAT..........A..G....7                                              07                                    24A.......GT.A.G....--.. ...A.TGC....ATC..AGT.........G.......724                                                      30...........A......--.                                                      .....CTCA....T.C.TT...........G.                                              TG....690                             29.A.A.......A.....--G. ....ACTTC....A.C.AT......A....G..G....757                                                      C**A*GAAC**C+G*GGC*  AA*GC***+*                                              *CT*G+*+*++**TGAC*CT*A+G*+CGAA                                                  -        850       860                                                      870       880       890                                                       900                                   1AGCGTGGGGAGCAAACAGGATTAGATACCCTGGTAGTCCACGCCGTAAACGATGAGTGCT767                                                       14.............................                                              ...............................7                                              65                                    10............................................................759                                                      11.............................                                              ...............................7                                              67                                    3............................................................754                                                       18.............................                                              ...............................7                                              67                                    13............................................................767                                                      7..............................                                              ..............................76                                              9                                     15............................................................766                                                      16.............................                                              ...............................7                                              59                                    8............................................................767                                                       17.............................                                              ...............................7                                              63                                    6............................................................767                                                       9..............................                                              ..............................76                                              7                                     12............................................................767                                                      4..............................                                              ..............................76                                              8                                     5............................................................767 -                                                    31..............................                                              ..............................75                                              1                                     2............................................................767                                                       21.............................                                              ...............................7                                              73                                    22............................................................767                                                      19.............................                                              ...............................7                                              93                                    20............................................................784                                                      23.............................                                              ..............T................7                                              84                                    26...........................................T................854                                                      25.............................                                              ..T...........T................7                                              72                                    27...........................................T................780                                                      28G............................                                              ..............T...........A..T.7                                              67                                    24...........................................T..............T.784                                                      30.............................                                              ..........................A..T.7                                              50                                    29.........................G.................x..C.........AA..816                                                      C*GCGTGGGGAGCAAACAGGATTAGA*ACCC                                              T*GTAGTCCACGC+GT*AACGATGA****T                                                  -        910       920                                                      930       940       950                                                       960                                   1                                                                            AGATATCGGAA----GATTCT-CTTTCGGTTTCGCAGCTAACGCATTAAGCACTCCGCC821                 14                                                                           ...........----......-.....................................819                 10                                                                           ...........----......-............T........................813                 11                                                                           ...........----......-.....................................821                 3                                                                            ...........----......-.....................................808                 18                                                                           ...........----..G...-.....................................821                 13                                                                           ...........----....T.-.....................................821                 7                                                                            ...........----......-.....................................823                 15                                                                           ...........----......-.....................................820                 16                                                                           ...........----......-.....................................813                 8                                                                            ...........----......-.....................................821                 17                                                                           ...........----......-.....................................817                 6                                                                            ...........----......-.....................................821                 9                                                                            ...........----......-.....................................821                 12                                                                           ...........----......-.....................................821                 4                                                                            ...........----....T.-.....................................822                 5                                                                            ...........----..G...-.....................................821                 31                                                                           ...........----......-.....................................805                 2                                                                            ......T..G.----....T.-..C..................................821                 21                                                                           ..........-----..A...-..C...........CG.....................826                 22                                                                           .........G.----..A.A.-..C..................................821                 19                                                                           ..........G----......-.....................................847                 20                                                                           ..........G----......-.....................................838                 23                                                                           ......T..GG----....T.T.....A......T........................824                 26                                                                           .A..G.-.AGG----A--.T.TA.C.TT..A.T.T.........G..............906                 25                                                                           .A..G.-.AGG----A--.T.TA.C.TT..A.T.T.........G..............824                 27                                                                           GA..G.-..GG----.C..T.-GCC..T..G.T.T.........G..............833                 28                                                                           .A....G..G.----.--.T.A.....T..A.TA..........G....A..T......820                 24                                                                           .A.AG.-.-GG----TTA.T.TA.C.--.C..T.T.........G....A.........835                 30                                                                           ..CCG....GT----.G..TACTAC.....GG....CG......G....A..T......805                 29                                                                           ..C.G.T..----GAAG...CCT.C.TA..AG..A.........G.....TT.......871                 C*****T+G*++    *++T+* **+T*+G*****+A**TAACGC+TTAA****TCCGCC                   -        970       980       990      1000      1010      1020                                                        1TGGGGAGTACGGTCGCAAGATTAAAACTCA                                              AAGGAATTGACGGGGGCTCGCACAAGCGGT88                                              1                                     14............................................................879                                                      10.............................                                              ...............................8                                              73                                    11............................................................881                                                      3..............................                                              ..............................86                                              8                                     18............................................................881                                                      13.............................                                              ...............................8                                              81                                    7............................................................883                                                       15.............................                                              ...............................8                                              80                                    16............................................................873                                                      8..............................                                              ..............................88                                              1                                     17............................................................877                                                      6..............................                                              ..............................88                                              1                                     9............................................................881                                                       12.............................                                              ...............................8                                              81                                    4............................................................882                                                       5..............................                                              ..............................88                                              1                                     31............................................................865                                                      2..............................                                              ..............................88                                              1                                     21............................................................886                                                      22.............................                                              ...............................8                                              81                                    19............................................................907                                                      20.............................                                              ...............................8                                              98                                    23...............................................C............884                                                      26......C.............C........                                              ................A.C............9                                              66                                    25......C.............C........................A.C..........-.883                                                      27......C.............C........                                              ................A.x............8                                              92                                    28......C......................................A.C............880                                                      24......C.............C........                                              ................A..............8                                              95                                    30...............................................C..........-.864                                                      29............C......G.........                                              ...A..............x............9                                              30                                    CTGGGGA*TACGG*CGCAAG**TAAAACTCAAAG*AATTGACGGGG*C+CGCACAAGCG*T                  -       1030      1040      1050      1060      1070      1080                                                        1GGAGCATGCGGTTTAATTCGATGTTACGCG                                              AAAAACCTTACCAACCCTTGACATGGTGGT94                                              1                                     14............................................................939                                                      10.............................                                              ...............................9                                              33                                    11............................................................941                                                      3..............................                                              ..............................92                                              8                                     18............................................................941                                                      13.............................                                              ...............................9                                              41                                    7............................................................943                                                       15.............................                                              ...............................9                                              40                                    16............................................................933                                                      8..............................                                              ..............................94                                              1                                     17............................................................937                                                      6..............................                                              ..............................94                                              1                                     9............................................................941                                                       12.............................                                              ...............................9                                              41                                    4................................G...........................942                                                       5..............................                                              ................T.............94                                              1                                     31............................................................925                                                      2..............................                                              ..............................94                                              1                                     21............................................................946                                                      22.............................                                              ...............................9                                              41                                    19............................................................967                                                      20.............................                                              ...............................9                                              58                                    23.......................A.C...................T...........A..944                                                      26........T..............CA....                                              ..............CTTT........AA...1                                              026                                   25........T..............CA..................CTTT........AA...943                                                      27........T..............CA....                                              ..............CTT..........A..C9                                              52                                    28........T..............CA..................CTT.........AAAA.940                                                      24....T...T..............CA....                                              ..............TA..........TG.A.9                                              55                                    30........T............A.CA.....C.G..........G..........CCC.A.924                                                      29........T..............CA....                                              .............T...........CC.C.-9                                              89                                    CGGAG*ATG+GGTTTAATTCGA*G++*CGCG*A*AACCTTACC*****TTGACAT******                  -       1090      1100      1110      1120      1130      1140                                                        1TGCGGATCGCAGAGATGCTTTTCTTCAGCT                                              CGGCTGGACCACAC-ACAGGTGTTGCATGG10                                              00                                    14C...........................................-...............998                                                      10C............................                                              ...............-...............9                                              92                                    11C.....................................T.....-...............1000                                                     3C.............................                                              ..............-...............98                                              7                                     18C...........................................-...............1000                                                     13C............................                                              ...............-...............1                                              000                                   7C...........................................-...............1002                                                      15C............................                                              ...............-...............9                                              99                                    16C.T.........................................-...............992                                                      8C.............................                                              ..............-...............10                                              00                                    17C...........................................-...............996                                                      6C.............................                                              ..............-...............10                                              00                                    9C.T.A.......................................-...............1000                                                      12C....................C.......                                              ...............-...............1                                              000                                   4.....................C......................-...............1001                                                      5.....................C......T.                                              ..............-...............10                                              00                                    31C....................C......................-...............984                                                      2C....................C......T.                                              ..............-...............10                                              00                                    21C....................C......T...............-...............1005                                                     22C......T.............C......T                                              ...............-...............1                                              000                                   19.A.....T.............C......T........G......-...............1026                                                     20.AT....T.............C......T                                              ........G......-...............1                                              017                                   23C...A.AAATG....CAT..........T.T........T....-...............1003                                                     26C.TATCC.TTTT.-.CCGAGGGAG....T                                              ...........TT..-.......C.......1                                              084                                   25C.TATCC.T.CT.-..AGGGGGAG....T...........TT..-.......C.......1001                                                     27.AGATCCTT.TT.-.CAGAAGGGCG...T                                              ........G..T.G.-.......C.......1                                              010                                   28CATACC.ATTC..-.G.GA.AGGG..G.T.....C...TTTT..-...A...........998                                                      24..TATCC.T.T..-.G.GAGGGAG....T                                              .........T.CA..-...............1                                              013                                   30C.....AG.TG....CA.CC.C......T.A.......T.GGTG-.......C.......983                                                      29                                  .AACT.GT........A...GG.G.C-T....--.A...GAGTG.......C.......1045                C+*+*+**++*+*A*A**+***:***C**:T*GG**G****+*** ACA*GTG*TGCATGG                  -       1150      1160      1170      1180      1190      1200                                                        1CTGTCGTCAGCTCGTGTCGTGAGATGTTGG                                              GTTAAGTCCCGCAACGAGCGCAACCCTCAT10                                              60                                    14............................................................1058                                                     10.............................                                              ...............................1                                              052                                   11............................................................1060                                                     3..............................                                              ..............................10                                              47                                    18............................................................1060                                                     13.............................                                              ...............................1                                              060                                   7............................................................1062                                                      15.............................                                              ...............................1                                              059                                   16............................................................1052                                                     8..............................                                              ..............................10                                              60                                    17............................................................1056                                                     6..............................                                              ..............................10                                              60                                    9............................................................1060                                                      12.............................                                              ...............................1                                              060                                   4............................................................1061                                                      5..............................                                              ..............................10                                              60                                    31............................................................1044                                                     2..............................                                              ..............................10                                              60                                    21............................................................1065                                                     22.............................                                              ...............................1                                              060                                   19.........................................................T..1086                                                     20.............................                                              ............................T..1                                              077                                   23.........................................................T..1063                                                     26.............................                                              ...............................1                                              144                                   25............................................................1061                                                     27.............................                                              ...............................1                                              070                                   28............................................................1058                                                     24.............................                                              ...............................1                                              073                                   30..........................................................GC1043                                                     29.............................                                              ...........T.................G.1                                              105                                   CCTGTCGTCAGCTCGTGTCGTGAGATGTTGGGTTAAGTCCCG*AACGAGCGCAACCCT***                  -       1210      1220      1230      1240      1250      1260                                                        1TCTTATTTGCCAGCGGGTAATGCCGGGAAC                                              TATAAGAAAACTGCCGGTGATAAGCCG-GA11                                              19                                    14.........................................................-..1117                                                     10.............................                                              ............................-..1                                              111                                   11.........................................................-..1119                                                     3..............................                                              ...........................-..11                                              06                                    18.........................................................-..1119                                                     13.............................                                              ............................-..1                                              119                                   7.........................................................-..1121                                                      15.............................                                              ............................-..1                                              118                                   16.........................................................-..1111                                                     8..............................                                              ...........................-..11                                              19                                    17.........................................................-..1115                                                     6..............................                                              ...........................-..11                                              19                                    9.........................................................-..1119                                                      12........................A....                                              ............................-..1                                              119                                   4.........................................................-..1120                                                      5..............................                                              ...........................-..11                                              19                                    31.........................................................-..1103                                                     2..............................                                              ...........................-..11                                              19                                    21........................A................................-A-1123                                                     22................A............                                              ................A.........T.-..1                                              119                                   19.............T...........................................-..1145                                                     20.............................                                              ............................-..1                                              136                                   23..................................G..............C.......-..1122                                                     26C....G..A...A.A........T...C.                                              ..C....G........A.......A.T.-..1                                              203                                   25C....G..A...A.A........T...C...C....G........A.......A.T.-..1120                                                     27C....G..A..................C.                                              ..T....G........A.......A.T.-..1                                              129                                   28C....G......T.A........T.A.T...T....G........A.........T.-..1117                                                     24C....G..........T.CG-........                                              ..T....G........A....C....T.-..1                                              131                                   30C....G......T.ATTA.G.--T...C...C..G.GGG..................A..1101                                                     29C....G.........A..C.A.T......                                              ..C....G.G..............A...-..1                                              164                                   C+CTTA+TT*CCA**************G*ACT+TA*G+**ACTGCC*GTG**AA*C*G **                  -       1270      1280      1290      1300      1310      1320                                                        1GGAAGGTGGGGACGACGTCAAGTCATCATG                                              GCCCTTACGGGTTGGGCTACACGCGTGCTA11                                              79                                    14............................................................1177                                                     10.............................                                              ...............................1                                              171                                   11............................................................1179                                                     3..............................                                              ..............................11                                              66                                    18............................................................1179                                                     13.............................                                              ...............................1                                              179                                   7............................................................1181                                                      15.............................                                              ...............................1                                              178                                   16............................................................1171                                                     8............T.................                                              ..............................11                                              79                                    17............T................................................1175                                                    6..............................                                              ..............................11                                              79                                    9............................................................1179                                                      12.............................                                              ...............................1                                              179                                   4............................................................1180                                                      5..............................                                              .......T......................11                                              79                                    31............................................................1163                                                     2..............................                                              ..............................11                                              79                                    21                                                                           ...............................................G...........1182                22............................................................1179                                                     19.............................                                              ...............................1                                              205                                   20............................................................1196                                                     23............T..G.............                                              ........T.A....................1                                              182                                   26............T..T.........G..C........TA..G..........A.......1263                                                     25............T..T.........G..C                                              ........TAA.G..........A.......1                                              180                                   27............T..T.........G..C........T...G..........A.......1189                                                     28............T..T.............                                              ....T...T..AG..........A.......1                                              177                                   24.....................................T..TA..........A...A...1191                                                     30............T...........C....                                              ............C..........A.......1                                              161                                   29............T..T..........................A.........A.......1224                                                     C*GAAGGTGGGGA+GA*GTCAAGTC**CA*G                                              GCC*TTA+*****GGGCT*CAC+CGT*CTA                                                  -       1330      1340                                                      1350      1360      1370                                                      1380                                  1CAATGGTGTTTACAG-AGGGAAGCAAGACG-GCGACGTGGAGCAAATCCC-TAAAAGACA1236                                                      14...............-.............                                              .-...................-.........1                                              234                                   10...............-..............-...................-.........1228                                                     11...............-.............                                              .-...................-.........1                                              236                                   3...............-..............-...................-.........1223                                                      18...............-.............                                              .-...................-.........1                                              236                                   13...............-..............-...................-.........1236                                                     7...............-..............                                              -...................-.........12                                              38                                    15...............-..............-...................-.........1235                                                     16...............-.............                                              .-...................-.........1                                              228                                   8...............-..............-...................-.........1236                                                      17...............-.............                                              .-...................-.........1                                              232                                   6...............-..............-...................-.........1236                                                      9...............-..............                                              -...................-.........12                                              36                                    12...............-..............-...................-.........1236                                                     4...............-..............                                              -...................-.........12                                              37                                    5...............-..............-.TA................-.........1236                                                      31...............-.............                                              .-...................-.........1                                              220                                   2...............-..............-...................-.........1236                                                      21...............-.............                                              .-...................-.........1                                              239                                   22...............-..........A...-...................-.........1236                                                     19...............-..........T..                                              .-.T.................-.........1                                              262                                   20...............-..............-.T.................-.........1253                                                     23.......ACC.....-..T..T..G.T..                                              .-.T..........T....AT-......GT.1                                              239                                   26......CAAC....AT...TT-..G....C-....G..TT...T....-.AA.....TTG1320                                                     25......CAAC....AT...TC-..G....                                              C-..A.G..TT...T....-.A......TTG1                                              237                                   27......C.AC....AT...TT-....CGTC-..A.G.CT....T....-.G......T.G1246                                                     28.........C....AT-...CT.....GT                                              .C..A.GCCTA...T......-.........1                                              235                                   30........G.G....T-...C...G....C-....G..C....T....T.-C.....C..1218                                                     29......GCAG....A-....TT..C.-.G                                              CC....G.......T......AG....CTGC1                                              282                                   CCAATGG**++*ACA* ****+*GC*A**** G**A+*****GC+AATC** *AAA**+**                  -       1390      1400      1410      1420      1430      1440                                                        1TCTCAGTTCGGATTGTTCTCTGCAACTCGA                                              GAGCATGAAGTT-GGAATCGCTAGTAATCG12                                              95                                    14..........................................-.................1293                                                     10.............................                                              .............-.................1                                              287                                   11..........................................-.................1295                                                     3..............................                                              ............-.................12                                              82                                    18..........................................-.................1295                                                     13.............................                                              .............-.................1                                              295                                   7..........................................-.................1297                                                      15.............................                                              .............-.................1                                              294                                   16..........................................-.................1287                                                     8..............................                                              ............-.................12                                              95                                    17..........................................-.................1291                                                     6..............................                                              ............-.................12                                              95                                    9..........................................-.................1295                                                      12.............................                                              .............-.................1                                              295                                   4..........................................-.................1296                                                      5..............................                                              ............-.................12                                              95                                    31..........................................-.................1279                                                     2..............................                                              ............-.................12                                              95                                    21...............C..........................-.................1298                                                     22.............................                                              .............-.................1                                              295                                   19..........................................-.................1321                                                     20.............................                                              .............-.................1                                              312                                   23...............CA..............T.........C-.................1298                                                     26.............................                                              ............C-.................1                                              379                                   25.........................................C-.................1296                                                     27................C.....T......                                              ..G.........C-.................1                                              305                                   28................A..............TA.........-.................1294                                                     24.......A.......CCT...........                                              .AG..........-.................1                                              309                                   30...............CA..............T..........-.................1277                                                     29..GT...C.......GAG...........                                              .CTC........-T.................1                                              341                                   CTC**AGT*CGGATTG***TCTG*AACTCGA***CATGAAGT* GGAATCGCTAGTAATCG                  -       1450      1460      1470      1480      1490      1500                                                        1CGGATCAGCATGCCGCGGTGAATACGTTCT                                              CGGGCCTTGTACACACTGCCCGTCACGCCA13                                              55                                    14............................................................1353                                                     10.............................                                              ...............................1                                              347                                   11............................................................1355                                                     3..............................                                              ..............................13                                              42                                    18............................................................1355                                                     13.............................                                              ...............................1                                              355                                   7............................................................1357                                                      15.............................                                              ...............................1                                              354                                   16............................................................1347                                                     8..............................                                              ..............................13                                              55                                    17............................................................1351                                                     6..............................                                              ..............................13                                              55                                    9............................................................1355                                                      12.............................                                              ...............................1                                              355                                   4............................................................1356                                                      5..............................                                              ..............................13                                              55                                    31............................................................1339                                                     2..............................                                              ..............................13                                              55                                    21............................................................1358                                                     22.............................                                              ...............................1                                              355                                   19............................................................1381                                                     20.............................                                              ...............................1                                              372                                   23......................................................G.A...1358                                                     26T.....T......A...............                                              ....T..........................1                                              439                                   25T.....T......A...................T..........................1356                                                     27T............A...............                                              ....T..........................1                                              365                                   28T............A................------------------------------1325                                                     24.A..........T................                                              ....T.....................G....1                                              369                                   30T............A...............C................C.........A...1337                                                     29..A.........T................                                              .................C.........A...1                                              401                                   C***ATCA*CATG***CGGTGAATACGTTC*C*****************************                  -       1510      1520      1530      1540      1550      1560                                                        1TGGGAGTTAGTTTTACCTGAAGGTGGTGAG                                              CTAAC-G-CAAG-AGGCAGCCAACCACGGT14                                              12                                    14...................................-.-....-.................1410                                                     10.............................                                              ......-.-....-.................1                                              404                                   11........G..........................-.-....-.................1412                                                     3..............................                                              .....-.-....-.................13                                              99                                    18...................................-.-....-.................1412                                                     13.............................                                              ......-.-....-.................1                                              412                                   7...................................-.-....-.................1414                                                      15.............................                                              ......-.-....-.................1                                              411                                   16...................................-.-....-.................1404                                                     8........G.....................                                              .....-.-....-.................14                                              12                                    17........G..........................-.-....-.................1408                                                     6........G..................A..                                              .....-.-....-.................14                                              12                                    9........G..........................-.-....-.................1412                                                      12........G....................                                              ......-.-....-.................1                                              412                                   4........G..........................-.-....-.................1413                                                      5........G.....................                                              .....-.-....-.................14                                              12                                    31........G..........................-.-....-.................1396                                                     2........G.....................                                              .....-.-....-.................14                                              12                                    21........G...................G......C.-....-.................1416                                                     22........G....................                                              ......-.-....-.................1                                              412                                   19........G..........................-.-....-.................1438                                                     20........G....................                                              ......-.-....-.................1                                              429                                   23.......C...GG.........T............-.-T...-.......T.........1415                                                     26.....A..G.C..A..TC....C.....T                                              ......C.-T...G.A.......TTT.A...1                                              498                                   25.....A..G.C..A..TC....C.....T......C.-....G.A.......TTT.A...1415                                                     27.....A..G.C..A..TC....C.....C                                              ..C...C.-T...G.........TTT.A...1                                              424                                   28                                                                           1325                                                                           24........CA.C....TC....C.A.......G..C.-....G.......T.T.T.....1428                                                     30........G........C.......C..T                                              ......C.-....G......G..........1                                              396                                   29.......G.A..G....A....CG...AG......CTT.GG.AG.C.-..TC........1460                                                     C********:********+****+*****+*                                              *****.* **** *****************                                                  -       1570      1580                                                      1590      1600      1610                                                      1620                                  1AAAATTAGCGACTGGGGTGAAGTCGTAA--------------------------------1440                                                      14............................-                                              -------------------------------1                                              438                                   10............................--------------------------------1432                                                     11............................-                                              -------------------------------1                                              440                                   3............................--------------------------------1427                                                      18............................-                                              -------------------------------1                                              440                                   13............................--------------------------------1440                                                     7............................--                                              ------------------------------14                                              42                                    15............................--------------------------------1439                                                     16............................-                                              -------------------------------1                                              432                                   8............................--------------------------------1440                                                      17............................-                                              -------------------------------1                                              436                                   6............................--------------------------------1440                                                      9............................--                                              ------------------------------14                                              40                                    12............................--------------------------------1440                                                     4............................--                                              ------------------------------14                                              41                                    5.G..........................--------------------------------1440                                                      31............................-                                              -------------------------------1                                              408                                   2............................--------------------------------1440                                                      21............................-                                              -------------------------------1                                              435                                   22............................--------------------------------1440                                                     19............................C                                              AAGGTAGCCGTAGGGGAACCTGCGGCTGGAT1                                              498                                   20............------------------------------------------------1441                                                     23.G..C.G.T.........A.........C                                              AAGG---------------------------1                                              448                                   26TGGG....T....A..............CAAGGTAGCTGTAGGTGAACCTGCGGCTGGAT1558                                                     25TGGG....T....A.....----------                                              -------------------------------1                                              434                                   27TGGG.CG.T...................CAAGGTAGCTGTAGGTGAACCTGCGGCTGGAT1484                                                     28                                  1325                                                                           24GGGG.GG.T.........T.........CAAGGTAGCCGTAGGTGAACCTGCGGCTGGAT1488                                                     30.GGG.C.............----------                                              -------------------------------1                                              415                                   29.TG..CCAx...------------------------------------------------1471                                                     C++++++++++++++++++++++++++++                                                  -       1630                        1                                                                            1440                                                                           14                                                                           1438                                                                           10                                                                           1432                                                                           11                                                                           1440                                                                           3                                                                            1427                                                                           18                                                                           1440                                                                           13                                                                           1440                                                                           7                                                                            1442                                                                           15                                                                           1439                                                                           16                                                                           1432                                                                           8                                                                            1440                                                                           17                                                                           1436                                                                           6                                                                            1440                                                                           9                                                                            1440                                                                           12                                                                           1440                                                                           4                                                                            1441                                                                           5                                                                            1440                                                                           31                                                                           1408                                                                           2                                                                            1440                                                                           21                                                                           1435                                                                           22                                                                           1440                                                                           19TACCTCCTTA-1508                                                             20                                                                           1441                                                                           23                                                                           1448                                                                           26TACCTCCTTTT1569                                                             25                                                                           1434                                                                           27CACCTCCTT--1493                                                             28                                                                           1325                                                                           24TACCTCCTTT-1498                                                             30                                                                           1415                                                                           29                                                                           1471                                                                         __________________________________________________________________________

The single-stranded nucleotide fragment of the invention has anucleotide sequence of at least 5 consecutive nucleotides chosen fromthe following sequences:

starting at nucleotide No. 130 and ending at nucleotide No. 170

starting at nucleotide No. 181 and ending at nucleotide No. 201

starting at nucleotide No. 241 and ending at nucleotide No. 272

starting at nucleotide No. 284 and ending at nucleotide No. 298

starting at nucleotide No. 299 and ending at nucleotide No. 315

starting at nucleotide No. 334 and ending at nucleotide No. 357

starting at nucleotide No. 460 and ending at nucleotide No. 481

starting at nucleotide No. 504 and ending at nucleotide No. 536

starting at nucleotide No. 550 and ending at nucleotide No. 570

starting at nucleotide No. 561 and ending at nucleotide No. 585

starting at nucleotide No. 661 and ending at nucleotide No. 684

starting at nucleotide No. 710 and ending at nucleotide No. 739

starting at nucleotide No. 903 and ending at nucleotide No. 929

starting at nucleotide No. 940 and ending at nucleotide No. 960

starting at nucleotide No. 1035 and ending at nucleotide No. 1055

starting at nucleotide No. 1078 and ending at nucleotide No. 1107

starting at nucleotide No. 1199 and ending at nucleotide No. 1213

starting at nucleotide No. 1330 and ending at nucleotide No. 1350

starting at nucleotide No. 1361 and ending at nucleotide No. 1387

starting at nucleotide No. 1429 and ending at nucleotide No. 1463

starting at nucleotide No. 1501 and ending at nucleotide No. 1520

starting at nucleotide No. 1555 and ending at nucleotide No. 1576

and their complementary sequences.

The invention relates especially to the single-stranded nucleotidefragments having a sequence of at least 8, and in particular of at least10, consecutive nucleotides which is chosen from the abovementionedsequences (or from complementary sequences). Of course, the inventionextends to any nucleotide fragment which is sufficiently homologous to afragment as defined above to be capable of hybridizing specifically withRickettsia rDNA or rRNA.

More particularly, the nucleotide sequences of the fragments of theinvention are chosen from the sequences SEQ ID NO 1 to SEQ ID NO 22,which are described at the end of the description, or theircomplementary sequences.

The numbering of the sequence of the 16S rRNA of R. rickettsii, appliedto the sequences SEQ ID NO 1 to SEQ ID NO 22 above, does not alwaysreflect the number of nucleotides or monomers constituting thesesequences because of the size variations existing between the sequencesand the sequence of the 16S rRNA of R. rickettsii. The variations aredue to natural insertions or deletions in the genetic material.

In accordance with the above definition, the fragments of the inventionare DNA fragments, but they may also be single-stranded RNA fragments,or their complementary fragments, as well as single-stranded genomic DNAfragments whose transcription products are the abovementioned RNAfragments, or their complementary fragments.

The single-stranded nucleotide fragments of the invention can be used inparticular as probes, especially as capture or detection probes,according to known hybridization techniques.

The probes specific for the genus Rickettsia are especially those havinga sequence chosen from the sequences:

starting at nucleotide No. 181 and ending at nucleotide No. 201

starting at nucleotide No. 284 and ending at nucleotide No. 298

starting at nucleotide No. 561 and ending at nucleotide No. 585

starting at nucleotide No. 940 and ending at nucleotide No. 960

starting at nucleotide No. 1199 and ending at nucleotide No. 1213

starting at nucleotide No. 1429 and ending at nucleotide No. 1463

and their complementary sequences, or their analogues.

The probes for the species R. tsutsugamushi are especially those havinga sequence chosen from the sequences:

starting at nucleotide No. 130 and ending at nucleotide No. 170

starting at nucleotide No. 241 and ending at nucleotide No. 272

starting at nucleotide No. 299 and ending at nucleotide No. 315

starting at nucleotide No. 334 and ending at nucleotide No. 357

starting at nucleotide No. 460 and ending at nucleotide No. 481

starting at nucleotide No. 504 and ending at nucleotide No. 536

starting at nucleotide No. 550 and ending at nucleotide No. 570

starting at nucleotide No. 661 and ending at nucleotide No. 684

starting at nucleotide No. 710 and ending at nucleotide No. 739

starting at nucleotide No. 903 and ending at nucleotide No. 929

starting at nucleotide No. 1035 and ending at nucleotide No. 1055

starting at nucleotide No. 1078 and ending at nucleotide No. 1107

starting at nucleotide No. 1330 and ending at nucleotide No. 1350

starting at nucleotide No. 1361 and ending at nucleotide No. 1387

starting at nucleotide No. 1501 and ending at nucleotide No. 1520

starting at nucleotide No. 1555 and ending at nucleotide No. 1576

and their complementary sequences, or their analogues.

Another subject of the invention is a therapy probe for the treatment ofinfections caused by bacteria of the genus Rickettsia and especially atherapy probe for the treatment of infections caused by a determinedspecies of Rickettsia, both comprising at least one single-strandednucleotide fragment as defined above.

Another subject of the invention is a primer for the specific reversetranscription to a DNA sequence complementary to a Rickettsia 16Sribosomal RNA sequence belonging either to a region conserved only inRickettsia, or to a region specific for the species R. tsutsugamushi; ora primer, especially for the specific amplification of a DNA or RNAsequence complementary or homologous to the sequence of the Rickettsia16S ribosomal RNA, belonging either to a region conserved only inRickettsia, or to a region specific for the species R. tsutsugamushi.Such a primer comprises or consists of a single-stranded nucleotidefragment as defined above.

The invention also relates to a reagent for detecting and/or identifyingat least one species of Rickettsia in a biological sample comprising atleast one probe of the invention, and in particular a capture probeand/or a detection probe corresponding to the definition of a probegiven above. The reagent may comprise a mixture of probes.

Finally, the invention provides a process for detecting and/oridentifying at least one species of Rickettsia in a biological sampleaccording to which either ribosomal RNA, in particular 16S rRNA,extracted from rickettsias and optionally denatured, or genomic DNA,extracted and denatured, from the bacteria, or alternatively the DNAobtained from the reverse transcription of the 16S ribosomal RNA isbrought into contact with at least one probe of the invention, and thenthe possible hybridization of the said probe is detected in a mannerwhich is known per se.

Of course, it is advisable to carry out the hybridization underconditions which are sufficiently discriminating (stringency) for thehybridization of at least one of the probes to be specific.

If desired, before exposing the nucleic acid to the probe of theinvention, this nucleic acid is amplified in the presence of a suitableenzymatic system and of at least one amplification primer of theinvention.

The invention relates in particular to a process for the detectionand/or identification of Rickettsia in a biological sample,characterized in that it comprises:

a--the bringing of the said sample into contact with at least onesingle-stranded nucleotide fragment as defined above under predeterminedconditions which allow the said fragment to hybridize to the rDNA orrRNA of a bacterium of the genus Rickettsia, if present; and

b--the detection of the said hybrid as an indicator of the presence ofRickettsia in the sample.

Of course, the predetermined hybridization conditions are those whichallow a specific hybridization.

The following examples illustrate the invention.

EXAMPLE 1

Determination of the nucleotide sequence of the DNA corresponding to the16S ribosomal RNA of rickettsias. The nucleotide sequence of the DNAcorresponding to the 16S ribosomal RNA of the following 16 strains wasdetermined:

    ______________________________________                                        R. tsutsugamushi  ATCC       Gilliam                                          R. canada         Gamaleya Research Institute                                    Collection 2678                                                            R. conorii        ATCC       VR-141                                             R. akari ATCC VR-148                                                          R. mooseri ATCC VR-144                                                        R. australis                                                                  R. rhipicephali                                                               R. montana                                                                    R. bellii                                                                     R. japonica                                                                   R. parkeri                                                                    R. helvetica                                                                  R. sibirica ATCC VR-151                                                       R. massiliae                                                                  R. slovaca                                                                  R. africae        Gamaleya Research Institute                                    Collection                                                                 ______________________________________                                    

The total DNA of the strains was isolated according to the techniquedescribed by Maniatis et al. (Molecular cloning, Cold Spring Harbor,1982). PCR amplification products were generated from the genomic DNAisolated from these strains with the aid of amplification primers chosenfrom conserved regions in the known sequences of R. rickettsii, R. typhiand R. prowazekii.

The amplification products obtained were purified on magnetic beadslabelled with streptavidin (Dynabead M-280; Dynal Inc., N.Y.) andsequenced using the technique recommended in the commercial kit"Autoread sequencing kit".

EXAMPLE 2

Use of a specific probe directed against the 16S ribosomal RNA for theidentification of R. tsutsugamushi. The probe starting at nucleotide No.903 and ending at nucleotide No. 929 of SEQ ID NO 13 is specific for theR. tsutsugamushi strains. A collection of rickettsia strains was testedby hybridization on the 16S ribosomal RNA and made it possible toobserve the specificity of this probe.

The hybridization of the ribosomal RNAs of a target bacterium wasperformed according to the non-radioactive and semiautomated detectionprocess described in French Patent No. 90 07249 and modified for thedetection of ribosomal RNA by the addition of a destabilizer. Thisdestabilizer (which is a capture probe, starting at nucleotide No. 940and ending at nucleotide No. 970 of the R. tsutsugamushi (referenced 23in the accompanying figure)) and an oligonucleotide-enzyme detectionconjugate (the oligonucleotide corresponding to the probe defined at thebeginning of the present example) are used. The operation was performedin a microtitre plate according to the following procedure.

The ribosomal RNA of the strains was extracted according to the basicprocedure for the extraction of RNA from Gram-positive bacteriadescribed in "Current Protocols in Molecular Biology" 1987, Ausubel FMet al., Wiley interscience, New York. A solution of 1 ng/μl of thecapture oligonucleotide whose 5' end has reacted with the reagentAminolink 2 (Applied Biosystems, Foster city, California) in 3× PBS(0.45 M NaCl, 0.15 M sodium phosphate pH 7.0), is deposited in amicrotitre plate (Nunc 439454). The plate is incubated for 2 h at 37° C.and then washed 3 times with 300 μl of PBST (1× PBS, 0.05% Tween 20(Merck 822184)). The Aminolink 2 reagent makes it possible to add to the5' end of the probe an arm comprising a 6-aminohexyl group. The probethus coupled to a ligand having a polar group (primary amine), andpassively attached to the support, provides an enhanced signal; seeApplication FR 91 09057.

The target consisting of 10 μl of total RNA extract is mixed with 40 μlof PBS-salmon buffer (3× PBS+10 μg/ml of salmon sperm DNA (Sigma D9156)). The whole mixture is added in the well to 50 μl of a solution ofoligonucleotide-peroxidase conjugate, constituting the detection probe,at the concentration of 0.1 ng/μl of oligonucleotide in a PBS-horsebuffer (3× PBS +10% horse serum (BioMerieux 55842)). The plate isincubated for 1 h at 37° C. and then washed 3 times with 300 μl of PBSTbuffer. To each well are added 100 Al of OPD substrate(ortho-phenylenediamine, Cambridge Medical Biotechnology ref/456) in a0.055 M citric acid, 0.1 M sodium monohydrogen phosphate buffer, pH4.93) at a concentration of 4 mg/ml, to which hydrogen peroxide at 30%,diluted 1/1000, is added immediately before use. After reacting for 20min, the enzymatic activity is blocked with 100 μl of 1N sulphuric acidand the reading is carried out on an Axia Microreader apparatus (AXIA :registered trademark) (BioMerieux) at 492 nm.

The target bacteria were especially the following:

30 strains belonging to the order Rickettsiales

20 strains belonging to the genus Rickettsia

7 strains belonging to the species R. tsutsugamushi

The specific combination was adapted on the VIDAS automatic machine(registered trademark--marketed by the company BioMerieux-VITEK). Thewall of the microplate well is replaced here by the SPR (trademark)(Solid Phase Receptacle) which is a conical support made from a materialsold under the name K resin (butadiene-styrene copolymer) and marketedby the company BioMerieux-VITEK (USA). The various reagents aredeposited in a strip with several cuvettes and the various stages takeplace in the SPR which is capable of sucking in and of expelling thereagents and which therefore acts as pipette. The sandwich hybridizationreaction described in the procedure below takes place on the inner wallof the cone.

On the inner surface of the SPR is passively attached the captureoligonucleotide comprising at its 5' end the Aminolink 2 ligand (AppliedBiosystems-ref. 400808) at a concentration of 1 ng/μl in a volume of 315μl of a 4× PBS solution (200 mM sodium phosphate pH 7.0, 600 mM NaCl).After one night at room temperature or two hours at 37° C., the conesare washed twice with a PBS-Tween solution and then dried under vacuum.The strip contains, in cuvettes, the reagents necessary for thedetection, that is to say: 200 μl of a solution at 0.1 ng/μl of theoligonucleotide-alkaline phosphatase detection conjugate, twice 600 μlof PBS-Tween washing solution and a substrate cuvette.

In the first well of the strip 10 μl of extracted RNA are deposited inthe same buffer as for the above microplate procedure.

After incubating the cone for 30 minutes with the target plus detectionprobe mixture, the cone is washed twice with a PBS-Tween solution. 250μl of MUP (4-methyl-umbelliferyl phosphate) substrate in solution in adiethanolamine buffer are sucked into the cone and then released into areading cuvette. The apparatus measures the fluorescent signal,expressed in RFU (relative fluorescence units), of the cuvette.

The results obtained with this system are the same as those obtained ina microplate.

In the same manner, it is possible to verify the specific character ofthe genus or of the species of other nucleotide fragments which are thesubject of the invention.

List and origin of the bacteria whose rDNA sequence corresponding to the16S rRNA is represented in the annex.

1 R.rickettsii (SEQ ID NO: 23) Genbank

14 thai (tick typhus rickettsia) (SEQ ID NO: 24)

10 R.slovaca (M-91 isolate different from R.siberica) (SEQ ID NO: 25)

11 R.japonica (SEQ ID NO: 26)

3 R.conorii (SEQ ID NO: 27)

18 astrakan fever rickettsia (SEQ ID NO: 29)

13 israeli tick typhus rickettsia (SEQ ID NO: 29)

7 R.sibirica (SEQ ID NO: 30)

15 R.parkeri (SEQ ID NO: 31)

16 R.africae (SEQ ID NO: 32)

8 R.massiliae (SEQ ID NO: 33)

17 Bar29 (GS isolate different from R massiliae) (SEQ ID NO: 34)

6 R.rhipicephali (SEQ ID NO: 35)

9 R.montana (SEQ ID NO: 36)

12 R.helvetica (SEQ ID NO: 37)

4 R.australis (SEQ ID NO: 38)

5 R.akari (SEQ ID NO: 39)

31 RSDNAX (EBL bacterium) (SEQ ID NO: 40) Genbank

2 R.bellii (SEQ ID NO: 41)

21 Coccinelle (AB bacterium) (SEQ ID NO: 42) Genbank

22 R.canada (SEQ ID NO: 43)

19 R.prowazekii (SEQ ID NO: 44) Genbank

20 R.typhi (SEQ ID NO: 45) Genbank

23 R. tsutsugamushi (SEQ ID NO: 46)

26 Cowdria ruminantium (CRDNA) (SEQ ID NO: 47) Genbank

25 Ehrlichia chaffeensis (EHRRRNAF) (SEQ ID NO: 48) Genbank

27 Anaplasma marginale (APMRR16SA) (SEQ ID NO: 49) Genbank

28 Wolbachia pipientis (WP16SCP) (SEQ ID NO: 50) Genbank

24 Ehrlichia risticii (EHRRGBSA) (SEQ ID NO: 51) Genbank

30 Rochalimea (Bartonella)quintana ROCRR16SA (SEQ ID NO: 52) Genbank

29 Coxiella burnatti COXRRSA (SEQ ID NO: 53) Genbank

    __________________________________________________________________________    #             SEQUENCE LISTING                                                   - -  - - (1) GENERAL INFORMATION:                                             - -    (iii) NUMBER OF SEQUENCES: 53                                          - -  - - (2) INFORMATION FOR SEQ ID NO:1:                                     - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 33 base - #pairs                                                  (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (iv) ANTI-SENSE: NO                                                   - -     (vi) ORIGINAL SOURCE:                                                          (A) ORGANISM: R. tsutsu - #gamushi                                   - -   (viii) POSITION IN GENOME:                                                       (A) CHROMOSOME/SEGMENT: R. - # rickettsii                                     (B) MAP POSITION: 130-1 - #70                                        - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1:                               - - CGAATTAATG CTGAGTTTGC TTAGTATTAA TTA       - #                  -      #         33                                                                     - -  - - (2) INFORMATION FOR SEQ ID NO:2:                                     - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 21 base - #pairs                                                  (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (iv) ANTI-SENSE: NO                                                   - -     (vi) ORIGINAL SOURCE:                                                          (A) ORGANISM: R. tsutsu - #gamushi                                   - -   (viii) POSITION IN GENOME:                                                       (A) CHROMOSOME/SEGMENT: R. - # rickettsii                                     (B) MAP POSITION: 181-2 - #01                                        - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2:                               - - GTGAGTAACA CGTGGGAATC T           - #                  - #                      - #21                                                                  - -  - - (2) INFORMATION FOR SEQ ID NO:3:                                     - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 27 base - #pairs                                                  (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (iv) ANTI-SENSE: NO                                                   - -     (vi) ORIGINAL SOURCE:                                                          (A) ORGANISM: R. tsutsu - #gamushi                                   - -   (viii) POSITION IN GENOME:                                                       (A) CHROMOSOME/SEGMENT: R. - # rickettsii                                     (B) MAP POSITION: 241-2 - #72                                        - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:3:                               - - TACCGTATGC CCTCTATAAG GAGGAAA          - #                  - #                 27                                                                      - -  - - (2) INFORMATION FOR SEQ ID NO:4:                                     - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base - #pairs                                                  (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (iv) ANTI-SENSE: NO                                                   - -     (vi) ORIGINAL SOURCE:                                                          (A) ORGANISM: R. tsutsu - #gamushi                                   - -   (viii) POSITION IN GENOME:                                                       (A) CHROMOSOME/SEGMENT: R. - # rickettsii                                     (B) MAP POSITION: 284-2 - #98                                        - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:4:                               - - TATCGCTGAT GGATG              - #                  - #                      - #    15                                                                   - -  - - (2) INFORMATION FOR SEQ ID NO:5:                                     - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base - #pairs                                                  (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (iv) ANTI-SENSE: NO                                                   - -     (vi) ORIGINAL SOURCE:                                                          (A) ORGANISM: R. tsutsu - #gamushi                                   - -   (viii) POSITION IN GENOME:                                                       (A) CHROMOSOME/SEGMENT: R. - # rickettsii                                     (B) MAP POSITION: 299-3 - #15                                        - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:5:                               - - AGCCCGCGGC AGATTAG             - #                  - #                      - #   17                                                                   - -  - - (2) INFORMATION FOR SEQ ID NO:6:                                     - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 24 base - #pairs                                                  (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (iv) ANTI-SENSE: NO                                                   - -     (vi) ORIGINAL SOURCE:                                                          (A) ORGANISM: R. tsutsu - #gamushi                                   - -   (viii) POSITION IN GENOME:                                                       (A) CHROMOSOME/SEGMENT: R. - # rickettsii                                     (B) MAP POSITION: 334-3 - #57                                        - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:6:                               - - GCTTACCAAG CCTGTGATCT GTAG          - #                  - #                    24                                                                      - -  - - (2) INFORMATION FOR SEQ ID NO:7:                                     - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 22 base - #pairs                                                  (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (iv) ANTI-SENSE: NO                                                   - -     (vi) ORIGINAL SOURCE:                                                          (A) ORGANISM: R. tsutsu - #gamushi                                   - -   (viii) POSITION IN GENOME:                                                       (A) CHROMOSOME/SEGMENT: R. - # rickettsii                                     (B) MAP POSITION: 460-4 - #81                                        - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:7:                               - - CCAGCAATGC CGCGTGAGTG AT           - #                  - #                     22                                                                      - -  - - (2) INFORMATION FOR SEQ ID NO:8:                                     - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 21 base - #pairs                                                  (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (iv) ANTI-SENSE: NO                                                   - -     (vi) ORIGINAL SOURCE:                                                          (A) ORGANISM: R. tsutsu - #gamushi                                   - -   (viii) POSITION IN GENOME:                                                       (A) CHROMOSOME/SEGMENT: R. - # rickettsii                                     (B) MAP POSITION: 504-5 - #36                                        - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:8:                               - - TCTTTTAGTA GGGATGATAA T           - #                  - #                      - #21                                                                   - -  - - (2) INFORMATION FOR SEQ ID NO:9:                                     - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 21 base - #pairs                                                  (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (iv) ANTI-SENSE: NO                                                   - -     (vi) ORIGINAL SOURCE:                                                          (A) ORGANISM: R. tsutsu - #gamushi                                   - -   (viii) POSITION IN GENOME:                                                       (A) CHROMOSOME/SEGMENT: R. - # rickettsii                                     (B) MAP POSITION: 550-5 - #70                                        - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:9:                               - - GACAGTACCT ACAGAAAAAG C           - #                  - #                      - #21                                                                   - -  - - (2) INFORMATION FOR SEQ ID NO:10:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 25 base - #pairs                                                  (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (iv) ANTI-SENSE: NO                                                   - -     (vi) ORIGINAL SOURCE:                                                          (A) ORGANISM: R. tsutsu - #gamushi                                   - -   (viii) POSITION IN GENOME:                                                       (A) CHROMOSOME/SEGMENT: R. - # rickettsii                                     (B) MAP POSITION: 561-5 - #85                                        - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:10:                              - - CAGAAAAAGC CCCGGCTAAC TCCGT          - #                  - #                   25                                                                      - -  - - (2) INFORMATION FOR SEQ ID NO:11:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 24 base - #pairs                                                  (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (iv) ANTI-SENSE: NO                                                   - -     (vi) ORIGINAL SOURCE:                                                          (A) ORGANISM: R. tsutsu - #gamushi                                   - -   (viii) POSITION IN GENOME:                                                       (A) CHROMOSOME/SEGMENT: R. - # rickettsii                                     (B) MAP POSITION: 661-6 - #84                                        - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:11:                              - - TAATAAGTTA GGAGTGAAAT CCCA          - #                  - #                    24                                                                      - -  - - (2) INFORMATION FOR SEQ ID NO:12:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 30 base - #pairs                                                  (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (iv) ANTI-SENSE: NO                                                   - -     (vi) ORIGINAL SOURCE:                                                          (A) ORGANISM: R. tsutsu - #gamushi                                   - -   (viii) POSITION IN GENOME:                                                       (A) CHROMOSOME/SEGMENT: R. - # rickettsii                                     (B) MAP POSITION: 710-7 - #39                                        - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:12:                              - - AAAACTGTTA GGCTAGAGTA TGGTAGAGGG         - #                  - #               30                                                                      - -  - - (2) INFORMATION FOR SEQ ID NO:13:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 23 base - #pairs                                                  (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (iv) ANTI-SENSE: NO                                                   - -     (vi) ORIGINAL SOURCE:                                                          (A) ORGANISM: R. tsutsu - #gamushi                                   - -   (viii) POSITION IN GENOME:                                                       (A) CHROMOSOME/SEGMENT: R. - # rickettsii                                     (B) MAP POSITION: 903-9 - #29                                        - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:13:                              - - GATATTGGGG GATTTTTCTT TCA           - #                  - #                    23                                                                      - -  - - (2) INFORMATION FOR SEQ ID NO:14:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 21 base - #pairs                                                  (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (iv) ANTI-SENSE: NO                                                   - -     (vi) ORIGINAL SOURCE:                                                          (A) ORGANISM: R. tsutsu - #gamushi                                   - -   (viii) POSITION IN GENOME:                                                       (A) CHROMOSOME/SEGMENT: R. - # rickettsii                                     (B) MAP POSITION: 940-9 - #60                                        - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:14:                              - - TAACGCATTA AGCACTCCGC C           - #                  - #                      - #21                                                                   - -  - - (2) INFORMATION FOR SEQ ID NO:15:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 21 base - #pairs                                                  (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (iv) ANTI-SENSE: NO                                                   - -     (vi) ORIGINAL SOURCE:                                                          (A) ORGANISM: R. tsutsu - #gamushi                                   - -   (viii) POSITION IN GENOME:                                                       (A) CHROMOSOME/SEGMENT: R. - # rickettsii                                     (B) MAP POSITION: 1035- - #1055                                      - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:15:                              - - AATTCGATGA TCCGCGAAAA A           - #                  - #                      - #21                                                                   - -  - - (2) INFORMATION FOR SEQ ID NO:16:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 30 base - #pairs                                                  (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (iv) ANTI-SENSE: NO                                                   - -     (vi) ORIGINAL SOURCE:                                                          (A) ORGANISM: R. tsutsu - #gamushi                                   - -   (viii) POSITION IN GENOME:                                                       (A) CHROMOSOME/SEGMENT: R. - # rickettssii                                    (B) MAP POSITION: 1078- - #1107                                      - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:16:                              - - AGTCGCGAAA AATGGAGACA TTTTTCTTCA         - #                  - #               30                                                                      - -  - - (2) INFORMATION FOR SEQ ID NO:17:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base - #pairs                                                  (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (iv) ANTI-SENSE: NO                                                   - -     (vi) ORIGINAL SOURCE:                                                          (A) ORGANISM: R. tsutsu - #gamushi                                   - -   (viii) POSITION IN GENOME:                                                       (A) CHROMOSOME/SEGMENT: R. - # rickettsii                                     (B) MAP POSITION: 1199- - #1213                                      - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:17:                              - - ATTCTTATTT GCCAG              - #                  - #                      - #    15                                                                   - -  - - (2) INFORMATION FOR SEQ ID NO:18:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 20 base - #pairs                                                  (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (iv) ANTI-SENSE: NO                                                   - -     (vi) ORIGINAL SOURCE:                                                          (A) ORGANISM: R. tsutsu - #gamushi                                   - -   (viii) POSITION IN GENOME:                                                       (A) CHROMOSOME/SEGMENT: R. - # rickettsii                                     (B) MAP POSITION: 1330- - #1350                                      - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:18:                              - - CTACAGAGTG ATGCGATACG            - #                  - #                      - # 20                                                                   - -  - - (2) INFORMATION FOR SEQ ID NO:19:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 26 base - #pairs                                                  (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (iv) ANTI-SENSE: NO                                                   - -     (vi) ORIGINAL SOURCE:                                                          (A) ORGANISM: R. tsutsu - #gamushi                                   - -   (viii) POSITION IN GENOME:                                                       (A) CHROMOSOME/SEGMENT: R. - # rickettsii                                     (B) MAP POSITION: 1361- - #1387                                      - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:19:                              - - AGCTAATCAT TAAAAGGTAT CTCAGT          - #                  - #                  26                                                                      - -  - - (2) INFORMATION FOR SEQ ID NO:20:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 35 base - #pairs                                                  (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (iv) ANTI-SENSE: NO                                                   - -     (vi) ORIGINAL SOURCE:                                                          (A) ORGANISM: R. tsutsu - #gamushi                                   - -   (viii) POSITION IN GENOME:                                                       (A) CHROMOSOME/SEGMENT: R. - # rickettsii                                     (B) MAP POSITION: 1429- - #1463                                      - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:20:                              - - CGCTAGTAAT CGCGGATCAG CATGCCGCGG TGAAT       - #                  -     #       35                                                                      - -  - - (2) INFORMATION FOR SEQ ID NO:21:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 20 base - #pairs                                                  (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (iv) ANTI-SENSE: NO                                                   - -     (vi) ORIGINAL SOURCE:                                                          (A) ORGANISM: R. tsutsu - #gamushi                                   - -   (viii) POSITION IN GENOME:                                                       (A) CHROMOSOME/SEGMENT: R. - # rickettsii                                     (B) MAP POSITION: 1501- - #1520                                      - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:21:                              - - TGGGAGTCAG TGGTACCTGA            - #                  - #                      - # 20                                                                   - -  - - (2) INFORMATION FOR SEQ ID NO:22:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 22 base - #pairs                                                  (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (iv) ANTI-SENSE: NO                                                   - -     (vi) ORIGINAL SOURCE:                                                          (A) ORGANISM: R. tsutsu - #gamushi                                   - -   (viii) POSITION IN GENOME:                                                       (A) CHROMOSOME/SEGMENT: R. - # rickettsii                                     (B) MAP POSITION: 1555- - #1576                                      - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:22:                              - - CACGGTAGAA CTGGTGACTG GG           - #                  - #                     22                                                                      - -  - - (2) INFORMATION FOR SEQ ID NO:23:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 1440 base - #pairs                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:23:                              - - CCTGGCTCAG AACGAACGCT ATCGGTATGC TTAACACATG CAAGTCGAAC GG -             #ACTAATTG     60                                                                 - - GGGCTTGCTC CAATTAGTTA GTGGCAGACG GGTGAGTAAC ACGTGGGAAT CT -            #ACCCATCA    120                                                                 - - GTACGGAATA ACTTTTAGAA ATAAAAGCTA ATACCGTATA TTCTCTGCGG AG -            #GAAAGATT    180                                                                 - - TATCGCTGAT GGATGAGCCC GCGTCAGATT AGGTAGTTGG TGAGGTAATG GC -            #TCACCAAG    240                                                                 - - CCGACGATCT GTAGCTGGTC TGAGAGGATG ATCAGCCACA CTGGGACTGA GA -            #CACGGCCC    300                                                                 - - AGACTCCTAC GGGAGGCAGC AGTGGGGAAT ATTGGACAAT GGGCGAAAGC CT -            #GATCCAGC    360                                                                 - - AATACCGAGT GAGTGATGAA GGCCTTAGGG TTGTAAAGCT CTTTTAGCAA GG -            #AAGATAAT    420                                                                 - - GACGTTACTT GCAGAAAAAG CCCCGGCTAA CTCCGTGCCA GCAGCCGCGG TA -            #AGACGGAG    480                                                                 - - GGGGCTAGCG TTGTTCGGAA TTACTGGGCG TAAAGAGTGC GTAGGCGGTT TA -            #GTAAGTTG    540                                                                 - - GAAGTGAAAG CCCGGGGCTT AACCTCGGAA TTGCTTTCAA AACTACTAAT CT -            #AGAGTGTA    600                                                                 - - GTAGGGGATG ATGGAATTCC TAGTGTAGAG GTGAAATTCT TAGATATTAG GA -            #GGAACACC    660                                                                 - - GGTGGCGAAG GCGGTCATCT GGGCTACCAC TGACGCTGAT GCACGAAAGC GT -            #GGGGAGCA    720                                                                 - - AACAGGATTA GATACCCTGG TAGTCCACGC CGTAAACGAT GAGTGCTAGA TA -            #TCGGAAGA    780                                                                 - - TTCTCTTTCG GTTTCGCAGC TAACGCATTA AGCACTCCGC CTGGGGAGTA CG -            #GTCGCAAG    840                                                                 - - ATTAAAACTC AAAGGAATTG ACGGGGGCTC GCACAAGCGG TGGAGCATGC GG -            #TTTAATTC    900                                                                 - - GATGTTACGC GAAAAACCTT ACCAACCCTT GACATGGTGG TTGCGGATCG CA -            #GAGATGCT    960                                                                 - - TTTCTTCAGC TCGGCTGGAC CACACACAGG TGTTGCATGG CTGTCGTCAG CT -            #CGTGTCGT   1020                                                                 - - GAGATGTTGG GTTAAGTCCC GCAACGAGCG CAACCCTCAT TCTTATTTGC CA -            #GCGGGTAA   1080                                                                 - - TGCCGGGAAC TATAAGAAAA CTGCCGGTGA TAAGCCGGAG GAAGGTGGGG AC -            #GACGTCAA   1140                                                                 - - GTCATCATGG CCCTTACGGG TTGGGCTACA CGCGTGCTAC AATGGTGTTT AC -            #AGAGGGAA   1200                                                                 - - GCAAGACGGC GACGTGGAGC AAATCCCTAA AAGACATCTC AGTTCGGATT GT -            #TCTCTGCA   1260                                                                 - - ACTCGAGAGC ATGAAGTTGG AATCGCTAGT AATCGCGGAT CAGCATGCCG CG -            #GTGAATAC   1320                                                                 - - GTTCTCGGGC CTTGTACACA CTGCCCGTCA CGCCATGGGA GTTAGTTTTA CC -            #TGAAGGTG   1380                                                                 - - GTGAGCTAAC GCAAGAGGCA GCCAACCACG GTAAAATTAG CGACTGGGGT GA -            #AGTCGTAA   1440                                                                 - -  - - (2) INFORMATION FOR SEQ ID NO:24:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 1438 base - #pairs                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:24:                              - - TGGCTCAGAA CGAACGCTAT CGGTATGCTT AACACATGCA AGTCGAACGG AC -            #TAATTGGG     60                                                                 - - GCTTGCTCCA ATTAGTTAGT GGCAGACGGG TGAGTAACAC GTGGGAATCT AC -            #CCATCAGT    120                                                                 - - ACGGAATAAC TTTTAGAAAT AAAAGCTAAT ACCGTATATT CTCTGCGGAG GA -            #AAGATTTA    180                                                                 - - TCGCTGATGG ATGAGCCCGC GTCAGATTAG GTAGTTGGTG AGGTAATGGC TC -            #ACCAAGCC    240                                                                 - - GACGATCTGT AGCTGGTCTG AGAGGATGAT CAGCCACACT GGGACTGAGA CA -            #CGGCCCAG    300                                                                 - - ACTCCTACGG GAGGCAGCAG TGGGGAATAT TGGACAATGG GCGAAAGCCT GA -            #TCCAGCAA    360                                                                 - - TACCGAGTGA GTGATGAAGG CCTTAGGGTT GTAAAGCTCT TTTAGCAAGG AA -            #GATAATGA    420                                                                 - - CGTTACTTGC AGAAAAAGCC CCGGCTAACT CCGTGCCAGC AGCCGCGGTA AG -            #ACGGAGGG    480                                                                 - - GGCTAGCGTT GTTCGGAATT ACTGGGCGTA AAGAGTGCGT AGGCGGTTTA GT -            #AAGTTGGA    540                                                                 - - AGTGAAAGCC CGGGGCTTAA CCTCGGAATT GCTTTCAAAA CTACTAGTCT AG -            #AGTGTAGT    600                                                                 - - AGGGGATGAT GGAATTCCTA GTGTAGAGGT GAAATTCTTA GATATTAGGA GG -            #AACACCAG    660                                                                 - - TGGCGAAGGC GGTCATCTGG GCTACAACTG ACGCTGATGC ACGAAAGCGT GG -            #GGAGCAAA    720                                                                 - - CAGGATTAGA TACCCTGGTA GTCCACGCCG TAAACGATGA GTGCTAGATA TC -            #GGAAGATT    780                                                                 - - CTCTTTCGGT TTCGCAGCTA ACGCATTAAG CACTCCGCCT GGGGAGTACG GT -            #CGCAAGAT    840                                                                 - - TAAAACTCAA AGGAATTGAC GGGGGCTCGC ACAAGCGGTG GAGCATGCGG TT -            #TAATTCGA    900                                                                 - - TGTTACGCGA AAAACCTTAC CAACCCTTGA CATGGTGGTC GCGGATCGCA GA -            #GATGCTTT    960                                                                 - - TCTTCAGCTC GGCTGGACCA CACACAGGTG TTGCATGGCT GTCGTCAGCT CG -            #TGTCGTGA   1020                                                                 - - GATGTTGGGT TAAGTCCCGC AACGAGCGCA ACCCTCATTC TTATTTGCCA GC -            #GGGTAATG   1080                                                                 - - CCGGGAACTA TAAGAAAACT GCCGGTGATA AGCCGGAGGA AGGTGGGGAC GA -            #CGTCAAGT   1140                                                                 - - CATCATGGCC CTTACGGGTT GGGCTACACG CGTGCTACAA TGGTGTTTAC AG -            #AGGGAAGC   1200                                                                 - - AAGACGGCGA CGTGGAGCAA ATCCCTAAAA GACATCTCAG TTCGGATTGT TC -            #TCTGCAAC   1260                                                                 - - TCGAGAGCAT GAAGTTGGAA TCGCTAGTAA TCGCGGATCA GCATGCCGCG GT -            #GAATACGT   1320                                                                 - - TCTCGGGCCT TGTACACACT GCCCGTCACG CCATGGGAGT TAGTTTTACC TG -            #AAGGTGGT   1380                                                                 - - GAGCTAACGC AAGAGGCAGC CAACCACGGT AAAATTAGCG ACTGGGGTGA AG -            #TCGTAA     1438                                                                 - -  - - (2) INFORMATION FOR SEQ ID NO:25:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 1432 base - #pairs                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:25:                              - - AGAACGAACG CTATCGGTAT GCTTAACACA TGCAAGTCGA ACGGACTAAT TG -            #GGGCTTGC     60                                                                 - - TCCAATTAGT TAGTGGCAGA CGGGTGAGTA ACACGTGGGA ATCTACCCAT CA -            #GTACGGAA    120                                                                 - - TAACTTTTAG AAATAAAAGC TAATACCGTA TATTCTCTGC GGAGGAAAGA TT -            #TATCGCTG    180                                                                 - - ATGGATGAGC CCGCGTCAGA TTAGGTAGTT GGTGAGGTAA TGGCTCACCA AG -            #CCGACGAT    240                                                                 - - CTGTAGCTGG TCTGAGAGGA TGATCAGCCA CACTGGGACT GAGACACGGC CC -            #AGACTCCT    300                                                                 - - ACGGGAGGCA GCAGTGGGGA ATATTGGACA ATGGGCGAAA GCCTGATCCA GC -            #AATACCGA    360                                                                 - - GTGAGTGATG AAGGCCTTAG GGTTGTAAAG CTCTTTTAGC AAGGAAGATA AT -            #GACGTTAC    420                                                                 - - TTGCAGAAAA AGCCCCGGCT AACTCCGTGC CAGCAGCCGC GGTAAGACGG AG -            #GGGGCTAG    480                                                                 - - CGTTGTTCGG AATTACTGGG CGTAAAGAGT GCGTAGGCGG TTTAGTAAGT TG -            #GAAGTGAA    540                                                                 - - AGCCCGGGGC TTAACCTCGG AATTGCTTTC AAAACTACTA ATCTAGAGTG TA -            #GTAGGGGA    600                                                                 - - TGATGGAATT CCTAGTGTAG AGGTGAAATT CTTAGATATT AGGAGGAACA CC -            #GGTGGCGA    660                                                                 - - AGGCGGTCAT CTGGGCTACA ACTGACGCTG ATGCACGAAA GCGTGGGGAG CA -            #AACAGGAT    720                                                                 - - TAGATACCCT GGTAGTCCAC GCCGTAAACG ATGAGTGCTA GATATCGGAA GA -            #TTCTCTTT    780                                                                 - - CGGTTTCGTA GCTAACGCAT TAAGCACTCC GCCTGGGGAG TACGGTCGCA AG -            #ATTAAAAC    840                                                                 - - TCAAAGGAAT TGACGGGGGC TCGCACAAGC GGTGGAGCAT GCGGTTTAAT TC -            #GATGTTAC    900                                                                 - - GCGAAAAACC TTACCAACCC TTGACATGGT GGTCGCGGAT CGCAGAGATG CT -            #TTTCTTCA    960                                                                 - - GCTCGGCTGG ACCACACACA GGTGTTGCAT GGCTGTCGTC AGCTCGTGTC GT -            #GAGATGTT   1020                                                                 - - GGGTTAAGTC CCGCAACGAG CGCAACCCTC ATTCTTATTT GCCAGCGGGT AA -            #TGCCGGGA   1080                                                                 - - ACTATAAGAA AACTGCCGGT GATAAGCCGG AGGAAGGTGG GGACGACGTC AA -            #GTCATCAT   1140                                                                 - - GGCCCTTACG GGTTGGGCTA CACGCGTGCT ACAATGGTGT TTACAGAGGG AA -            #GCAAGACG   1200                                                                 - - GCGACGTGGA GCAAATCCCT AAAAGACATC TCAGTTCGGA TTGTTCTCTG CA -            #ACTCGAGA   1260                                                                 - - GCATGAAGTT GGAATCGCTA GTAATCGCGG ATCAGCATGC CGCGGTGAAT AC -            #GTTCTCGG   1320                                                                 - - GCCTTGTACA CACTGCCCGT CACGCCATGG GAGTTAGTTT TACCTGAAGG TG -            #GTGAGCTA   1380                                                                 - - ACGCAAGAGG CAGCCAACCA CGGTAAAATT AGCGACTGGG GTGAAGTCGT AA - #               1432                                                                       - -  - - (2) INFORMATION FOR SEQ ID NO:26:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 1440 base - #pairs                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:26:                              - - CCTGGCTCAG AACGAACGCT ATCGGTATGC TTAACACATG CAAGTCGAAC GG -             #ACTAATTG     60                                                                 - - GGGCTTGCTC CAATTAGTTA GTGGCAGACG GGTGAGTAAC ACGTGGGAAT CT -            #ACCCATCA    120                                                                 - - GTACGGAATA ACTTTTAGAA ATAAAAGCTA ATACCGTATA TTCTCTGCGG AG -            #GAAAGATT    180                                                                 - - TATTGCTGAT GGATGAGCCC GCGTCAGATT AGGTAGTTGG TGAGGTAATG GC -            #TCACCAAG    240                                                                 - - CCGACGATCT GTAGCTGGTC TGAGAGGATG ATCAGCCACA CTGGGACTGA GA -            #CACGGCCC    300                                                                 - - AGACTCCTAC GGGAGGCAGC AGTGGGGAAT ATTGGACAAT GGGCGAAAGC CT -            #GATCCAGC    360                                                                 - - AATACCGAGT GAGTGATGAA GGCCTTAGGG TTGTAAAGCT CTTTTAGCAA GG -            #AAGATAAT    420                                                                 - - GACGTTACTT GCAGAAAAAG CCCCGGCTAA CTCCGTGCCA GCAGCCGCGG TA -            #AGACGGAG    480                                                                 - - GGGGCTAGCG TTGTTCGGAA TTACTGGGCG TAAAGAGTGC GTAGGCGGTT TA -            #GTAAGTTG    540                                                                 - - GAAGTGAAAG CCCGGGGCTT AACCTCGGAA TTGCTTTCAA AACTACTAAT CT -            #AGAGTGTA    600                                                                 - - GTAGGGGATG ATGGAATTCC TAGTGTAGAG GTGAAATTCT TAGATATTAG GA -            #GGAACACC    660                                                                 - - GGTGGCGAAG GCGATCATCT GGGCTACAAC TGACGCTGAT GCACGAAAGC GT -            #GGGGAGCA    720                                                                 - - AACAGGATTA GATACCCTGG TAGTCCACGC CGTAAACGAT GAGTGCTAGA TA -            #TCGGAAGA    780                                                                 - - TTCTCTTTCG GTTTCGCAGC TAACGCATTA AGCACTCCGC CTGGGGAGTA CG -            #GTCGCAAG    840                                                                 - - ATTAAAACTC AAAGGAATTG ACGGGGGCTC GCACAAGCGG TGGAGCATGC GG -            #TTTAATTC    900                                                                 - - GATGTTACGC GAAAAACCTT ACCAACCCTT GACATGGTGG TCGCGGATCG CA -            #GAGATGCT    960                                                                 - - TTTCTTCAGC TCGGCTGGAT CACACACAGG TGTTGCATGG CTGTCGTCAG CT -            #CGTGTCGT   1020                                                                 - - GAGATGTTGG GTTAAGTCCC GCAACGAGCG CAACCCTCAT TCTTATTTGC CA -            #GCGGGTAA   1080                                                                 - - TGCCGGGAAC TATAAGAAAA CTGCCGGTGA TAAGCCGGAG GAAGGTGGGG AC -            #GACGTCAA   1140                                                                 - - GTCATCATGG CCCTTACGGG TTGGGCTACA CGCGTGCTAC AATGGTGTTT AC -            #AGAGGGAA   1200                                                                 - - GCAAGACGGC GACGTGGAGC AAATCCCTAA AAGACATCTC AGTTCGGATT GT -            #TCTCTGCA   1260                                                                 - - ACTCGAGAGC ATGAAGTTGG AATCGCTAGT AATCGCGGAT CAGCATGCCG CG -            #GTGAATAC   1320                                                                 - - GTTCTCGGGC CTTGTACACA CTGCCCGTCA CGCCATGGGA GTTGGTTTTA CC -            #TGAAGGTG   1380                                                                 - - GTGAGCTAAC GCAAGAGGCA GCCAACCACG GTAAAATTAG CGACTGGGGT GA -            #AGTCGTAA   1440                                                                 - -  - - (2) INFORMATION FOR SEQ ID NO:27:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 1427 base - #pairs                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:27:                              - - GAACGCTATC GGTATGCTTA ACACATGCAA GTCGAACGGA CTAATTGGGG CT -            #TGCTCCAG     60                                                                 - - TTAGTTAGTG GCAGACGGGT GAGTAACACG TGGGAATCTA CCCATTAGTA CG -            #GAATAACT    120                                                                 - - TTTAGAAATA AAAGCTAATA CCGTATATTC TCTGCGGAGG AAAGATTTAT CG -            #CTGATGGA    180                                                                 - - TGAGCCCGCG TCAGATTAGG TAGTTGGTGA GGTAATGGCT CACCAAGCCG AC -            #GATCTGTA    240                                                                 - - GCTGGTCTGA GAGGATGATC AGCCACACTG GGACTGAGAC ACGGCCCAGA CT -            #CCTACGGG    300                                                                 - - AGGCAGCAGT GGGGAATATT GGACAATGGG CGAAAGCCTG ATCCAGCAAT AC -            #CGAGTGAG    360                                                                 - - TGATGAAGGC CTTAGGGTTG TAAAGCTCTT TTAGCAAGGA AGATAATGAC GT -            #TACTTGCA    420                                                                 - - GAAAAAGCCC CGGCTAACTC CGTGCCAGCA GCCGCGGTAA GACGGAGGGG GC -            #TAGCGTTG    480                                                                 - - TTCGGAATTA CTGGGCGTAA AGAGTGCGTA GGCGGTTTAG TAAGTTGGAA GT -            #GAAAGCCC    540                                                                 - - GGGGCTTAAC CTCGGAATTG CTTTCAAAAC TACTAATCTA GAGTGTAGTA GG -            #GGATGATG    600                                                                 - - GAATTCCTAG TGTAGAGGTG AAATTCTTAG ATATTAGGAG GAACACCGGT GG -            #CGAAGGCG    660                                                                 - - GTCATCTGGG CTACAACTGA CGCTGATGCA CGAAAGCGTG GGGAGCAAAC AG -            #GATTAGAT    720                                                                 - - ACCCTGGTAG TCCACGCCGT AAACGATGAG TGCTAGATAT CGGAAGATTC TC -            #TTTCGGTT    780                                                                 - - TCGCAGCTAA CGCATTAAGC ACTCCGCCTG GGGAGTACGG TCGCAAGATT AA -            #AACTCAAA    840                                                                 - - GGAATTGACG GGGGCTCGCA CAAGCGGTGG AGCATGCGGT TTAATTCGAT GT -            #TACGCGAA    900                                                                 - - AAACCTTACC AACCCTTGAC ATGGTGGTCG CGGATCGCAG AGATGCTTTT CT -            #TCAGCTCG    960                                                                 - - GCTGGACCAC ACACAGGTGT TGCATGGCTG TCGTCAGCTC GTGTCGTGAG AT -            #GTTGGGTT   1020                                                                 - - AAGTCCCGCA ACGAGCGCAA CCCTCATTCT TATTTGCCAG CGGGTAATGC CG -            #GGAACTAT   1080                                                                 - - AAGAAAACTG CCGGTGATAA GCCGGAGGAA GGTGGGGACG ACGTCAAGTC AT -            #CATGGCCC   1140                                                                 - - TTACGGGTTG GGCTACACGC GTGCTACAAT GGTGTTTACA GAGGGAAGCA AG -            #ACGGCGAC   1200                                                                 - - GTGGAGCAAA TCCCTAAAAG ACATCTCAGT TCGGATTGTT CTCTGCAACT CG -            #AGAGCATG   1260                                                                 - - AAGTTGGAAT CGCTAGTAAT CGCGGATCAG CATGCCGCGG TGAATACGTT CT -            #CGGGCCTT   1320                                                                 - - GTACACACTG CCCGTCACGC CATGGGAGTT AGTTTTACCT GAAGGTGGTG AG -            #CTAACGCA   1380                                                                 - - AGAGGCAGCC AACCACGGTA AAATTAGCGA CTGGGGTGAA GTCGTAA   - #                  1427                                                                        - -  - - (2) INFORMATION FOR SEQ ID NO:28:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 1440 base - #pairs                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:28:                              - - CCTGGCTCAG AACGAACGCT ATCGGTATGC TTAACACATG CAAGTCGAAC GG -             #ACTAATTG     60                                                                 - - GGGCTTGCTC CAGTTAGTTA GTGGCAGACG GGTGAGTAAC ACGTGGGAAT CT -            #ACCCATTA    120                                                                 - - GTACGGAATA ACTTTTAGAA ATAAAAGCTA ATACCGTATA TTCTCTGCGG AG -            #GAAAGATT    180                                                                 - - TATCGCTGAT GGATGAGCCC GCGTCAGATT AGGTAGTTGG TGAGGTAATG GC -            #TCACCAAG    240                                                                 - - CCGACGATCT GTAGCTGGTC TGAGAGGATG ATCAGCCACA CTGGGACTGA GA -            #CACGGCCC    300                                                                 - - AGACTCCTAC GGGAGGCAGC AGTGGGGAAT ATTGGACAAT GGGCGAAAGC CT -            #GATCCAGC    360                                                                 - - AATACCGAGT GAGTGATGAA GGCCTTAGGG TTGTAAAGCT CTTTTAGCAA GG -            #AAGATAAT    420                                                                 - - GACGTTACTT GCAGAAAAAG CCCCGGCTAA CTCCGTGCCA GCAGCCGCGG TA -            #AGACGGAG    480                                                                 - - GGGGCTAGCG TTGTTCGGAA TTACTGGGCG TAAAGAGTGC GTAGGCGGTT TA -            #GTAAGTTG    540                                                                 - - GAAGTGAAAG CCCGGGGCTT AACCTCGGAA TTGCTTTCAA AACTACTAAT CT -            #AGAGTGTA    600                                                                 - - GTAGGGGATG ATGGAATTCC TAGTGTAGAG GTGAAATTCT TAGATATTAG GA -            #GGAACACC    660                                                                 - - GGTGGCGAAG GCGGTCATCT GGGCTACAAC TGACGCTGAT GCACGAAAGC GT -            #GGGGAGCA    720                                                                 - - AACAGGATTA GATACCCTGG TAGTCCACGC CGTAAACGAT GAGTGCTAGA TA -            #TCGGAAGA    780                                                                 - - GTCTCTTTCG GTTTCGCAGC TAACGCATTA AGCACTCCGC CTGGGGAGTA CG -            #GTCGCAAG    840                                                                 - - ATTAAAACTC AAAGGAATTG ACGGGGGCTC GCACAAGCGG TGGAGCATGC GG -            #TTTAATTC    900                                                                 - - GATGTTACGC GAAAAACCTT ACCAACCCTT GACATGGTGG TCGCGGATCG CA -            #GAGATGCT    960                                                                 - - TTTCTTCAGC TCGGCTGGAC CACACACAGG TGTTGCATGG CTGTCGTCAG CT -            #CGTGTCGT   1020                                                                 - - GAGATGTTGG GTTAAGTCCC GCAACGAGCG CAACCCTCAT TCTTATTTGC CA -            #GCGGGTAA   1080                                                                 - - TGCCGGGAAC TATAAGAAAA CTGCCGGTGA TAAGCCGGAG GAAGGTGGGG AC -            #GACGTCAA   1140                                                                 - - GTCATCATGG CCCTTACGGG TTGGGCTACA CGCGTGCTAC AATGGTGTTT AC -            #AGAGGGAA   1200                                                                 - - GCAAGACGGC GACGTGGAGC AAATCCCTAA AAGACATCTC AGTTCGGATT GT -            #TCTCTGCA   1260                                                                 - - ACTCGAGAGC ATGAAGTTGG AATCGCTAGT AATCGCGGAT CAGCATGCCG CG -            #GTGAATAC   1320                                                                 - - GTTCTCGGGC CTTGTACACA CTGCCCGTCA CGCCATGGGA GTTAGTTTTA CC -            #TGAAGGTG   1380                                                                 - - GTGAGCTAAC GCAAGAGGCA GCCAACCACG GTAAAATTAG CGACTGGGGT GA -            #AGTCGTAA   1440                                                                 - -  - - (2) INFORMATION FOR SEQ ID NO:29:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 1440 base - #pairs                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:29:                              - - CCTGGCTCAG AACGAACGCT ATCGGTATGC TTAACACATG CAAGTCGAAC GG -            #ACTAATTG     60                                                                 - - GGGCTTGCTC CAGTTAGTTA GTGGCAGACG GGTGAGTAAC ACGTGGGAAT CT -            #ACCCATTA    120                                                                 - - GTACGGAATA ACTTTTAGAA ATAAAAGCTA ATACCGTATA TTCTCTGTGG AG -            #GAAAGATT    180                                                                 - - TATCGCTGAT GGATGAGCCC GCGTCAGATT AGGTAGTTGG TGAGGTAATG GC -            #TCACCAAG    240                                                                 - - CCGACGATCT GTAGCTGGTC TGAGAGGATG ATCAGCCACA CTGGGACTGA GA -            #CACGGCCC    300                                                                 - - AGACTCCTAC GGGAGGCAGC AGTGGGGAAT ATTGGACAAT GGGCGAAAGC CT -            #GATCCAGC    360                                                                 - - AATACCGAGT GAGTGATGAA GGCCTTAGGG TTGTAAAGCT CTTTTAGCAA GG -            #AAGATAAT    420                                                                 - - GACGTTACTT GCAGAAAAAG CCCCGGCTAA CTCCGTGCCA GCAGCCGCGG TA -            #AGACGGAG    480                                                                 - - GGGGCTAGCG TTGTTCGGAA TTACTGGGCG TAAAGAGTGC GTAGGCGGTT TA -            #GTAAGTTG    540                                                                 - - GAAGTGAAAG CCCGGGGCTT AACCTCGGAA TTGCTTTCAA AACTACTAAT CT -            #AGAGTGTA    600                                                                 - - GTAGGGGATG ATGGAATTCC TAGTGTAGAG GTGAAATTCT TAGATATTAG GA -            #GGAACACC    660                                                                 - - GGTGGCGAAG GCGGTCATCT GGGCTACAAC TGACGCTGAT GCACGAAAGC GT -            #GGGGAGCA    720                                                                 - - AACAGGATTA GATACCCTGG TAGTCCACGC CGTAAACGAT GAGTGCTAGA TA -            #TCGGAAGA    780                                                                 - - TTTTCTTTCG GTTTCGCAGC TAACGCATTA AGCACTCCGC CTGGGGAGTA CG -            #GTCGCAAG    840                                                                 - - ATTAAAACTC AAAGGAATTG ACGGGGGCTC GCACAAGCGG TGGAGCATGC GG -            #TTTAATTC    900                                                                 - - GATGTTACGC GAAAAACCTT ACCAACCCTT GACATGGTGG TCGCGGATCG CA -            #GAGATGCT    960                                                                 - - TTTCTTCAGC TCGGCTGGAC CACACACAGG TGTTGCATGG CTGTCGTCAG CT -            #CGTGTCGT   1020                                                                 - - GAGATGTTGG GTTAAGTCCC GCAACGAGCG CAACCCTCAT TCTTATTTGC CA -            #GCGGGTAA   1080                                                                 - - TGCCGGGAAC TATAAGAAAA CTGCCGGTGA TAAGCCGGAG GAAGGTGGGG AC -            #GACGTCAA   1140                                                                 - - GTCATCATGG CCCTTACGGG TTGGGCTACA CGCGTGCTAC AATGGTGTTT AC -            #AGAGGGAA   1200                                                                 - - GCAAGACGGC GACGTGGAGC AAATCCCTAA AAGACATCTC AGTTCGGATT GT -            #TCTCTGCA   1260                                                                 - - ACTCGAGAGC ATGAAGTTGG AATCGCTAGT AATCGCGGAT CAGCATGCCG CG -            #GTGAATAC   1320                                                                 - - GTTCTCGGGC CTTGTACACA CTGCCCGTCA CGCCATGGGA GTTAGTTTTA CC -            #TGAAGGTG   1380                                                                 - - GTGAGCTAAC GCAAGAGGCA GCCAACCACG GTAAAATTAG CGACTGGGGT GA -            #AGTCGTAA   1440                                                                 - -  - - (2) INFORMATION FOR SEQ ID NO:30:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 1442 base - #pairs                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:30:                              - - CCTGGCTCAG AACGAACGCT ATCGGTATGC TTAACACATG CAAGTCGAAC GG -            #ACTAATTT     60                                                                 - - GGGGCTTGCT CCAATTTAGT TAGTGGCAGA CGGGTGAGTA ACACGTGGGA AT -            #CTACCCAT    120                                                                 - - TAGTACGGAA TAACTTTTAG AAATAAAAGC TAATACCGTA TATTCTCTGC GG -            #AGGAAAGA    180                                                                 - - TTTATCGCTG ATGGATGAGC CCGCGTCAGA TTAGGTAGTT GGTGAGGTAA TG -            #GCTCACCA    240                                                                 - - AGCCGACGAT CTGTAGCTGG TCTGAGAGGA TGATCAGCCA CACTGGGACT GA -            #GACACGGC    300                                                                 - - CCAGACTCCT ACGGGAGGCA GCAGTGGGGA ATATTGGACA ATGGGCGAAA GC -            #CTGATCCA    360                                                                 - - GCAATACCGA GTGAGTGATG AAGGCCTTAG GGTTGTAAAG CTCTTTTAGC AA -            #GGAAGATA    420                                                                 - - ATGACGTTAC TTGCAGAAAA AGCCCCGGCT AACTCCGTGC CAGCAGCCGC GG -            #TAAGACGG    480                                                                 - - AGGGGGCTAG CGTTGTTCGG AATTACTGGG CGTAAAGAGT GCGTAGGCGG TT -            #TAGTAAGT    540                                                                 - - TGGGAGTGAA AGCCCGGGGC TTAACCTCGG AATTGCTTTC AAAACTACTA AT -            #CTAGAGTG    600                                                                 - - TAGTAGGGGA TGATGGAATT CCTAGTGTAG AGGTGAAATT CTTAGATATT AG -            #GAGGAACA    660                                                                 - - CCGGTGGCGA AGGCGGTCAT CTGGGCTACA ACTGACGCTG ATGCACGAAA GC -            #GTGGGGAG    720                                                                 - - CAAACAGGAT TAGATACCCT GGTAGTCCAC GCCGTAAACG ATGAGTGCTA GA -            #TATCGGAA    780                                                                 - - GATTCTCTTT CGGTTTCGCA GCTAACGCAT TAAGCACTCC GCCTGGGGAG TA -            #CGGTCGCA    840                                                                 - - AGATTAAAAC TCAAAGGAAT TGACGGGGGC TCGCACAAGC GGTGGAGCAT GC -            #GGTTTAAT    900                                                                 - - TCGATGTTAC GCGAAAAACC TTACCAACCC TTGACATGGT GGTCGCGGAT CG -            #CAGAGATG    960                                                                 - - CTTTTCTTCA GCTCGGCTGG ACCACACACA GGTGTTGCAT GGCTGTCGTC AG -            #CTCGTGTC   1020                                                                 - - GTGAGATGTT GGGTTAAGTC CCGCAACGAG CGCAACCCTC ATTCTTATTT GC -            #CAGCGGGT   1080                                                                 - - AATGCCGGGA ACTATAAGAA AACTGCCGGT GATAAGCCGG AGGAAGGTGG GG -            #ACGACGTC   1140                                                                 - - AAGTCATCAT GGCCCTTACG GGTTGGGCTA CACGCGTGCT ACAATGGTGT TT -            #ACAGAGGG   1200                                                                 - - AAGCAAGACG GCGACGTGGA GCAAATCCCT AAAAGACATC TCAGTTCGGA TT -            #GTTCTCTG   1260                                                                 - - CAACTCGAGA GCATGAAGTT GGAATCGCTA GTAATCGCGG ATCAGCATGC CG -            #CGGTGAAT   1320                                                                 - - ACGTTCTCGG GCCTTGTACA CACTGCCCGT CACGCCATGG GAGTTAGTTT TA -            #CCTGAAGG   1380                                                                 - - TGGTGAGCTA ACGCAAGAGG CAGCCAACCA CGGTAAAATT AGCGACTGGG GT -            #GAAGTCGT   1440                                                                 - - AA                  - #                  - #                  - #                1442                                                                  - -  - - (2) INFORMATION FOR SEQ ID NO:31:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 1439 base - #pairs                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:31:                              - - TGGCTCAGAA CGAACGCTAT CGGTATGCTT AACACATGCA AGTCGAACGG AC -             #TAATTTGG     60                                                                 - - GGCTTGCTCC AATTAGTTAG TGGCAGACGG GTGAGTAACA CGTGGGAATC TA -            #CCCATTAG    120                                                                 - - TACGGAATAA CTTTTAGAAA TAAAAGCTAA TACCGTATAT TCTCTGCGGA GG -            #AAAGATTT    180                                                                 - - ATCGCTGATG GATGAGCCCG CGTCAGATTA GGTAGTTGGT GAGGTAATAG CT -            #CACCAAGC    240                                                                 - - CGACGATCTG TAGCTGGTCT GAGAGGATGA TCAGCCACAC TGGGACTGAG AC -            #ACGGCCCA    300                                                                 - - GACTCCTACG GGAGGCAGCA GTGGGGAATA TTGGACAATG GGCGAAAGCC TG -            #ATCCAGCA    360                                                                 - - ATACCGAGTG AGTGATGAAG GCCTTAGGGT TGTAAAGCTC TTTTAGCAAG GA -            #AGATAATG    420                                                                 - - ACGTTACTTG CAGAAAAAGC CCCGGCTAAC TCCGTGCCAG CAGCCGCGGT AA -            #GACGGAGG    480                                                                 - - GGGCTAGCGT TGTTCGGAAT TACTGGGCGT AAAGAGTGCG TAGGCGGTTT AG -            #TAAGTTGG    540                                                                 - - AAGTGAAAGC CCGGGGCTTA ACCTCGGAAT TGCTTTCAAA ACTACTAATC TA -            #GAGTGTAG    600                                                                 - - TAGGGGATGA TGGAATTCCT AGTGTAGAGG TGAAATTCTT AGATATTAGG AG -            #GAACACCG    660                                                                 - - GTGGCGAAGG CGGTCGTCTG GGCTACAACT GACGCTGATG CACGAAAGCG TG -            #GGGAGCAA    720                                                                 - - ACAGGATTAG ATACCCTGGT AGTCCACGCC GTAAACGATG AGTGCTAGAT AT -            #CGGAAGAT    780                                                                 - - TCTCTTTCGG TTTCGCAGCT AACGCATTAA GCACTCCGCC TGGGGAGTAC GG -            #TCGCAAGA    840                                                                 - - TTAAAACTCA AAGGAATTGA CGGGGGCTCG CACAAGCGGT GGAGCATGCG GT -            #TTAATTCG    900                                                                 - - ATGTTACGCG AAAAACCTTA CCAACCCTTG ACATGGTGGT CGCGGATCGC AG -            #AGATGCTT    960                                                                 - - TTCTTCAGCT CGGCTGGACC ACACACAGGT GTTGCATGGC TGTCGTCAGC TC -            #GTGTCGTG   1020                                                                 - - AGATGTTGGG TTAAGTCCCG CAACGAGCGC AACCCTCATT CTTATTTGCC AG -            #CGGGTAAT   1080                                                                 - - GCCGGGAACT ATAAGAAAAC TGCCGGTGAT AAGCCGGAGG AAGGTGGGGA CG -            #ACGTCAAG   1140                                                                 - - TCATCATGGC CCTTACGGGT TGGGCTACAC GCGTGCTACA ATGGTGTTTA CA -            #GAGGGAAG   1200                                                                 - - CAAGACGGCG ACGTGGAGCA AATCCCTAAA AGACATCTCA GTTCGGATTG TT -            #CTCTGCAA   1260                                                                 - - CTCGAGAGCA TGAAGTTGGA ATCGCTAGTA ATCGCGGATC AGCATGCCGC GG -            #TGAATACG   1320                                                                 - - TTCTCGGGCC TTGTACACAC TGCCCGTCAC GCCATGGGAG TTAGTTTTAC CT -            #GAAGGTGG   1380                                                                 - - TGAGCTAACG CAAGAGGCAG CCAACCACGG TAAAATTAGC GACTGGGGTG AA -            #GTCGTAA    1439                                                                 - -  - - (2) INFORMATION FOR SEQ ID NO:32:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 1432 base - #pairs                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:32:                              - - ACGAACGCTA TCGGTATGCT TAACACATGC AAGTCGAACG AACTAATTTT TG -            #GGGCTTGC     60                                                                 - - TCCAATTAGT TAGTGGCAGA CGGGTGAGTA ACACGTGGGA ATCTACCCAT TA -            #GTACGGAA    120                                                                 - - TAACTTTTAG AAATAAAAGC TAATACCGTA TATTCTCTGC GGAGGAAAGA TT -            #TATCGCTG    180                                                                 - - ATGGATGAGC CCGCGTCAGA TTAGGTAGTT GGTGAGGTAA TGGCTCACCA AG -            #CCGACGAT    240                                                                 - - CTGTAGCTGG TCTGAGAGGA TGATCAGCCA CACTGGGACT GAGACACGGC CC -            #AGACTCCT    300                                                                 - - ACGGGAGGCA GCAGTGGGGA ATATTGGACA ATGGGCGAAA GCCTGATCCA GC -            #AATACCGA    360                                                                 - - GTGAGTGATG AAGGCCTTAG GGTTGTAAAG CTCTTTTAGC AAGGAAGATA AT -            #GACGTTAC    420                                                                 - - TTGCAGAAAA AGCCCCGGCT AACTCCGTGC CAGCAGCCGC GGTAAGACGG AG -            #GGGGCTAG    480                                                                 - - CGTTGTTCGG AATTACTGGG CGTAAAGAGT GCGTAGGCGG TTTAGTAAGT TG -            #GAAGTGAA    540                                                                 - - AGCCCGGGGC TTAACCTCGG AATTGCTTTC AAAACTACTA ATCTAGAGTG TA -            #GTAGGGGA    600                                                                 - - TGATGGAATT CCTAGTGTAG AGGTGAAATT CTTAGATATT AGGAGGAACA CC -            #GGTGGCGA    660                                                                 - - AGGCGGTCAT CTGGGCTACA ACTGACGCTG ATGCACGAAA GCGTGGGGAG CA -            #AACAGGAT    720                                                                 - - TAGATACCCT GGTAGTCCAC GCCGTAAACG ATGAGTGCTA GATATCGGAA GA -            #TTCTCTTT    780                                                                 - - CGGTTTCGCA GCTAACGCAT TAAGCACTCC GCCTGGGGAG TACGGTCGCA AG -            #ATTAAAAC    840                                                                 - - TCAAAGGAAT TGACGGGGGC TCGCACAAGC GGTGGAGCAT GCGGTTTAAT TC -            #GATGTTAC    900                                                                 - - GCGAAAAACC TTACCAACCC TTGACATGGT GGTCGTGGAT CGCAGAGATG CT -            #TTTCTTCA    960                                                                 - - GCTCGGCTGG ACCACACACA GGTGTTGCAT GGCTGTCGTC AGCTCGTGTC GT -            #GAGATGTT   1020                                                                 - - GGGTTAAGTC CCGCAACGAG CGCAACCCTC ATTCTTATTT GCCAGCGGGT AA -            #TGCCGGGA   1080                                                                 - - ACTATAAGAA AACTGCCGGT GATAAGCCGG AGGAAGGTGG GGACGACGTC AA -            #GTCATCAT   1140                                                                 - - GGCCCTTACG GGTTGGGCTA CACGCGTGCT ACAATGGTGT TTACAGAGGG AA -            #GCAAGACG   1200                                                                 - - GCGACGTGGA GCAAATCCCT AAAAGACATC TCAGTTCGGA TTGTTCTCTG CA -            #ACTCGAGA   1260                                                                 - - GCATGAAGTT GGAATCGCTA GTAATCGCGG ATCAGCATGC CGCGGTGAAT AC -            #GTTCTCGG   1320                                                                 - - GCCTTGTACA CACTGCCCGT CACGCCATGG GAGTTAGTTT TACCTGAAGG TG -            #GTGAGCTA   1380                                                                 - - ACGCAAGAGG CAGCCAACCA CGGTAAAATT AGCGACTGGG GTGAAGTCGT AA - #               1432                                                                       - -  - - (2) INFORMATION FOR SEQ ID NO:33:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 1440 base - #pairs                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:33:                              - - CCTGGCTCAG AACGAACGCT ATCGGTATGC TTAACACATG CAAGTCGAAC GG -             #ACTAATTG     60                                                                 - - GGGCTTGCTC TAATTAGTTA GTGGCAGACG GGTGAGTAAC ACGTGGGAAT CT -            #ACCCATCA    120                                                                 - - GTACGGAATA ACTTTTAGAA ATAAAAGCTA ATACCGTATA TTCTCTACGG AG -            #GAAAGATT    180                                                                 - - TATCGCTGAT GGATGAGCCC GCGTCAGATT AGGTAGTTGG TGAGGTAATG GC -            #TCACCAAG    240                                                                 - - CCGACGATCT GTAGCTGGTC TGAGAGGATG ATCAGCCACA CTGGGACTGA GA -            #CACGGCCC    300                                                                 - - AGACTCCTAC GGGAGGCAGC AGTGGGGAAT ATTGGACAAT GGGCGAAAGC CT -            #GATCCAGC    360                                                                 - - AATACCGAGT GAGTGATGAA GGCCTTAGGG TTGTAAAGCT CTTTTAGCAA GG -            #AAGATAAT    420                                                                 - - GACGTTACTT GCAGAAAAAG CCCCGGCTAA CTCCGTGCCA GCAGCCGCGG TA -            #AGACGGAG    480                                                                 - - GGGGCTAGCG TTGTTCGGAA TTACTGGGCG TAAAGAGTGC GTAGGCGGTT TA -            #GTAAGTTG    540                                                                 - - GAAGTGAAAG CCCGGGGCTT AACCTCGGAA TTGCTTTCAA AACTACTAAT CT -            #AGAGTGTA    600                                                                 - - GTAGGGGATG ATGGAATTCC TAGTGTAGAG GTGAAATTCT TAGATATTAG GA -            #GGAACACC    660                                                                 - - GGTGGCGAAG GCGGTCATCT GGGCTACAAC TGACGCTGAT GCACGAAAGC GT -            #GGGGAGCA    720                                                                 - - AACAGGATTA GATACCCTGG TAGTCCACGC CGTAAACGAT GAGTGCTAGA TA -            #TCGGAAGA    780                                                                 - - TTCTCTTTCG GTTTCGCAGC TAACGCATTA AGCACTCCGC CTGGGGAGTA CG -            #GTCGCAAG    840                                                                 - - ATTAAAACTC AAAGGAATTG ACGGGGGCTC GCACAAGCGG TGGAGCATGC GG -            #TTTAATTC    900                                                                 - - GATGTTACGC GAAAAACCTT ACCAACCCTT GACATGGTGG TCGCGGATCG CA -            #GAGATGCT    960                                                                 - - TTTCTTCAGC TCGGCTGGAC CACACACAGG TGTTGCATGG CTGTCGTCAG CT -            #CGTGTCGT   1020                                                                 - - GAGATGTTGG GTTAAGTCCC GCAACGAGCG CAACCCTCAT TCTTATTTGC CA -            #GCGGGTAA   1080                                                                 - - TGCCGGGAAC TATAAGAAAA CTGCCGGTGA TAAGCCGGAG GAAGGTGGGG AT -            #GACGTCAA   1140                                                                 - - GTCATCATGG CCCTTACGGG TTGGGCTACA CGCGTGCTAC AATGGTGTTT AC -            #AGAGGGAA   1200                                                                 - - GCAAGACGGC GACGTGGAGC AAATCCCTAA AAGACATCTC AGTTCGGATT GT -            #TCTCTGCA   1260                                                                 - - ACTCGAGAGC ATGAAGTTGG AATCGCTAGT AATCGCGGAT CAGCATGCCG CG -            #GTGAATAC   1320                                                                 - - GTTCTCGGGC CTTGTACACA CTGCCCGTCA CGCCATGGGA GTTGGTTTTA CC -            #TGAAGGTG   1380                                                                 - - GTGAGCTAAC GCAAGAGGCA GCCAACCACG GTAAAATTAG CGACTGGGGT GA -            #AGTCGTAA   1440                                                                 - -  - - (2) INFORMATION FOR SEQ ID NO:34:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 1436 base - #pairs                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:34:                              - - GCTCAGAACG AACGCTATCG GTATGCTTAA CACATGCAAG TCGAACGGAC TA -            #ATTGGGGC     60                                                                 - - TTGCTCCAAT TAGTTAGTGG CAGACGGGTG AGTAACACGT GGGAATCTAC CC -            #ATCAGTAC    120                                                                 - - GGAATAACTT TTAGAAATAA AAGCTAATAC CGTATATTCT CTACGGAGGA AA -            #GATTTATC    180                                                                 - - GCTGATGGAT GAGCCCGCGT CAGATTAGGT AGTTGGTGAG GTAATGGCTC AC -            #CAAGCCGA    240                                                                 - - CGATCTGTAG CTGGTCTGAG AGGATGATCA GCCACACTGG GACTGAGACA CG -            #GCCCAGAC    300                                                                 - - TCCTACGGGA GGCAGCAGTG GGGAATATTG GACAATGGGC GAAAGCCTGA TC -            #CAGCAATA    360                                                                 - - CCGAGTGAGT GATGAAGGCC TTAGGGTTGT AAAGCTCTTT TAGCAAGGAA GA -            #TAATGACG    420                                                                 - - TTACTTGCAG AAAAAGCCCC GGCTAACTCC GTGCCAGCAG CCGCGGTAAG AC -            #GGAGGGGG    480                                                                 - - CTAGCGTTGT TCGGAATTAC TGGGCGTAAA GAGTGCGTAG GCGGTTTAGT AA -            #GTTGGAAG    540                                                                 - - TGAAAGCCCG GGGCTTAACC TCGGAATTGC TTTCAAAACT ACTAATCTAG AG -            #TGTAGTAG    600                                                                 - - GGGATGATGG AATTCCTAGT GTAGAGGTGA AATTCTTAGA TATTAGGAGG AA -            #CACCGGTG    660                                                                 - - GCGAAGGCGG TCATCTGGGC TACAACTGAC GCTGATGCAC GAAAGCGTGG GG -            #AGCAAACA    720                                                                 - - GGATTAGATA CCCTGGTAGT CCACGCCGTA AACGATGAGT GCTAGATATC GG -            #AAGATTCT    780                                                                 - - CTTTCGGTTT CGCAGCTAAC GCATTAAGCA CTCCGCCTGG GGAGTACGGT CG -            #CAAGATTA    840                                                                 - - AAACTCAAAG GAATTGACGG GGGCTCGCAC AAGCGGTGGA GCATGCGGTT TA -            #ATTCGATG    900                                                                 - - TTACGCGAAA AACCTTACCA ACCCTTGACA TGGTGGTCGC GGATCGCAGA GA -            #TGCTTTTC    960                                                                 - - TTCAGCTCGG CTGGACCACA CACAGGTGTT GCATGGCTGT CGTCAGCTCG TG -            #TCGTGAGA   1020                                                                 - - TGTTGGGTTA AGTCCCGCAA CGAGCGCAAC CCTCATTCTT ATTTGCCAGC GG -            #GTAATGCC   1080                                                                 - - GGGAACTATA AGAAAACTGC CGGTGATAAG CCGGAGGAAG GTGGGGATGA CG -            #TCAAGTCA   1140                                                                 - - TCATGGCCCT TACGGGTTGG GCTACACGCG TGCTACAATG GTGTTTACAG AG -            #GGAAGCAA   1200                                                                 - - GACGGCGACG TGGAGCAAAT CCCTAAAAGA CATCTCAGTT CGGATTGTTC TC -            #TGCAACTC   1260                                                                 - - GAGAGCATGA AGTTGGAATC GCTAGTAATC GCGGATCAGC ATGCCGCGGT GA -            #ATACGTTC   1320                                                                 - - TCGGGCCTTG TACACACTGC CCGTCACGCC ATGGGAGTTG GTTTTACCTG AA -            #GGTGGTGA   1380                                                                 - - GCTAACGCAA GAGGCAGCCA ACCACGGTAA AATTAGCGAC TGGGGTGAAG TC - #GTAA           1436                                                                       - -  - - (2) INFORMATION FOR SEQ ID NO:35:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 1440 base - #pairs                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:35:                              - - CCTGGCTCAG AACGAACGCT ATCGGTATGC TTAACACATG CAAGTCGAAC GG -             #GCTAATTG     60                                                                 - - GGGCTTGCTC CAATTAGTTA GTGGCAGACG GGTGAGTAAC ACGTGGGAAT CT -            #ACCCATCA    120                                                                 - - GTACGGAATA ACTTTTAGAA ATAAAAGCTA ATACCGTATA TTCTCTACGG AG -            #GAAAGATT    180                                                                 - - TATCGCTGAT GGATGAGCCC GCGTCAGATT AGGTAGTTGG TGAGGTAATG GC -            #TCACCAAG    240                                                                 - - CCGACGATCT GTAGCTGGTC TGAGAGGATG ATCAGCCACA CTGGGACTGA GA -            #CACGGCCC    300                                                                 - - AGACTCCTAC GGGAGGCAGC AGTGGGGAAT ATTGGACAAT GGGCGAAAGC CT -            #GATCCAGC    360                                                                 - - AATACCGAGT GAGTGATGAA GGCCTTAGGG TTGTAAAGCT CTTTTAGCAA GG -            #AAGATAAT    420                                                                 - - GACGTTACTT GCAGAAAAAG CCCCGGCTAA CTCCGTGCCA GCAGCCGCGG TA -            #AGACGGAG    480                                                                 - - GGGGCTAGCG TTGTTCGGAA TTACTGGGCG TAAAGAGTGC GTAGGCGGTT TA -            #GTAAGTTG    540                                                                 - - GAAGTGAAAG CCCGGGGCTT AACCTCGGAA TTGCTTTCAA AACTACTAAT CT -            #AGAGTATA    600                                                                 - - GTAGGGGATG ATGGAATTCC TAGTGTAGAG GTGAAATTCT TAGATATTAG GA -            #GGAACACC    660                                                                 - - GGTGGCGAAG GCGGTCATCT GGGCTACAAC TGACGCTGAT GCACGAAAGC GT -            #GGGGAGCA    720                                                                 - - AACAGGATTA GATACCCTGG TAGTCCACGC CGTAAACGAT GAGTGCTAGA TA -            #TCGGAAGA    780                                                                 - - TTCTCTTTCG GTTTCGCAGC TAACGCATTA AGCACTCCGC CTGGGGAGTA CG -            #GTCGCAAG    840                                                                 - - ATTAAAACTC AAAGGAATTG ACGGGGGCTC GCACAAGCGG TGGAGCATGC GG -            #TTTAATTC    900                                                                 - - GATGTTACGC GAAAAACCTT ACCAACCCTT GACATGGTGG TCGCGGATCG CA -            #GAGATGCT    960                                                                 - - TTTCTTCAGC TCGGCTGGAC CACACACAGG TGTTGCATGG CTGTCGTCAG CT -            #CGTGTCGT   1020                                                                 - - GAGATGTTGG GTTAAGTCCC GCAACGAGCG CAACCCTCAT TCTTATTTGC CA -            #GCGGGTAA   1080                                                                 - - TGCCGGGAAC TATAAGAAAA CTGCCGGTGA TAAGCCGGAG GAAGGTGGGG AC -            #GACGTCAA   1140                                                                 - - GTCATCATGG CCCTTACGGG TTGGGCTACA CGCGTGCTAC AATGGTGTTT AC -            #AGAGGGAA   1200                                                                 - - GCAAGACGGC GACGTGGAGC AAATCCCTAA AAGACATCTC AGTTCGGATT GT -            #TCTCTGCA   1260                                                                 - - ACTCGAGAGC ATGAAGTTGG AATCGCTAGT AATCGCGGAT CAGCATGCCG CG -            #GTGAATAC   1320                                                                 - - GTTCTCGGGC CTTGTACACA CTGCCCGTCA CGCCATGGGA GTTGGTTTTA CC -            #TGAAGGTG   1380                                                                 - - GTAAGCTAAC GCAAGAGGCA GCCAACCACG GTAAAATTAG CGACTGGGGT GA -            #AGTCGTAA   1440                                                                 - -  - - (2) INFORMATION FOR SEQ ID NO:36:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 1440 base - #pairs                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:36:                              - - CCTGGCTCAG AACGAACGCT ATCGGTATGC TTAACACATG CAAGTCGAAC GG -            #ACTAATTG     60                                                                 - - GAGCTTGCTC CAATTAGTTA GTGGCAGACG GGTGAGTAAC GCGTGGGAAT CT -            #ACCCATCA    120                                                                 - - GTACGGAATA ACTTTTAGAA ATAAAAGCTA ATACCGTATA TTCTCTACGG AG -            #GAAAGGTT    180                                                                 - - TATCGCTGAT GGATGAGCCC GCGTCAGATT AGGTAGTTGG TGAGGTAATG GC -            #TCACCAAG    240                                                                 - - CCGACGATCT GTAGCTGGTC TGAGAGGATG ATCAGCCACA CTGGGACTGA GA -            #CACGGCCC    300                                                                 - - AGACTCCTAC GGGAGGCAGC AGTGGGGAAT ATTGGACAAT GGGCGAAAGC CT -            #GATCCAGC    360                                                                 - - AATACCGAGT GAGTGATGAA GGCCTTAGGG TTGTAAAGCT CTTTTAGCAG GG -            #AAGATAAT    420                                                                 - - GACGTTACTT GCAGAAAAAG CCCCGGCTAA CTCCGTGCCA GCAGCCGCGG TA -            #AGACGGAG    480                                                                 - - GGGGCTAGCG TTGTTCGGAA TTACTGGGCG TAAAGAGTGC GTAGGCGGTT TA -            #GTAAGTTG    540                                                                 - - GAAGTGAAAG CCCGGGGCTT AACCTCGGAA TTGCTTTCAA AACTACTAAT CT -            #AGAGTGTA    600                                                                 - - GTAGGGGATG ATGGAATTCC TAGTGTAGAG GTGAAATTCT TAGATATTAG GA -            #GGAACACC    660                                                                 - - GGTGGCGAAG GCGGTCATCT GGGCTGCAAC TGACGCTGAT GCACGAAAGC GT -            #GGGGAGCA    720                                                                 - - AACAGGATTA GATACCCTGG TAGTCCACGC CGTAAACGAT GAGTGCTAGA TA -            #TCGGAAGA    780                                                                 - - TTCTCTTTCG GTTTCGCAGC TAACGCATTA AGCACTCCGC CTGGGGAGTA CG -            #GTCGCAAG    840                                                                 - - ATTAAAACTC AAAGGAATTG ACGGGGGCTC GCACAAGCGG TGGAGCATGC GG -            #TTTAATTC    900                                                                 - - GATGTTACGC GAAAAACCTT ACCAACCCTT GACATGGTGG TCGTGAATCG CA -            #GAGATGCT    960                                                                 - - TTTCTTCAGC TCGGCTGGAC CACACACAGG TGTTGCATGG CTGTCGTCAG CT -            #CGTGTCGT   1020                                                                 - - GAGATGTTGG GTTAAGTCCC GCAACGAGCG CAACCCTCAT TCTTATTTGC CA -            #GCGGGTAA   1080                                                                 - - TGCCGGGAAC TATAAGAAAA CTGCCGGTGA TAAGCCGGAG GAAGGTGGGG AC -            #GACGTCAA   1140                                                                 - - GTCATCATGG CCCTTACGGG TTGGGCTACA CGCGTGCTAC AATGGTGTTT AC -            #AGAGGGAA   1200                                                                 - - GCAAGACGGC GACGTGGAGC AAATCCCTAA AAGACATCTC AGTTCGGATT GT -            #TCTCTGCA   1260                                                                 - - ACTCGAGAGC ATGAAGTTGG AATCGCTAGT AATCGCGGAT CAGCATGCCG CG -            #GTGAATAC   1320                                                                 - - GTTCTCGGGC CTTGTACACA CTGCCCGTCA CGCCATGGGA GTTGGTTTTA CC -            #TGAAGGTG   1380                                                                 - - GTGAGCTAAC GCAAGAGGCA GCCAACCACG GTAAAATTAG CGACTGGGGT GA -            #AGTCGTAA   1440                                                                 - -  - - (2) INFORMATION FOR SEQ ID NO:37:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 1440 base - #pairs                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:37:                              - - CCTGGCTCAG AACAAACGCT ATCGGTATGC TTAACACATG CAAGTCGAAC GG -            #ACTAATTG     60                                                                 - - GGGCTTGTTC CAGTTAGTTA GTGGCAGACG GGTGAGTAAC ACGTGGGAAT CT -            #ACCCATCA    120                                                                 - - GTATGGAATA ACTTTTAGAA ATAAAAGCTA ATACCATATA TTCTCTATGG AG -            #GAAAGATT    180                                                                 - - TATCGCTGAT GGATGAGCCC GCGTCAGATT AGGTAGTTGG TGAGGTAACG GC -            #TCACCAAG    240                                                                 - - CCGACGATCT GTAGCTGGTC TGAGAGGATG ATCAGCCACA CTGGGACTGA GA -            #CACGGCCC    300                                                                 - - AGACTCCTAC GGGAGGCAGC AGTGGGGAAT ATTGGACAAT GGGCGAAAGC CT -            #GATCCAGC    360                                                                 - - AATACCGAGT GAGTGATGAA GGCCTTAGGG TTGTAAAGCT CTTTTAGCAA GG -            #AAGATAAT    420                                                                 - - GACGTTACTT GCAGAAAAAG CCCCGGCTAA CTCCGTGCCA GCAGCCGCGG TA -            #AGACGGAG    480                                                                 - - GGGGCTAGCG TTGTTCGGAA TTACTGGGCG TAAAGAGTGC GTAGGCGGTT TA -            #GTAAGTTG    540                                                                 - - GAAGTGAAAG CCCGGGGCTT AACCTCGGAA TTGCTTTCAA AACTACTAAT CT -            #AGAGTGTA    600                                                                 - - GTAGGGGATG ATGGAATTCC TAGTGTAGAG GTGAAATTCT TAGATATTAG GA -            #GGAACACC    660                                                                 - - GGTGGCGAAG GCGATCATCT GGGCTACAAC TGACGCTGAT GCACGAAAGC GT -            #GGGGAGCA    720                                                                 - - AACAGGATTA GATACCCTGG TAGTCCACGC CGTAAACGAT GAGTGCTAGA TA -            #TCGGAAGA    780                                                                 - - TTCTCTTTCG GTTTCGCAGC TAACGCATTA AGCACTCCGC CTGGGGAGTA CG -            #GTCGCAAG    840                                                                 - - ATTAAAACTC AAAGGAATTG ACGGGGGCTC GCACAAGCGG TGGAGCATGC GG -            #TTTAATTC    900                                                                 - - GATGTTACGC GAAAAACCTT ACCAACCCTT GACATGGTGG TCGCGGATCG CA -            #GAGATGCT    960                                                                 - - TTCCTTCAGC TCGGCTGGAC CACACACAGG TGTTGCATGG CTGTCGTCAG CT -            #CGTGTCGT   1020                                                                 - - GAGATGTTGG GTTAAGTCCC GCAACGAGCG CAACCCTCAT TCTTATTTGC CA -            #GCGGGTAA   1080                                                                 - - TGCCAGGAAC TATAAGAAAA CTGCCGGTGA TAAGCCGGAG GAAGGTGGGG AC -            #GACGTCAA   1140                                                                 - - GTCATCATGG CCCTTACGGG TTGGGCTACA CGCGTGCTAC AATGGTGTTT AC -            #AGAGGGAA   1200                                                                 - - GCAAGACGGC GACGTGGAGC AAATCCCTAA AAGACATCTC AGTTCGGATT GT -            #TCTCTGCA   1260                                                                 - - ACTCGAGAGC ATGAAGTTGG AATCGCTAGT AATCGCGGAT CAGCATGCCG CG -            #GTGAATAC   1320                                                                 - - GTTCTCGGGC CTTGTACACA CTGCCCGTCA CGCCATGGGA GTTGGTTTTA CC -            #TGAAGGTG   1380                                                                 - - GTGAGCTAAC GCAAGAGGCA GCCAACCACG GTAAAATTAG CGACTGGGGT GA -            #AGTCGTAA   1440                                                                 - -  - - (2) INFORMATION FOR SEQ ID NO:38:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 1441 base - #pairs                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:38:                              - - CCTGGCTCAG AACGAACGCT ATCGGTATGC TTAACACATG CAAGTCGGAC GG -            #ACTAATTG     60                                                                 - - GGGGTTTACT CTAATTAGTT AGTGGCAGAC GGGTGAGTAA CACGTGGGAA TC -            #TGCCCATC    120                                                                 - - AGTACGGAAT AACTTTTAGA AATAAAAGCT AATACCGTAT ATTCTCTACG GA -            #GGAAAGAT    180                                                                 - - TTATCGCTGA TGGATGAGCC CGCGTCAGAT TAGGTAGTTG GTGAGGTAAC GG -            #CTCACCAA    240                                                                 - - GCCGACGATC TGTAGCTGGT CTGAGAGGAT GATCAGCCAC ACTGGGACTG AG -            #ACACGGCC    300                                                                 - - CAGACTCCTA CGGGAGGCAG CAGTGGGGAA TATTGGACAA TGGGCGAAAG CC -            #TGATCCAG    360                                                                 - - CAATACCGAG TGAGTGATGA AGGCCCTAGG GTTGTAAAGC TCTTTTAGCA AG -            #GAAGATAA    420                                                                 - - TGACGTTACT TGCAGAAAAA GCCCCGGCTA ACTCCGTGCC AGCAGCCGCG GT -            #AAGACGGA    480                                                                 - - GGGGGCTAGC GTTGTTCGGA ATTACTGGGC GTAAAGAGTG CGTAGGCGGT TT -            #AGTAAGTT    540                                                                 - - GGAAGTGAAA GCCCGGGGCT TAACCTCGGA ATTGCTTTCA AAACTACTAA TC -            #TAGAGTGT    600                                                                 - - AGTAGGGGAT GATGGAATTC CTAGTGTAGA GGTGAAATTC TTAGATATTA GG -            #AGGAACAC    660                                                                 - - CGGTGGCGAA GGCGGTCATC TGGGCTACAA CTGACGCTGA TGCACGAAAG CG -            #TGGGGAGC    720                                                                 - - AAACAGGATT AGATACCCTG GTAGTCCACG CCGTAAACGA TGAGTGCTAG AT -            #ATCGGAAG    780                                                                 - - ATTTTCTTTC GGTTTCGCAG CTAACGCATT AAGCACTCCG CCTGGGGAGT AC -            #GGTCGCAA    840                                                                 - - GATTAAAACT CAAAGGAATT GACGGGGGCT CGCACAAGCG GTGGAGCATG CG -            #GTTTAATT    900                                                                 - - CGATGTTACG CGAAGAACCT TACCAACCCT TGACATGGTG GTTGCGGATC GC -            #AGAGATGC    960                                                                 - - TTTCCTTCAG CTCGGCTGGA CCACACACAG GTGTTGCATG GCTGTCGTCA GC -            #TCGTGTCG   1020                                                                 - - TGAGATGTTG GGTTAAGTCC CGCAACGAGC GCAACCCTCA TTCTTATTTG CC -            #AGCGGGTA   1080                                                                 - - ATGCCGGGAA CTATAAGAAA ACTGCCGGTG ATAAGCCGGA GGAAGGTGGG GA -            #CGACGTCA   1140                                                                 - - AGTCATCATG GCCCTTACGG GTTGGGCTAC ACGCGTGCTA CAATGGTGTT TA -            #CAGAGGGA   1200                                                                 - - AGCAAGACGG CGACGTGGAG CAAATCCCTA AAAGACATCT CAGTTCGGAT TG -            #TTCTCTGC   1260                                                                 - - AACTCGAGAG CATGAAGTTG GAATCGCTAG TAATCGCGGA TCAGCATGCC GC -            #GGTGAATA   1320                                                                 - - CGTTCTCGGG CCTTGTACAC ACTGCCCGTC ACGCCATGGG AGTTGGTTTT AC -            #CTGAAGGT   1380                                                                 - - GGTGAGCTAA CGCAAGAGGC AGCCAACCAC GGTAAAATTA GCGACTGGGG TG -            #AAGTCGTA   1440                                                                 - - A                  - #                  - #                  - #                 1441                                                                  - -  - - (2) INFORMATION FOR SEQ ID NO:39:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 1440 base - #pairs                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:39:                              - - CCTGGCTCAG AACGAACGCT ATCGGTATGC TTAACACATG CAAGTCGGAC GG -             #ACTGATTG     60                                                                 - - GGGTTTTCTC CAGTTAGTGA GTGGCGAACG GGTGAGTAAC ACGTGGGAAT CT -            #GCCCATCA    120                                                                 - - GTACGGAATA ACTTTTAGAA ATAAAAGCTA ATACCGTATA TTCTCTACGG AG -            #GAAAGATT    180                                                                 - - TATCGCTGAT GGATGAGCCC GCGTCGGATT AGGTAGTTGG TGAGGTAACG GC -            #TCACCAAG    240                                                                 - - CCGACGATCT GTAGTTGGTC TGAGAGGATG ATCAGCCACA CTGGGACTGA GA -            #CACGGCCC    300                                                                 - - AGACTCCTAC GGGAGGCAGC AGTGGGGAAT ATTGGACAAT GGGCGAAAGC CT -            #GATCCAGC    360                                                                 - - AATACCGAGT GAGTGATGAA GGCCCTAGGG TTGTAAAGCT CTTTTAGCAA GG -            #AAGATAAT    420                                                                 - - GACGTTACTT GCAGAAAAAG CCCCGGCTAA CTCCGTGCCA GCAGCCGCGG TA -            #AGACGGAG    480                                                                 - - GGGGCTAGCG TTGTTCGGAA TTACTGGGCG TAAAGAGTGC GTAGGCGGTT TA -            #GTAAGTTG    540                                                                 - - GAAGTGAAAG CCCGGGGCTT AACCTCGGAA TTGCTTTCAA AACTACTAAT CT -            #AGAGTGTA    600                                                                 - - GTAGGGGATG ATGGAATTCC TAGTGTAGAG GTGAAATTCT TAGATATTAG GA -            #GGAACACC    660                                                                 - - GGTGGCGAAG GCGGTCATCT GGGCTACGAC TGACGCTGAT GCACGAAAGC GT -            #GGGGAGCA    720                                                                 - - AACAGGATTA GATACCCTGG TAGTCCACGC CGTAAACGAT GAGTGCTAGA TA -            #TCGGAAGA    780                                                                 - - GTCTCTTTCG GTTTCGCAGC TAACGCATTA AGCACTCCGC CTGGGGAGTA CG -            #GTCGCAAG    840                                                                 - - ATTAAAACTC AAAGGAATTG ACGGGGGCTC GCACAAGCGG TGGAGCATGC GG -            #TTTAATTC    900                                                                 - - GATGTTACGC GAAAAACCTT ACCAACCTTT GACATGGTGG TTGCGGATCG CA -            #GAGATGCT    960                                                                 - - TTCCTTCAGT TCGGCTGGAC CACACACAGG TGTTGCATGG CTGTCGTCAG CT -            #CGTGTCGT   1020                                                                 - - GAGATGTTGG GTTAAGTCCC GCAACGAGCG CAACCCTCAT TCTTATTTGC CA -            #GCGGGTAA   1080                                                                 - - TGCCGGGAAC TATAAGAAAA CTGCCGGTGA TAAGCCGGAG GAAGGTGGGG AC -            #GACGTCAA   1140                                                                 - - GTCATCATGG CCCTTATGGG TTGGGCTACA CGCGTGCTAC AATGGTGTTT AC -            #AGAGGGAA   1200                                                                 - - GCAAGACGGT AACGTGGAGC AAATCCCTAA AAGACATCTC AGTTCGGATT GT -            #TCTCTGCA   1260                                                                 - - ACTCGAGAGC ATGAAGTTGG AATCGCTAGT AATCGCGGAT CAGCATGCCG CG -            #GTGAATAC   1320                                                                 - - GTTCTCGGGC CTTGTACACA CTGCCCGTCA CGCCATGGGA GTTGGTTTTA CC -            #TGAAGGTG   1380                                                                 - - GTGAGCTAAC GCAAGAGGCA GCCAACCACG GTAGAATTAG CGACTGGGGT GA -            #AGTCGTAA   1440                                                                 - -  - - (2) INFORMATION FOR SEQ ID NO:40:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 1408 base - #pairs                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:40:                              - - CGCTATCGGT ATGCTTAACA CATGCAAGTC GGACGGACTA ATTGGGGCTT GC -            #TCCAATTA     60                                                                 - - GTTAGTGGCA GACGGGTGAG TAACACGTGG GAATCTACCC ATCAGTACGG AA -            #TAACTTTT    120                                                                 - - AGAAATAAAA GCTAATACCG TATATTCTCT ACAGAGGAAA GATTTATCGC TG -            #ATGGATGA    180                                                                 - - GCCCGCGTCA GATTAGGTAG TTGGTGAGGT AACGGCTCAC CAAGCCGACG AT -            #CTGTAGCT    240                                                                 - - GGTCTGAGAG GATGATCAGC CACACTGGGA CTGAGACACG GCCCAGACTC CT -            #ACGGGAGG    300                                                                 - - CAGCAGTGGG GAATATTGGA CAATGGGCGA AAGCCTGATC CAGCAATACC GA -            #GTGAGTGA    360                                                                 - - TGAAGGCCCT AGGGTTGTAA AGCTCTTTTA GCAAGGAAGA TAATGACGTT AC -            #TTGCAGAA    420                                                                 - - AAAGCCCCGG CTAACTCCGT GCCAGCAGCC GCGGTAAGAC GGAGGGGGCT AG -            #CGTTGTTC    480                                                                 - - GGAATTACTG GGCGTAAAGA GTGCGTAGGC GGTTTAGTAA GTTGGAAGTG AA -            #AGCCCGGG    540                                                                 - - GCTTAACCTC GGAATTGCTT TCAAAACTAC TAATCTAGAG TGTAGTAGGG GA -            #TGATGGAA    600                                                                 - - TTCCTAGTGT AGAGGTGAAA TTCTTAGATA TTAGGAGGAA CACCGGTGGC GA -            #AGGCGGTC    660                                                                 - - ATCTGGGCTA CAACTGACGC TGATGCACGA AAGCGTGGGG AGCAAACAGG AT -            #TAGATACC    720                                                                 - - CTGGTAGTCC ACGCCGTAAA CGATGAGTGC TAGATATCGG AAGATTCTCT TT -            #CGGTTTCG    780                                                                 - - CAGCTAACGC ATTAAGCACT CCGCCTGGGG AGTACGGTCG CAAGATTAAA AC -            #TCAAAGGA    840                                                                 - - ATTGACGGGG GCTCGCACAA GCGGTGGAGC ATGCGGTTTA ATTCGATGTT AC -            #GCGAAAAA    900                                                                 - - CCTTACCAAC CCTTGACATG GTGGTCGCGG ATCGCAGAGA TGCTTTCCTT CA -            #GCTCGGCT    960                                                                 - - GGACCACACA CAGGTGTTGC ATGGCTGTCG TCAGCTCGTG TCGTGAGATG TT -            #GGGTTAAG   1020                                                                 - - TCCCGCAACG AGCGCAACCC TCATTCTTAT TTGCCAGCGG GTAATGCCGG GA -            #ACTATAAG   1080                                                                 - - AAAACTGCCG GTGATAAGCC GGAGGAAGGT GGGGACGACG TCAAGTCATC AT -            #GGCCCTTA   1140                                                                 - - CGGGTTGGGC TACACGCGTG CTACAATGGT GTTTACAGAG GGAAGCAAGA CG -            #GCGACGTG   1200                                                                 - - GAGCAAATCC CTAAAAGACA TCTCAGTTCG GATTGTTCTC TGCAACTCGA GA -            #GCATGAAG   1260                                                                 - - TTGGAATCGC TAGTAATCGC GGATCAGCAT GCCGCGGTGA ATACGTTCTC GG -            #GCCTTGTA   1320                                                                 - - CACACTGCCC GTCACGCCAT GGGAGTTGGT TTTACCTGAA GGTGGTGAGC TA -            #ACGCAAGA   1380                                                                 - - GGCAGCCAAC CACGGTAAAA TTAGCGAC         - #                  - #               1408                                                                     - -  - - (2) INFORMATION FOR SEQ ID NO:41:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 1440 base - #pairs                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:41:                              - - CCTGGCTCAG AACGAACGCT ATCGGTATGC TTAACACATG CAAGTCGAAC GG -             #ACTAATTG     60                                                                 - - GGGCTTGCTC CAATTAGTTA GTGGCAGACG GGTGAGTAAC ACGTGGGAAT CT -            #GCCCATCA    120                                                                 - - GTACGGAATA ACTTTTAGAA ATAAAAGCTA ATACCGTATA TTCTCTACGG AG -            #GAAAGATT    180                                                                 - - TATCGCTGAT GGATGAGCCC GCGTCAGATT AGGTAGTTGG TGAGGTAATG GC -            #TCACCAAG    240                                                                 - - CCTACGATCT GTAGCTGGTC TGAGAGGATG ATCAGCCACA CTGGGACTGA GA -            #CACGGCCC    300                                                                 - - AGACTCCTAC GGGAGGCAGC AGTGGGGAAT ATTGGACAAT GGGCGAAAGC CT -            #GATCCAGC    360                                                                 - - AATACCGAGT GAGTGATGAA GGCCCTAGGG TTGTAAAGCT CTTTTAGCAA GG -            #AAGATAAT    420                                                                 - - GACGTTACTT GCAGAAAAAG CCCCGGCTAA CTCCGTGCCA GCAGCCGCGG TA -            #AGACGGAG    480                                                                 - - GGGGCTAGCG TTGTTCGGAA TTACTGGGCG TAAAGAGTGC GTAGGCGGTT TA -            #GTAAGTTG    540                                                                 - - GAAGTGAAAG CCCGGGGCTT AACCTCGGAA TTGCTTTCAA AACTACTAAT CT -            #AGAGTGTA    600                                                                 - - GTAGGGGATG ATGGAATTCC TAGTGTAGAG GTGAAATTCT TAGATATTAG GA -            #GGAACACC    660                                                                 - - GGTGGCGAAG GCGGTCATCT GGGCTACAAC TGACGCTGAT GCACGAAAGC GT -            #GGGGAGCA    720                                                                 - - AACAGGATTA GATACCCTGG TAGTCCACGC CGTAAACGAT GAGTGCTAGA TA -            #TTGGGAGA    780                                                                 - - TTTTCTCTCG GTTTCGCAGC TAACGCATTA AGCACTCCGC CTGGGGAGTA CG -            #GTCGCAAG    840                                                                 - - ATTAAAACTC AAAGGAATTG ACGGGGGCTC GCACAAGCGG TGGAGCATGC GG -            #TTTAATTC    900                                                                 - - GATGTTACGC GAAAAACCTT ACCAACCCTT GACATGGTGG TCGCGGATCG CA -            #GAGATGCT    960                                                                 - - TTCCTTCAGT TCGGCTGGAC CACACACAGG TGTTGCATGG CTGTCGTCAG CT -            #CGTGTCGT   1020                                                                 - - GAGATGTTGG GTTAAGTCCC GCAACGAGCG CAACCCTCAT TCTTATTTGC CA -            #GCGGGTAA   1080                                                                 - - TGCCGGGAAC TATAAGAAAA CTGCCGGTGA TAAGCCGGAG GAAGGTGGGG AC -            #GACGTCAA   1140                                                                 - - GTCATCATGG CCCTTACGGG TTGGGCTACA CGCGTGCTAC AATGGTGTTT AC -            #AGAGGGAA   1200                                                                 - - GCAAGACGGC GACGTGGAGC AAATCCCTAA AAGACATCTC AGTTCGGATT GT -            #TCTCTGCA   1260                                                                 - - ACTCGAGAGC ATGAAGTTGG AATCGCTAGT AATCGCGGAT CAGCATGCCG CG -            #GTGAATAC   1320                                                                 - - GTTCTCGGGC CTTGTACACA CTGCCCGTCA CGCCATGGGA GTTGGTTTTA CC -            #TGAAGGTG   1380                                                                 - - GTGAGCTAAC GCAAGAGGCA GCCAACCACG GTAAAATTAG CGACTGGGGT GA -            #AGTCGTAA   1440                                                                 - -  - - (2) INFORMATION FOR SEQ ID NO:42:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 1439 base - #pairs                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:42:                              - - AGAGTTTGAT CCTGGCTCAG AACGAACGCT ATCGGTATGC TTAACACATG CA -            #AGTCAAAC     60                                                                 - - GGACTAATTG GGGCTTGCTC CAATTAGTTA GTGGCAGACG GGTGAGTAAC AC -            #GTGGGAAT    120                                                                 - - CTCCCCATCA GTACGGAATA ACTTTTAGAA ATAAAAGCTA ATACCGTATA TT -            #CTCTACGG    180                                                                 - - AGGAAAGATT TATCGCTGAT GGATGAGCCC GCGTCAGATT AGGTAGTTGG TG -            #AGGTAATG    240                                                                 - - GCTCACCAAG CCTACGATCT GTAGCTGGTC TGAGAGGATG ATCAGCCACA CT -            #GGGACTGA    300                                                                 - - GACACGGCCC AGACTCCTAC GGGAGGCAGC AGTGGGGAAT ATTGGACAAT GG -            #GCGAAACG    360                                                                 - - NTGATCCAGC AATACCGAGT GAGTGATGAA GGCCTTAGGG TTGTAAAGCT CT -            #TTTAGCAA    420                                                                 - - GGAAGATAAT GACGTTACTT GCAGAAAAAG TCCCGNCTAA CTCCGTGCCA GC -            #AGCCGCGG    480                                                                 - - TAAGACGGAG GGGGCTAGCG TTGTTCGGAA TTACTGGGCG TAAAGAGTGC GT -            #AGGCGGTT    540                                                                 - - TAGTAAGTTG GAAGTGAAAG CCCGGGGCTT AACCTCGGAA TTGCTTTCAA AA -            #CTACTAAT    600                                                                 - - CTAGAGTGTA GTAGGGGATG ATGGAATTCC TAGTGTAGAG GTGAAATTCT TA -            #GATATTAG    660                                                                 - - GAGGAACACC GGTGGCGAAG GCGGTCATCT GGNCTACAAC TGACGCTNAT GC -            #ACGAAAGC    720                                                                 - - GTGGGGAGCA AACAGGATTA GATACCCTGG TAGTCCACGC CGTAAACGAT GA -            #GTGCTAGA    780                                                                 - - TATCGGAGAA TCTCTCTCGG TTTCGCACGT AACGCATTAA GCACTCCGCC TG -            #GGGAGTAC    840                                                                 - - GGTCGCAAGA TTAAAACTCA AAGGAATTGA CGGGGGCTCG CACAAGCGGT GG -            #AGCATGCG    900                                                                 - - GTTTAATTCG ATGTTACGCG AAAAACCTTA CCAACCCTTG ACATGGTGGT CG -            #CGGATCGC    960                                                                 - - AGAGATGCTT TCCTTCAGTT CGGCTGGACC ACACACAGGT GTTGCATGGC TG -            #TCGTCAGC   1020                                                                 - - TCGTGTCGTG AGATGTTGGG TTAAGTCCCG CAACGAGCGC AACCCTCATT CT -            #TATTTGCC   1080                                                                 - - AGCGGGTAAT GCCAGGAACT ATAAGAAAAC TGCCGGTGAT AAGCCGAGAA GG -            #TGGGGACG   1140                                                                 - - ACGTCAAGTC ATCATGGCCC TTACGGGTTG GGCTGCACGC GTGCTACAAT GG -            #TGTTTACA   1200                                                                 - - GAGGGAAGCA AGACGGCGAC GTGGAGCAAA TCCCTAAAAG ACATCTCAGT TC -            #GGATTGCT   1260                                                                 - - CTCTGCAACT CGAGAGCATG AAGTTGGAAT CGCTAGTAAT CGCGGATCAG CA -            #TGCCGCGG   1320                                                                 - - TGAATACGTT CTCGGGCCTT GTACACACTG CCCGTCACGC CATGGGAGTT GG -            #TTTTACCT   1380                                                                 - - GAAGGTGGTG GGCTAACCGC AAGAGGCAGC CAACCACGGT AAAATTAGCG AC -            #TGGGGTG    1439                                                                 - -  - - (2) INFORMATION FOR SEQ ID NO:43:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 1440 base - #pairs                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:43:                              - - CCTGGCTCAG AACGAACGCT ATCGGTATGC TTAACACATG CAAGTCGAAC GG -            #ACTAATTA     60                                                                 - - GGGCTTGCTC TAATTAGTTA GTGGCAGACG GGTGAGTAAC ACGTGGGAAT CT -            #GCCCATCA    120                                                                 - - GTACGGAATA ACTTTTAGAA ATAAAAGCTA ATACCGTATA TTCTCTACAG AG -            #GAAAGATG    180                                                                 - - TATCGCTGAT GGATGAGCCC GCGTCAGATT AGGTAGTTGG TGAGGTAATG GC -            #TCACCAAG    240                                                                 - - CCAACGATCT GTAGCTGGTC TGAGAGGATG ATCAGCCACA CTGGGACTGA GA -            #CACGGCCC    300                                                                 - - AGACTCCTAC GGGAGGCAGC AGTGGGGAAT ATTGGACAAT GGGCGAAAGC CT -            #GATCCAGC    360                                                                 - - AATACCGAGT GAGTGATGAA GGCCTTAGGG TTGTAAAGCT CTTTTAGCAA GG -            #AAGATAAT    420                                                                 - - GACGTTACTT GCAGAAAAAG CCCCGGCTAA CTCCGTGCCA GCAGCCGCGG TA -            #AGACGGAG    480                                                                 - - GGGGCTAGCG TTGTTCGGAA TTACTGGGCG TAAAGAGTGC GTAGGCGGTT TA -            #GTAAGTTG    540                                                                 - - GAAGTGAAAG CCCGGGGCTT AACCTCGGAA TTGCTTTCAA AACTACTAAT CT -            #AGAGTGTA    600                                                                 - - GTAGGGGATG ATGGAATTCC TAGTGTAGAG GTGAAATTCT TAGATATTAG GA -            #GGAACACC    660                                                                 - - GGTGGCGAAG GCGATCATCT AGGCTATAAC TGACGCTGAT GCACGAAAGC GT -            #GGGGAGCA    720                                                                 - - AACAGGATTA GATACCCTGG TAGTCCACGC CGTAAACGAT GAGTGCTAGA TA -            #TCGGGAGA    780                                                                 - - ATATCTCTCG GTTTCGCAGC TAACGCATTA AGCACTCCGC CTGGGGAGTA CG -            #GTCGCAAG    840                                                                 - - ATTAAAACTC AAAGGAATTG ACGGGGGCTC GCACAAGCGG TGGAGCATGC GG -            #TTTAATTC    900                                                                 - - GATGTTACGC GAAAAACCTT ACCAACCCTT GACATGGTGG TCGCGGATTG CA -            #GAGATGCT    960                                                                 - - TTCCTTCAGT TCGGCTGGAC CACACACAGG TGTTGCATGG CTGTCGTCAG CT -            #CGTGTCGT   1020                                                                 - - GAGATGTTGG GTTAAGTCCC GCAACGAGCG CAACCCTCAT TCTTATTTGC CA -            #GCGGATAA   1080                                                                 - - TGCCGGGAAC TATAAGAAAA CTGCCAGTGA TAAGCTGGAG GAAGGTGGGG AC -            #GACGTCAA   1140                                                                 - - GTCATCATGG CCCTTACGGG TTGGGCTACA CGCGTGCTAC AATGGTGTTT AC -            #AGAGGGAA   1200                                                                 - - GCAAAACGGC GACGTGGAGC AAATCCCTAA AAGACATCTC AGTTCGGATT GT -            #TCTCTGCA   1260                                                                 - - ACTCGAGAGC ATGAAGTTGG AATCGCTAGT AATCGCGGAT CAGCATGCCG CG -            #GTGAATAC   1320                                                                 - - GTTCTCGGGC CTTGTACACA CTGCCCGTCA CGCCATGGGA GTTGGTTTTA CC -            #TGAAGGTG   1380                                                                 - - GTGAGCTAAC GCAAGAGGCA GCCAACCACG GTAAAATTAG CGACTGGGGT GA -            #AGTCGTAA   1440                                                                 - -  - - (2) INFORMATION FOR SEQ ID NO:44:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 1508 base - #pairs                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:44:                              - - GACAGAATCA AACTTGAGAG TTTGATCCTG GCTCAGAACG AACGCTATCG GT -            #ATGCTTAA     60                                                                 - - CACATGCAAG TCGAACGGAT TAACTAGAGC TCGCTTTAGT TAATTAGTGG CA -            #GACGGGTG    120                                                                 - - AGTAACACGT GGGAATCTAC CCATCAGTAC GGAATAACTT TTAGAAATAA AA -            #GCTAATAC    180                                                                 - - CGTATATTCT CTACGGAGGA AAGATTTATC GCTGATGGAT GGGCCCGCGT CA -            #GATTAGGT    240                                                                 - - AGTTGGTGAG GTAATGGCTC ACCAAGCCGA CGATCTGTAG CTGGTCTGAG AG -            #GATGATCA    300                                                                 - - GCCACACTGG GACTGAGACA CGGCCCAGAC TCCTACGGGA GGCAGCAGTG GG -            #GAATATTG    360                                                                 - - GACAATGGGC GAAAGCCTGA TCCAGCAATA CCGAGTGAGT GATGAAGGCC TT -            #AGGGTTGT    420                                                                 - - AAAGCTCTTT TAGCAAGGAA GATAATGACG TTACTTGCAG AAAAAGCCCC GG -            #CTAACTCC    480                                                                 - - GTGCCAGCAG CCGCGGTAAG ACGGAGGGGG CTAGCGTTGT TCGGAATTAC TG -            #GGCGTAAA    540                                                                 - - GAGTGCGTAG GCGGTTTAGT AAGTTGGAAG TGAAAGCCCG GGGCTTAACC TC -            #GGAATTGC    600                                                                 - - TTTCAAAACT ACTAATCTAG AGTGTAGTAG GGGATGATGG AATTCCTAGT GT -            #AGAGGTGA    660                                                                 - - AATTCTTAGA TATTAGGAGG AACACCGGTG GCGAAGGCGG TCATCTGGGC TA -            #CAACTGAC    720                                                                 - - GCTGATGCAC GAAAGCGTGG GGAGCAAACA GGATTAGATA CCCTGGTAGT CC -            #ACGCCGTA    780                                                                 - - AACGATGAGT GCTAGATATC GGAGGATTCT CTTTCGGTTT CGCAGCTAAC GC -            #ATTAAGCA    840                                                                 - - CTCCGCCTGG GGAGTACGGT CGCAAGATTA AAACTCAAAG GAATTGACGG GG -            #GCTCGCAC    900                                                                 - - AAGCGGTGGA GCATGCGGTT TAATTCGATG TTACGCGAAA AACCTTACCA AC -            #CCTTGACA    960                                                                 - - TGGTGGTTAC GGATTGCAGA GATGCTTTCC TTCAGTTCGG CTGGGCCACA CA -            #CAGGTGTT   1020                                                                 - - GCATGGCTGT CGTCAGCTCG TGTCGTGAGA TGTTGGGTTA AGTCCCGCAA CG -            #AGCGCAAC   1080                                                                 - - CCTTATTCTT ATTTGCCAGT GGGTAATGCC GGGAACTATA AGAAAACTGC CG -            #GTGATAAG   1140                                                                 - - CCGGAGGAAG GTGGGGACGA CGTCAAGTCA TCATGGCCCT TACGGGTTGG GC -            #TACACGCG   1200                                                                 - - TGCTACAATG GTGTTTACAG AGGGAAGCAA TACGGTGACG TGGAGCAAAT CC -            #CTAAAAGA   1260                                                                 - - CATCTCAGTT CGGATTGTTC TCTGCAACTC GAGAGCATGA AGTTGGAATC GC -            #TAGTAATC   1320                                                                 - - GCGGATCAGC ATGCCGCGGT GAATACGTTC TCGGGCCTTG TACACACTGC CC -            #GTCACGCC   1380                                                                 - - ATGGGAGTTG GTTTTACCTG AAGGTGGTGA GCTAACGCAA GAGGCAGCCA AC -            #CACGGTAA   1440                                                                 - - AATTAGCGAC TGGGGTGAAG TCGTAACAAG GTAGCCGTAG GGGAACCTGC GG -            #CTGGATTA   1500                                                                 - - CCTCCTTA                - #                  - #                       - #        1508                                                                  - -  - - (2) INFORMATION FOR SEQ ID NO:45:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 1458 base - #pairs                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:45:                              - - CAAACTTGAG AGTTTGATCC TGGCTCAGAA CGAACGCTAT CGGTATGCTT AA -            #CACATGCA     60                                                                 - - AGTCGAACGG ATTAATTAGA GCTTGCTCTA GTTAATTAGT GGCAGACGGG TG -            #AGTAACAC    120                                                                 - - GTGGGAATCT ACCCATCAGT ACGGAATAAC TTTTAGAAAT AAAAGCTAAT AC -            #CGTATATT    180                                                                 - - CTCTACGGAG GAAAGATTTA TCGCTGATGG ATGGGCCCGC GTCAGATTAG GT -            #AGTTGGTG    240                                                                 - - TGGTAATGGC TCACCAAGCC GACGATCTGT AGCTGGTCTG AGAGGATGAT CA -            #GCCACACT    300                                                                 - - GGGACTGAGA CACGGCCCAG ACTCCTACGG GAGGCAGCAG TGGGGAATAT TG -            #GACAATGG    360                                                                 - - GCGAAAGCCT GATCCAGCAA TACCGAGTGA GTGATGAAGG CCTTAGGGTT GT -            #AAAGCTCT    420                                                                 - - TTTAGCAAGG AAGATAATGA CGTTACTTGC AGAAAAAGCC CCGGCTAACT CC -            #GTGCCAGC    480                                                                 - - AGCCGCGGTA AGACGGAGGG GGCTAGCGTT GTTCGGAATT ACTGGGCGTA AA -            #GAGTGCGT    540                                                                 - - AGGTGGTTTA GTAAGTTGGA AGTGAAAGCC CGGGGCTTAA CCTCGGAATT GC -            #TTTCAAAA    600                                                                 - - CTACTAATCT AGAGTGTAGT AGGGGATGAT GGAATTCCTA GTGTAGAGGT GA -            #AATTCTTA    660                                                                 - - GATATTAGGA GGAACACCGG TGGCGAAGGC GGTCATCTGG GCTACAACTG AC -            #GCTGATGC    720                                                                 - - ACGAAAGCGT GGGGAGCAAA CAGGATTAGA TACCCTGGTA GTCCACGCCG TA -            #AACGATGA    780                                                                 - - GTGCTAGATA TCGGAGGATT CTCTTTCGGT TTCGCAGCTA ACGCATTAAG CA -            #CTCCGCCT    840                                                                 - - GGGGAGTACG GTCGCAAGAT TAAAACTCAA AGGAATTGAC GGGGGCTCGC AC -            #AAGCGGTG    900                                                                 - - GAGCATGCGG TTTAATTCGA TGTTACGCGA AAAACCTTAC CAACCCTTGA CA -            #TGGTGGTT    960                                                                 - - ATGGATTGCA GAGATGCTTT CCTTCAGTTC GGCTGGGCCA CACACAGGTG TT -            #GCATGGCT   1020                                                                 - - GTCGTCAGCT CGTGTCGTGA GATGTTGGGT TAAGTCCCGC AACGAGCGCA AC -            #CCTTATTC   1080                                                                 - - TTATTTGCCA GCGGGTAATG CCGGGAACTA TAAGAAAACT GCCGGTGATA AG -            #CCGGAGGA   1140                                                                 - - AGGTGGGGAC GACGTCAAGT CATCATGGCC CTTACGGGTT GGGCTACACG CG -            #TGCTACAA   1200                                                                 - - TGGTGTTTAC AGAGGGAAGC AAGACGGTGA CGTGGAGCAA ATCCCTAAAA GA -            #CATCTCAG   1260                                                                 - - TTCGGATTGT TCTCTGCAAC TCGAGAGCAT GAAGTTGGAA TCGCTAGTAA TC -            #GCGGATCA   1320                                                                 - - GCATGCCGCG GTGAATACGT TCTCGGGCCT TGTACACACT GCCCGTCACG CC -            #ATGGGAGT   1380                                                                 - - TGGTTTTACC TGAAGGTGGT GAGCTAACGC AAGAGGCAGC CAACCACGGT AA -            #AATTAGCG   1440                                                                 - - ACTGGGGTGA AGTCGTAA             - #                  - #                      - #1458                                                                  - -  - - (2) INFORMATION FOR SEQ ID NO:46:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 1440 base - #pairs                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:46:                              - - CCTGGCTCAG AACGAACGCT ATCGGTATGC TTAACACATG CAAGTCGAAC GG -             #ATTAATTA     60                                                                 - - GAGCTTGCTC TAGTTAATTA GTGGCAGACG GGTGAGTAAC ACGTGGGAAT CT -            #ACCCATCA    120                                                                 - - GTACGGAATA ACTTTTAGAA ATAAAAGCTA ATACCGTATA TTCTCTACGG AG -            #GAAAGATT    180                                                                 - - TATCGCTGAT GGATGGGCCC GCGTCAGATT AGGTAGTTGG TGTGGTAATG GC -            #TCACCAAG    240                                                                 - - CCGACGATCT GTAGCTGGTC TGAGAGGATG ATCAGCCACA CTGGGACTGA GA -            #CACGGCCC    300                                                                 - - AGACTCCTAC GGGAGGCAGC AGTGGGGAAT ATTGGACAAT GGGCGAAAGC CT -            #GATCCAGC    360                                                                 - - AATACCGAGT GAGTGATGAA GGCCTTAGGG TTGTAAAGCT CTTTTAGCAA GG -            #AAGATAAT    420                                                                 - - GACGTTACTT GCAGAAAAAG CCCCGGCTAA CTCCGTGCCA GCAGCCGCGG TA -            #AGACGGAG    480                                                                 - - GGGGCTAGCG TTGTTCGGAA TTACTGGGCG TAAAGAGTGC GTAGGTGGTT TA -            #GTAAGTTG    540                                                                 - - GAAGTGAAAG CCCGGGGCTT AACCTCGGAA TTGCTTTCAA AACTACTAAT CT -            #AGAGTGTA    600                                                                 - - GTAGGGGATG ATGGAATTCC TAGTGTAGAG GTGAAATTCT TAGATATTAG GA -            #GGAACACC    660                                                                 - - GGTGGCGAAG GCGGTCATCT GGGCTACAAC TGACGCTGAT GCACGAAAGC GT -            #GGGGAGCA    720                                                                 - - AACAGGATTA GATACCCTGG TAGTCCACGC CGTAAACGAT GAGTGCTAGA TA -            #TCGGAGGA    780                                                                 - - TTCTCTTTCG GTTTCGCAGC TAACGCATTA AGCACTCCGC CTGGGGAGTA CG -            #GTCGCAAG    840                                                                 - - ATTAAAACTC AAAGGAATTG ACGGGGGCTC GCACAAGCGG TGGAGCATGC GG -            #TTTAATTC    900                                                                 - - GATGTTACGC GAAAAACCTT ACCAACCCTT GACATGGTGG TTATGGATTG CA -            #GAGATGCT    960                                                                 - - TTCCTTCAGT TCGGCTGGGC CACACACAGG TGTTGCATGG CTGTCGTCAG CT -            #CGTGTCGT   1020                                                                 - - GAGATGTTGG GTTAAGTCCC GCAACGAGCG CAACCCTTAT TCTTATTTGC CA -            #GCGGGTAA   1080                                                                 - - TGCCGGGAAC TATAAGAAAA CTGCCGGTGA TAAGCCGGAG GAAGGTGGGG AC -            #GACGTCAA   1140                                                                 - - GTCATCATGG CCCTTACGGG TTGGGCTACA CGCGTGCTAC AATGGTGTTT AC -            #AGAGGGAA   1200                                                                 - - GCAAGACGGT GACGTGGAGC AAATCCCTAA AAGACATCTC AGTTCGGATT GT -            #TCTCTGCA   1260                                                                 - - ACTCGAGAGC ATGAAGTTGG AATCGCTAGT AATCGCGGAT CAGCATGCCG CG -            #GTGAATAC   1320                                                                 - - GTTCTCGGGC CTTGTACACA CTGCCCGTCA CGCCATGGGA GTTGGTTTTA CC -            #TGAAGGTG   1380                                                                 - - GTGAGCTAAC GCAAGAGGCA GCCAACCACG GTAAAATTAG CGACTGGGGT GA -            #AGTCGTAA   1440                                                                 - -  - - (2) INFORMATION FOR SEQ ID NO:47:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 1569 base - #pairs                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:47:                              - - TTTACGTTTC TTATATTTGT TTTTTTGCAT GAGTCCAAGC CATAAGTAAT TA -            #TGGTTTTG     60                                                                 - - TCAAACTTGA GAGTTTGATC CTGGCTCAGA ACGAACGCTG GCGGCAAGCT TA -            #ACACATGC    120                                                                 - - AAGTCGAACG GACAGTTATT TATAGCTTCG GCTATGAGTA TCTGTTAGTG GC -            #AGACGGGT    180                                                                 - - GAGTAATGCG TAGGAATCTG CCTAGTAGTA TGGAATAGCT ATTAGAAATG AT -            #AGGTAATA    240                                                                 - - CTGTATAATC CCTGCGGGGG AAAGATTTAT CGCTATTAGA TGAGCCTACG TT -            #AGATTAGC    300                                                                 - - TAGTTGGTAA GGTAATGGCT TACCAAGGCA ATGATCTATA GCTGGTCTGA GA -            #GGACGATC    360                                                                 - - AGCCACACTG GAACTGAGAT ACGGTCCAGA CTCCTACGGG AGGCAGCAGT GG -            #GGAATATT    420                                                                 - - GGACAATGGG CGAAAGCCTG ATCCAGCTAT GCCGCGTGAG TGAAGAAGGC CT -            #TCGGGTTG    480                                                                 - - TAAAACTCTT TTAATAGGGA AGATAATGAC GGTACCTATA GAAAAAGTCC CG -            #GCAAACTC    540                                                                 - - CGTGCCAGCA GCCGCGGTAA TACGGAGGGG GCAAGCGTTG TTCGGAATTA TT -            #GGGCGTAA    600                                                                 - - AGGGCACGTA GGTGGACTAG TAAGTTAAAA GTGAAATACC AAAGCTCAAC TT -            #TGGAGCTG    660                                                                 - - CTTTTAATAC TGCTAGACTA GAGGTCGAGA GAGGATAGCG GAATTCCTAG TG -            #TAGAGGTG    720                                                                 - - AAATTCGTAG ATATTAGGAG GAACACCGGT GGCGAAGGCG GCTATCTGGC TC -            #GATACTGA    780                                                                 - - CACTGAGGTG CGAAAGCGTG GGGAGCAAAC AGGATTAGAT ACCCTGGTAG TC -            #CACGCTGT    840                                                                 - - AAACGATGAG TGCTAAATGT GAGGATTTTA TCTTTGTATT GTAGCTAACG CG -            #TTAAGCAC    900                                                                 - - TCCGCCTGGG GACTACGGTC GCAAGACTAA AACTCAAAGG AATTGACGGG GA -            #CCCGCACA    960                                                                 - - AGCGGTGGAG CATGTGGTTT AATTCGATGC AACGCGAAAA ACCTTACCAC TT -            #TTTGACAT   1020                                                                 - - GAAGGTCGTA TCCCTTTTAA CCGAGGGAGT CAGTTCGGCT GGACCTTACA CA -            #GGTGCTGC   1080                                                                 - - ATGGCTGTCG TCAGCTCGTG TCGTGAGATG TTGGGTTAAG TCCCGCAACG AG -            #CGCAACCC   1140                                                                 - - TCATCCTTAG TTACCAACAG GTAATGCTGG GCACTCTAAG GAAACTGCCA GT -            #GATAAACT   1200                                                                 - - GGAGGAAGGT GGGGATGATG TCAAGTCAGC ACGGCCCTTA TAGGGTGGGC TA -            #CACACGTG   1260                                                                 - - CTACAATGGC AACTACAATA GGTTGCGAGA CCGCGAGGTT TAGCTAATCC AA -            #AAAAGTTG   1320                                                                 - - TCTCAGTTCG GATTGTTCTC TGCAACTCGA GAGCATGAAG TCGGAATCGC TA -            #GTAATCGT   1380                                                                 - - GGATCATCAT GCCACGGTGA ATACGTTCTC GGGTCTTGTA CACACTGCCC GT -            #CACGCCAT   1440                                                                 - - GGGAATTGGC TTAACTCGAA GCTGGTGTGC TAACCGTAAG GAAGCAGCCA TT -            #TAAGGTTG   1500                                                                 - - GGTTAGTGAC TAGGGTGAAG TCGTAACAAG GTAGCTGTAG GTGAACCTGC GG -            #CTGGATTA   1560                                                                 - - CCTCCTTTT                - #                  - #                      - #       1569                                                                  - -  - - (2) INFORMATION FOR SEQ ID NO:48:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 1435 base - #pairs                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:48:                              - - CTCAGAACGA ACGCTGGCGG CAAGCCTAAC ACATGCAAGT CGAACGGACA AT -             #TGCTTATA     60                                                                 - - ACCTTTTGGT TATAAATAAT TGTTAGTGGC AGACGGGTGA GTAATGCGTA GG -            #AATCTACC    120                                                                 - - TAGTAGTATG GAATAGCCAT TAGAAATGAT GGGTAATACT GTATAATCCC TG -            #CGGGGGAA    180                                                                 - - AGATTTATCG CTATTAGATG AGCCTACGTT AGATTAGCTA GTTGGTAAGG TA -            #ATGGCTTA    240                                                                 - - CCAAGGCTAT GATCTATAGC TGGTCTGAGA GGACGATCAG CCACACTGGA AC -            #TGAGATAC    300                                                                 - - GGTCCAGACT CCTACGGGAG GCAGCAGTGG GGAATATTGG ACAATGGGCG AA -            #AGCCTGAT    360                                                                 - - CCAGCTATGC CGCGTGAGTG AAGAAGGCCT TCGGGTTGTA AAACTCTTTC AA -            #TAGGGAAG    420                                                                 - - ATAATGACGG TACCTATAGA AGAAGTCCCG GCAAACTCTG TGCCAGCAGC CG -            #CGGTAATA    480                                                                 - - CGGAGGGGGC AAGCGTTGTT CGGAATTATT GGGCGTAAAG GGCACGTAGG TG -            #GACTAGTA    540                                                                 - - AGTTAAAAGT GAAATACCAA GGCTTAACTT TGGAGCGGCT TTTAATACTG CT -            #AGACTAGA    600                                                                 - - GGTCGAAAGA GGATAGCGGA ATTCCTAGTG TAGAGGTGAA ATTCGTAGAT AT -            #TAGGAGGA    660                                                                 - - ACACCAGTGG CGAAAGCGGC TATCTGGTTC GATACTGACA CTGAGGTGCG AA -            #AGCGTGGG    720                                                                 - - GAGCAAACAG GATTAGATAC CCTGGTAGTC CACGCTGTAA ACGATGAGTG CT -            #AAATGTGA    780                                                                 - - GGATTTTATC TTTGTATTGT AGCTAACGCG TTAAGCACTC CGCCTGGGGA CT -            #ACGGTCGC    840                                                                 - - AAGACTAAAA CTCAAAGGAA TTGACGGGGA CCCGCACAAG CGGTGGAGCA TG -            #TGGTTTAA    900                                                                 - - TTCGATGCAA CGCGAAAAAC CTTACCACTT TTTGACATGA AGGTCGTATC CC -            #TCCTAATA    960                                                                 - - GGGGGAGTCA GTTCGGCTGG ACCTTACACA GGTGCTGCAT GGCTGTCGTC AG -            #CTCGTGTC   1020                                                                 - - GTGAGATGTT GGGTTAAGTC CCGCAACGAG CGCAACCCTC ATCCTTAGTT AC -            #CAACAGGT   1080                                                                 - - AATGCTGGGC ACTCTAAGGA AACTGCCAGT GATAAACTGG AGGAAGGTGG GG -            #ATGATGTC   1140                                                                 - - AAGTCAGCAC GGCCCTTATA AGGTGGGCTA CACACGTGCT ACAATGGCAA CT -            #ACAATAGG   1200                                                                 - - TCGCGAGACC GCAAGGTTTA GCTAATCCAT AAAAGTTGTC TCAGTTCGGA TT -            #GTTCTCTG   1260                                                                 - - CAACTCGAGA GCATGAAGTC GGAATCGCTA GTAATCGTGG ATCATCATGC CA -            #CGGTGAAT   1320                                                                 - - ACGTTCTCGG GTCTTGTACA CACTGCCCGT CACGCCATGG GAATTGGCTT AA -            #CTCGAAGC   1380                                                                 - - TGGTGTGCTA ACCGCAAGGA AGCAGCCATT TAAGGTTGGG TTAGTGACTA GG - #GTG            1435                                                                       - -  - - (2) INFORMATION FOR SEQ ID NO:49:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 1494 base - #pairs                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:49:                              - - AGAGTTTGAT CCTGGCTCAG AACGAACGCT GGCGGCAAGC TTAACACATG CA -             #AGTCGAAC     60                                                                 - - GGACCGTATA CGCAGCTTGC TGCGTGTATG GTTAGTGGCA GACGGGTGAG TA -            #ATGCATAG    120                                                                 - - GAATCTACCT AGTAGTATGG GATAGCCACT AGAAATGGTG GGTAATACTG TA -            #TAATCCTG    180                                                                 - - CGGGGGAAAG ATTTATCGCT ATTAGATGAG CCTATGTCAG ATTAGCTAGT TG -            #GTGGGGTA    240                                                                 - - ATGGCCTACC AAGGCGGTGA TCTGTAGCTG GTCTGAGAGG ATGATCAGCC AC -            #ACTGGAAC    300                                                                 - - TGAGACACGG TCCAGACTCC TACGGGAGGC AGCAGTGGGG AATATTGGAC AA -            #TGGGCGCA    360                                                                 - - AGCCTGATCC AGCTATGCCG CGTGAGTGAG GAAGGCCTTA GGGTTGTAAA AC -            #TCTTTCAG    420                                                                 - - TAGGGAAGAT AATGACGGTA CCTACAGAAG AAGTCCCGGC AAACTCCGTG CC -            #AGCAGCCG    480                                                                 - - CGGTAATACG GAGGGGGCAA GCGTTGTTCG GAATTATTGG GCGTAAAGGG CA -            #TGTAGGCG    540                                                                 - - GTTTGGTAAG TTAAAGGTGA AATACCAGGG CTTAACCCTG GGGCTGCTTT TA -            #ATACTGCA    600                                                                 - - GGACTAGAGT CCGGAAGAGG ATAGCGGAAT TCCTAGTGTA GAGGTGAAAT TC -            #GTAGATAT    660                                                                 - - TAGGAGGAAC ACCAGTGGCG AAGGCGGCTG TCTGGTCCGG TACTGACGCT GA -            #GGTGCGAA    720                                                                 - - AGCGTGGGGA GCAAACAGGA TTAGATACCC TGGTAGTCCA CGCTGTAAAC GA -            #TGAGTGCT    780                                                                 - - GAATGTGGGG GCTTTTGCCT CTGTGTTGTA GCTAACGCGT TAAGCACTCC GC -            #CTGGGGAC    840                                                                 - - TACGGTCGCA AGACTAAAAC TCAAAGGAAT TGACGGGGAC NCGCACAAGC GG -            #TGGAGCAT    900                                                                 - - GTGGTTTAAT TCGATGCAAC GCGAAAAACC TTACCACTTC TTGACATGGA GG -            #CTAGATCC    960                                                                 - - TTCTTAACAG AAGGGCGCAG TTCGGCTGGG CCTCGCACAG GTGCTGCATG GC -            #TGTCGTCA   1020                                                                 - - GCTCGTGTCG TGAGATGTTG GGTTAAGTCC CGCAACGAGC GCAACCCTCA TC -            #CTTAGTTA   1080                                                                 - - CCAGCGGGTA ATGCCGGGCA CTTTAAGGAA ACTGCCAGTG ATAAACTGGA GG -            #AAGGTGGG   1140                                                                 - - GATGATGTCA AGTCAGCACG GCCCTTATGG GGTGGGCTAC ACACGTGCTA CA -            #ATGGCGAC   1200                                                                 - - TACAATAGGT TGCAACGTCG CAAGGCTGAG CTAATCCGTA AAAGTCGTCT CA -            #GTTCGGAT   1260                                                                 - - TGTCCTCTGT AACTCGAGGG CATGAAGTCG GAATCGCTAG TAATCGTGGA TC -            #AGCATGCC   1320                                                                 - - ACGGTGAATA CGTTCTCGGG TCTTGTACAC ACTGCCCGTC ACGCCATGGG AA -            #TTGGCTTA   1380                                                                 - - ACTCGAAGCT GGTGCGCCAA CCGTAAGGAG GCAGCCATTT AAGGTTGGGT CG -            #GTGACTGG   1440                                                                 - - GGTGAAGTCG TAACAAGGTA GCTGTAGGTG AACCTGCGGC TGGATCACCT CC - #TT             1494                                                                       - -  - - (2) INFORMATION FOR SEQ ID NO:50:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 1325 base - #pairs                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:50:                              - - GCTCAGAATG AACGCTGGCG GCAGGCCTAA CACATGCAAG TCGAACGGAG TT -             #ATATTGTA     60                                                                 - - GCTTGCTATG GTATAACTTA GTGGCAGACG GGTGAGTAAT GTATAGGAAT CT -            #ACCTAGTA    120                                                                 - - GTACGGAATA ATTGTTGGAA ACGACAACTA ATACCGTATA CGCCCTACGG GG -            #GAAAAATT    180                                                                 - - TATTGCTATT AGATGAGCCT ATATTAGATT AGCTAGTTGG TGGGGTAATA GC -            #CTACCAAG    240                                                                 - - GTAATGATCT ATAGCTGATC TGAGAGGATG ATCAGCCACA CTGGAACTGA GA -            #TACGGTCC    300                                                                 - - AGACTCCTAC GGGAGGCAGC AGTGGGGAAT ATTGGACAAT GGGCGAAAGC CT -            #GATCCAGC    360                                                                 - - CATGCCGCAT GAGTGAAGAA GGCCTTTGGG TTGTAAAGCT CTTTTAGTGA GG -            #AAGATAAT    420                                                                 - - GACGGTACTC ACAGAAGAAG TCCTGGCTAA CTCCGTGCCA GCAGCCGCGG TA -            #ATACGGAG    480                                                                 - - AGGGCTAGCG TTATTCGGAA TTATTGGGCG TAAAGGGCGC GTAGGCTGGT TA -            #ATAAGTTA    540                                                                 - - AAAGTGAAAT CCCGAGGCTT AACCTTGGAA TTGCTTTTAA AACTATTAAT CT -            #AGAGATTG    600                                                                 - - AAAGAGGATA GAGGAATTCC TGATGTAGAG GTAAAATTCG TAAATATTAG GA -            #GGAACACC    660                                                                 - - AGTGGCGAAG GCGTCTATCT GGTTCAAATC TGACGCTGAA GCGCGAAGGC GT -            #GGGGAGCA    720                                                                 - - AACAGGATTA GATACCCTGG TAGTCCACGC TGTAAACGAT GAATGTTAAA TA -            #TGGGGAGT    780                                                                 - - TTACTTTCTG TATTACAGCT AACGCGTTAA ACATTCCGCC TGGGGACTAC GG -            #TCGCAAGA    840                                                                 - - TTAAAACTCA AAGGAATTGA CGGGGACCCG CACAAGCGGT GGAGCATGTG GT -            #TTAATTCG    900                                                                 - - ATGCAACGCG AAAAACCTTA CCACTTCTTG ACATGAAAAT CATACCTATT CG -            #AAGGGATA    960                                                                 - - GGGTCGGTTC GGCCGGATTT TACACAAGTG TTGCATGGCT GTCGTCAGCT CG -            #TGTCGTGA   1020                                                                 - - GATGTTGGGT TAAGTCCCGC AACGAGCGCA ACCCTCATCC TTAGTTGCCA TC -            #AGGTAATG   1080                                                                 - - CTGAGTACTT TAAGGAAACT GCCAGTGATA AGCTGGAGGA AGGTGGGGAT GA -            #TGTCAAGT   1140                                                                 - - CATCATGGCC TTTATGGAGT GGGCTACACA CGTGCTACAA TGGTGTCTAC AA -            #TGGGCTGC   1200                                                                 - - AAGGTGCGCA AGCCTAAGCT AATCCCTAAA AGACATCTCA GTTCGGATTG TA -            #CTCTGCAA   1260                                                                 - - CTCGAGTACA TGAAGTTGGA ATCGCTAGTA ATCGTGGATC AGCATGCCAC GG -            #TGAATACG   1320                                                                 - - TTCTC                 - #                  - #                  -      #          1325                                                                  - -  - - (2) INFORMATION FOR SEQ ID NO:51:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 1498 base - #pairs                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:51:                              - - CTGATTTGAG AGTTTGATCC TGGCTCAGAA CGAACGCTAG CGGTAGGCTT AA -            #CACATGCA     60                                                                 - - AGTCGAACGG AATCAGGGCT GCTTGCAGCC TTGGTCCCGT GGCAGACGGG TG -            #CGTAACGC    120                                                                 - - GTGGGAACTT GCCTGGTAGT AGGGAATAAC CAGTGGAAAC ATTGGGCAAC AC -            #CCTATACG    180                                                                 - - CCCTGAGGGG GAAAATTTAT TGCTATCAGA TAGGCCCGCG TTAGATTAGC TA -            #GTTGGTGG    240                                                                 - - GGTAATGGCC TACCAAGGCG ACGATCTATA GCTGGTCTGA GAGGATGATC AG -            #CCACACTG    300                                                                 - - GAACTGAGAC ACGGTCCAGA CTCCTACGGG AGGCAGCAGT GAGGAATATT GG -            #ACAATGGG    360                                                                 - - CGAAAGCCTG ATCCAGCCAT ACCGCATGAG TGATGAAGGC CCTTGGGTTG TA -            #AAGCTCTT    420                                                                 - - TTAGTGGGGA AGATAATGAC GGTACCCACA GAAGAAGTCC CGGCTAACTC CG -            #TGCCAGCA    480                                                                 - - GCCGCGGTAA TACGGAGGGG GCTAGCGTTG TTCGGAATTA CTGGGCGTAA AG -            #GGTGCGTA    540                                                                 - - GGCGGTCCCG TAAGTTAGGT GTGAAATCCT TGGGCTTAAC CCAAGAACTG CA -            #TTTAAAAC    600                                                                 - - TGTGGGACTC GAACGTGAGA GAGGGCAATG GAATTTTTGG TGTAGGGGTG AA -            #ATCCGTAG    660                                                                 - - ATATCAAGAG GAACGTCAGG GGCGAAAGCG ATTGCCTGGA TCACAGTTGA CG -            #CTGAGGCA    720                                                                 - - CGAAAGCGTG GGGAGCAAAC AGGATTAGAT ACCCTGGTAG TCCACGCTGT AA -            #ACGATGAG    780                                                                 - - TGTTAAAAGT GGGTTATTTT ATCTGCTTTG TAGCTAACGC GTTAAACACT CC -            #GCCTGGGG    840                                                                 - - ACTACGGTCG CAAGACTAAA ACTCAAAGGA ATTGACGGGG ACTCGCACAA GC -            #GGTGGAGT    900                                                                 - - ATGTGGTTTA ATTCGATGCA ACGCGAAAAA CCTTACCATA CCTTGACATG TG -            #GATTGTAT    960                                                                 - - CCCTCTGAAG GGAGGGAGTC AGTTCGGCTG GATCCAACAC AGGTGTTGCA TG -            #GCTGTCGT   1020                                                                 - - CAGCTCGTGT CGTGAGATGT TGGGTTAAGT CCCGCAACGA GCGCAACCCT CA -            #TCCTTAGT   1080                                                                 - - TGCCAGCGGT TCGGCCGGGA ACTTTAAGGA AACTGCCAGT GACAAGCTGG AG -            #GAAGGTGG   1140                                                                 - - GGACGACGTC AAGTCATCAT GGCCCTTATG GTATGGGCTA CACACGTACT AC -            #AATGGCAA   1200                                                                 - - CTACAATGAG CTAGCTACAC CGTAAGGTGA CGCCAATCTC TTAAAGGTTG TC -            #TCAGTACG   1260                                                                 - - GATTGCCTTC TGCAACTCGA AGGCATGAAG TTGGAATCGC TAGTAATCGC AG -            #ATCAGCAT   1320                                                                 - - GCTGCGGTGA ATACGTTCTC GGGTCTTGTA CACACTGCCC GTCAGGCCAT GG -            #GAGTTCAT   1380                                                                 - - CTTACTCGAA GCTAGTGAGC TGACCGCAAG GAGGCAGCTA TCTACGGTGG GG -            #TGGGTGAC   1440                                                                 - - TGGGGTTAAG TCGTAACAAG GTAGCCGTAG GTGAACCTGC GGCTGGATTA CC -            #TCCTTT     1498                                                                 - -  - - (2) INFORMATION FOR SEQ ID NO:52:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 1415 base - #pairs                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:52:                              - - CTCAGAACGA ACGCTGGCGG CAGGCTTAAC ACATGCAAGT CGAGCGCACT CT -            #TTTAGAGT     60                                                                 - - GAGCGGCAAA CGGGTGAGTA ACGCGTGGGA ATCTACCCAT CTCTACGGAA TA -            #ACACAGAG    120                                                                 - - AAATTTGTGC TAATACCGTA TACGTCCCTC TGGGAGAAAG ATTTATCGGA GG -            #TGGATGAG    180                                                                 - - CCCGCGTTGG ATTAGCTAGT TGGTGAGGTA AGGGCTCACC AAGGCGACGA TC -            #CATAGCTG    240                                                                 - - GTCTGAGAGG ATGATCAGCC ACACTGGGAC TGAGACACGG CCCAGACTCC TA -            #CGGGAGGC    300                                                                 - - AGCAGTGGGG AATATTGGAC AATGGGGGCA ACCCTGATCC AGCCATGCCG CG -            #TGAGTGAT    360                                                                 - - GAAGGCCCTA GGGTTGTAAA GCTCTTTCAC CGGTGAAGAT AATGACGTTA AC -            #CGGAGAAG    420                                                                 - - AAGCCCCGGC TAACTTCGTG CCAGCAGCCG CGGTAATACG AAGGGGGCTA GC -            #GTTGTTCG    480                                                                 - - GATTTACTGG GCGTAAAGCG CATGTAGGCG GATATTTAAG TCAGAGGTGA AA -            #TCCCAGGG    540                                                                 - - CTCAACCCTG GAACTGCCTT TGATACTGGA TGTCTCGAGT GTGGAAGAGG TG -            #AGTGGAAT    600                                                                 - - TCCGAGTGTA GAGGTAAAAT TCGTAGATAT TCGGAGGAAC ACCAGTGGCG AA -            #GGCGGCTC    660                                                                 - - ACTGGTCCAT TACTGACGCT GAGGTGCGAA AGCGTGGGGA GCAAACAGGA TT -            #AGATACCC    720                                                                 - - TGGTAGTCCA CGCCGTAAAC GATGAATGTT AGCCGTCGGG TGGTTTACTA CT -            #CGGTGGCG    780                                                                 - - CACGTAACGC GTTAAACATT CCGCCTGGGG AGTACGGTCG CAAGATTAAA AC -            #TCAAAGGA    840                                                                 - - ATTGACGGGG GCCCGCACAA GCGTGGAGCA TGTGGTTTAA TTCGAAGCAA CG -            #CGCAGAAC    900                                                                 - - CTTACCAGCC CTTGACATCC CGATCGCGGA AGGTGGAGAC ACCCTCCTTC AG -            #TTAGGCTG    960                                                                 - - GATCGGTGAC AGGTGCTGCA TGGCTGTCGT CAGCTCGTGT CGTGAGATGT TG -            #GGTTAAGT   1020                                                                 - - CCCGCAACGA GCGCAACCCT CGCCCTTAGT TGCCATCATT AAGTTGGGCA CT -            #CTAGGGGG   1080                                                                 - - ACTGCCGGTG ATAAGCCGAG AGGAAGGTGG GGATGACGTC AAGTCCTCAT GG -            #CCCTTACG   1140                                                                 - - GGCTGGGCTA CACACGTGCT ACAATGGTGG TGACAGTGGG CAGCGAGACC GC -            #GAGGTCGA   1200                                                                 - - GCTAATCTCC AAAAGCCATC TCAGTTCGGA TTGCACTCTG CAACTCGAGT GC -            #ATGAAGTT   1260                                                                 - - GGAATCGCTA GTAATCGTGG ATCAGCATGC CACGGTGAAT ACGTTCCCGG GC -            #CTTGTACA   1320                                                                 - - CACCGCCCGT CACACCATGG GAGTTGGTTT TACCCGAAGG TGCTGTGCTA AC -            #CGCAAGGA   1380                                                                 - - GGCAGGCAAC CACGGTAGGG TCAGCGACTG GGGTG       - #                       - #     1415                                                                     - -  - - (2) INFORMATION FOR SEQ ID NO:53:                                    - -      (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 1484 base - #pairs                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                 - -     (ii) MOLECULE TYPE: DNA (genomic)                                     - -     (xi) SEQUENCE DESCRIPTION: SEQ ID NO:53:                              - - NNATTGAAGA GTTTGATTCT GGCTCAGATT GAACGCTAGC GGCATGCTTA AC -            #ACATGCAA     60                                                                 - - GTCGAACGGC AGCGCAGGGA GNCTTNCTCC TGGCGGCGAG AGTGGCGGAC GG -            #GTGAGTAA    120                                                                 - - TGCGTAGGAA TCTACCTTGT AGTGGGGGAT AACCTGGGGA AACTCGGGCT AA -            #TACCGTAT    180                                                                 - - AATCTCTTTG GAGCAAAGCG GGGGATCTTC GGACCTCGTG CTATAAGATG AG -            #CCTACGTC    240                                                                 - - GGATTAGCTT GTTGGTGGGG TAATGGCCTA CCAAGGCGAC GATCCGTAGC TG -            #GTCTGAGA    300                                                                 - - GGACGATCAG CCACACTGGG ACTGAGACNC GGCCCAGACT CCTACGGGAG GC -            #AGCAGTGG    360                                                                 - - GGAATATTGG ACAATGGGGG AAACCCTGAT CCAGCAATGC CGCGTGTGTG AA -            #GAAGGCCT    420                                                                 - - TCGGGTTGTA AAGCACTTTC GGTGGGGAAG AAATTCTCAA GGGTAATATC CT -            #NGGGCGTT    480                                                                 - - GACGTTACCC ACAGAAGAAG CACTGGCTAA CTCTGTGCCA GCAGCCGCGG TA -            #ATACAGAG    540                                                                 - - AGTGCAAGCG TTAATCGGAA TCACTGGGCG TAAAGCGCGC GTAGGTGGAT AT -            #TTAAGTCG    600                                                                 - - GATGTGAAAG CCCTGGGCTN NNCCTGGGAA TTGCACCCGA TACTGGGTAT CT -            #TGAGTATG    660                                                                 - - GTAGAGGGAA NTGGAATTTC CGGTGTAGCG GTGAAATGCG TAGATATCGG AA -            #AGAACACC    720                                                                 - - AGTGGCGAAG GCGACTTCCT GGACCAATAC TGACACTGAG GCGCGAAAGC GT -            #GGGGAGCA    780                                                                 - - AACAGGATTA GAGACCCTGG TAGTCCACGC NGTCAACGAT GAGAACTAGC TG -            #TTGGGAAG    840                                                                 - - TTCCCTTCTT AGTAGCGAAG CTAACGCGTT AAGTTCTCCG CCTGGGGAGT AC -            #GGCCGCAA    900                                                                 - - GGTTAAAACT CAAAGAAATT GACGGGGGCN CGCACAAGCG GTGGAGCATG TG -            #GTTTAATT    960                                                                 - - CGATGCAACG CGAAAAACCT TACCTACCCT TGACATCCTC GGAACTTGTC AG -            #AGATGATT   1020                                                                 - - TGGTGCCTTC GGGAACCGAG TGACAGGTGC TGCATGGCTG TCGTCAGCTC GT -            #GTCGTGAG   1080                                                                 - - ATGTTGGGTT AAGTCCCGTA ACGAGCGCAA CCCTCGTCCT TAGTTGCCAG CG -            #AGTCAAGT   1140                                                                 - - CGGGAACTCT AAGGAGACTG CCGGTGATAA ACCGGAGGAA GGTGGGGATG AT -            #GTCAAGTC   1200                                                                 - - ATCATGGCCC TTACGGGTAG GGCTACACAC GTGCTACAAT GGGCAGTACA AA -            #GGGTTGCC   1260                                                                 - - AAGCCGCGAG GTGGAGCTAA TCCCAGAAAA CTGCTCGTAG TCCGGATTGG AG -            #TCTGCAAC   1320                                                                 - - TCGACTCCAT GAAGTTGGAA TCGCTAGTAA TCGCGAATCA GCATGTCGCG GT -            #GAATACGT   1380                                                                 - - TCTCGGGCCT TGTACACACC GCCCGTCACA CCATGGGAGT GAATTGTACC AG -            #AAGCGGGT   1440                                                                 - - AGGCTAACCT TCGGGAGGCC GCTCACCACG GTATGATCCA NGAC   - #                     148 - #4                                                                  __________________________________________________________________________

We claim:
 1. A single-stranded nucleotide fragment of up to 35nucleotide units, said fragment being capable of hybridizing to rDNA orrRNA of at least one bacterium of the genus Rickettsia and nothybridizing to non-Rickettsia rDNA or rRNA, wherein said fragmentcomprises an oligonucleotide selected from the group consisting of:a)polynucleotide fragments of a range of nucleotides selected from thegroup of ranges consisting of bases 130 to 170, 181 to 201, 241 to 272,284 to 298, 299 to 315, 334 to 357, 460 to 481, 504 to 536, 550 to570,561 to 585, 661 to 684, 710 to 739, 940 to 960, 1035 to 1055, 1078to 1107, 1199 to 1213, 1330 to 1350, 1361 to 1387, 1429 to 1463, 1501 to1520 and 1555 to 1576 as numbered in Table 1 of a nucleic acid oligomerselected from the group consisting of SEQ ID NOS: 23-45, and theircomplementary sequences, analogues of said SEQ ID NOS, and analogues ofsaid complementary sequences, said oligonucleotide having at least eightconsecutive nucleotides of said polynucleotide fragments; b)polynucleotide fragments of a range of nucleotides selected from thegroup of ranges consisting of bases 130 to 170, 181 to 201, 241 to 272,284 to 298, 299 to 315, 334 to 357, 460 to 481, 504 to 536, 550 to 570,561 to 585, 661 to 684, 710 to 739, 940 to 960, 1035 to 1055, 1078 to1107, 1199 to 1213, 1330 to 1350, 1361 to 1387, 1429 to 1463, and 1555to 1576 as numbered in Table 1 of a nucleic acid oligomer as set forthin SEQ ID NO: 46, its complementary sequences, analogues of said SEQ IDNO, and analogues of said complementary sequence, said oligonucleotidehaving at least eight consecutive nucleotides of said polynucleotidefragments; and c) polynucleotide fragments of a range of nucleotides ofa range of bases 903 to 929 as numbered in Table 1 of a nucleic acidoligomer selected from the group consisting of SEQ ID NOS: 28 39, 41-43and 46, and their complementary sequences, analogues of said SEQ ID NOS,and analogues of said complementary sequences, said oligonucleotidehaving at least ten consecutive nucleotides of said polynucleotidefragments.
 2. A single-stranded nucleotide fragment according to claim1, wherein said oligonucleotide comprises at least ten consecutivenucleotides of said polynucleotide.
 3. A single-stranded nucleotidefragment according to claim 1, wherein said non-Rickettsia compriseCowdria ruminantium, Ehrlichia chaffeensis, Anaplasma marginale,Wolbachia pipientis, Ehrlichia risticii, Rochalimea quintana andCoxiella burnatti.
 4. A single-stranded nucleotide fragment according toclaim 1, consisting of said oligonucleotide.
 5. A single-strandednucleotide fragment of up to 35 nucleotides capable of hybridizing torDNA or rRNA of at least one bacterium of the genus Rickettsia and nothybridizing to non-Rickettsia rDNA or rRNA, comprising anoligonucleotide of at least eight consecutive nucleotides of apolynucleotide selected from the group consisting of SEQ ID NOS: 1-20and 22, complementary sequences of SEQ ID NOS: 1-20 and 22, analogues ofsaid SEQ ID NOS: 1-20 and 22 and analogues of said complementarysequences of SEQ ID NOS: 1-20 and
 22. 6. A single-stranded nucleotidefragment of RNA, comprising a transcription product of anoligonucleotide fragment of DNA according to claim
 1. 7. Asingle-stranded nucleotide fragment of DNA, wherein said fragment isobtained by reverse transcription of an oligonucleotide fragment of RNAaccording to claim
 5. 8. A single-stranded nucleotide fragment ofgenomic DNA, wherein a transcription product of said fragment is anoligonucleotide fragment of RNA according to claim
 5. 9. A probe foridentification of bacteria of the genus Rickettsia comprising a probesequence of eight to thirty-five nucleotide units of a polynucleotidefragment as defined in claim
 1. 10. A probe for identification ofbacteria of the species R. tsutsugamushi, comprising a probe sequence ofeight to thirty-five nucleotide units of a polynucleotide fragment asdefined in claim
 1. 11. A probe according to claim 8, wherein saidfragment is selected from the group of polynucleotide fragments of arange of nucleotides consisting of bases 181 to 201, 284 to 298, 561 to585, 940 to 960, 1199 to 1213 and 1429 to 1463 as numbered in Table 1and their complementary sequences.
 12. A probe according to claim 9,wherein said polynucleotide fragment is selected from the groupconsisting of SEQ ID NOS: 1, 3, 5, 6, 7, 8, 9, 11, 12, 13, 15, 16, 18,19 and 22 and their complementary sequences.
 13. A therapy probe fortreatment of infection caused by the genus Rickettsia or by a determinedspecies of rickettsias, comprising a nucleotide fragment according toclaim
 1. 14. A primer for specific reverse transcription of a 16Sribosomal RNA sequence of Rickettsia, said sequence belonging to aregion uniquely conserved among rickettsias, comprising a nucleotidefragment according to claim
 1. 15. A primer for specific enzymaticamplification of a DNA or RNA sequence complementary or homologous to asequence of a 16S ribosomal RNA of Rickettsia, comprising a nucleotidefragment according to claim
 1. 16. A reagent for detecting oridentifying at least one species of Rickettsia in a biological sample,comprising at least one single-stranded nucleotide fragment according toclaim
 1. 17. A reagent according to claim 16, wherein said nucleotidefragment is attached to a solid support.
 18. A reagent according toclaim 16, wherein said nucleotide fragment is labelled.
 19. A reagentaccording to claim 16, wherein said at least one probe comprises atleast one primer selected from the group consisting of a primer forspecific reverse transcription of a 16S ribosomal RNA sequence ofRickettsia, said RNA sequence belonging to a region uniquely conservedamong rickettsias, and a primer for specific enzymatic amplification ofDNA or RNA complementary or homologous to a sequence of a 16S ribosomalRNA of Rickettsia.
 20. A process for detection or identification ofRickettsia in a biological sample, comprising:a. bringing said sampleinto contact with at least one single-stranded nucleotide fragment asdefined in claim 1, under predetermined conditions which allow thefragment to hybridize to rDNA or rRNA of a bacterium of the genusRickettsia, if present, to form a hybrid; and b. detecting said hybrid.21. A process for detection or identification of at least one species ofthe genus Rickettsia in a biological sample, comprising:a. extracting16S ribosomal RNA from bacteria contained in the said sample to form ananalyte; b. contacting said analyte with at least one probe as definedin claim 9, and c. detecting possible hybridization of the said probe.22. A process for detection or identification of at least one species ofthe genus Rickettsia in a biological sample, comprising:a. extractingand denaturing genomic DNA from bacteria contained in the said sample toform a denatured analyte; b. contacting said denatured analyte with atleast one probe as defined in claim 9; and c. detecting possiblehybridization of said probe to said denatured analyte.
 23. A process fordetection or identification of a species of the genus Rickettsia in abiological sample, comprising:a. obtaining DNA by reverse transcriptionof 16S ribosomal RNA of bacteria contained in said sample; b. contactingsaid DNA with at least one probe as defined in claim 9; and c. detectingpossible hybridization of said probe to said DNA.
 24. A processaccording to claim 21, further comprising amplifying said RNA or reversetranscripts thereof contained in said analyte in the presence of anenzymatic amplification system having at least one primer selected fromthe group consisting of a primer for a specific reverse transcription ofa 16S ribosomal RNA sequence of genus Rickettsia, said sequencebelonging to a region uniquely conserved among Rickettsia, and a primerfor specific enzymatic amplification of a DNA or RNA sequencecomplementary or homologous to a sequence of a 16S ribosomal RNA ofRickettsia to form said analyte, then contacting the amplified nucleicacid to said probe.
 25. A single-stranded nucleotide fragment accordingto claim 1, capable of distinguishing non-Rickettsia from Rickettsiaselected from the group consisting of R. tsutsugamushi, R. canada, R.conorii, R. akari, R. mooseri, R. australis, R. rhipicephali, R,montana, R. bellii, R. japonica, R. parkeri, R. helvetica, R. sibirica.R. massiliae, R. slovaca and R. africae.
 26. A single-strandednucleotide fragment of up to 35 nucleotide units, said fragment beingcapable of hybridizing to rDNA or rRNA of at least one bacterium of thegenus Rickettsia and not hybridizing to non-Rickettsia rDNA or rRNA,wherein said fragment comprises an oligonucleotide of at least tenconsecutive nucleotides of a polynucleotide selected from the groupconsisting of polynucleotide fragments of a range of nucleotidesselected from the group of ranges consisting of:bases 130 to 170, 181 to201, 241 to 272, 284 to 298, 299 to 315, 334 to 357, 460 to 481, 504 to536, 550 to 570, 561 to 585, 661 to 684, 710 to 739, 903 to 929, 940 to960, 1035 to 1055, 1078 to 1107, 1199 to 1213, 1330 to 1350, 1361 to1387, 1429 to 1463, 1501 to 1520 and 1555 to 1576 as numbered in Table 1of a nucleic acid oligomer selected from the group consisting of SEQ IDNOS: 28, 39,41,42 and 43, and their complementary sequences; bases 130to 170, 181 to 201, 241 to 272, 284 to 298, 299 to 315, 334 to 357, 460to 491, 504 to 536, 550 to 570, 561 to 585, 661 to 684, 710 to 739, 940to 960, 1035 to 1055, 1078 to 1107, 1199 to 1213, 1330 to 1350, 1361 to1387, 1429 to 1463, 1501 to 1520 and 1555 to 1576 as numbered in Table 1of a nucleic acid oligomer selected from the group consisting of SEQ IDNOS: 23-27, 29-38, 40, 44, and 45, and their complementary sequences;and bases 130 to 170, 181 to 201, 241 to 272, 284 to 298, 299 to 315,334 to 357, 460 to 491, 504 to 536, 550 to 570, 561 to 585, 661 to 684,710 to 739, 903 to 929, 940 to 960, 1035 to 1055, 1078 to 1107, 1199 to1213, 1330 to 1350, 1361 to 1387, 1429 to 1463 and 1555 to 1576 asnumbered in Table 1 of a nucleic acid oligomer SEQ ID NO: 46, and itscomplementary sequence.
 27. A single-stranded nucleotide fragment of upto 35 nucleotide units capable of hybridizing to rDNA or rRNA of atleast one bacterium of the genus Rickettsia and not hybridizing tonon-Rickettsia rDNA or rRNA, comprising an oligonucleotide of at least10 consecutive nucleotides of a polynucleotide selected from the groupconsisting of SEQ ID NOS: 1-20 and 22, and complementary sequencesthereof.